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Find Clinical Drug Pipeline Developments & Deals by Codiak BioSciences
exoVACC is modular vaccine system that utilizes the unique properties of exosomes to deliver antigens and adjuvants simultaneously and selectively to the same antigen presenting cells (APCs), driving an integrated innate, cellular and/or antibody-mediated immune response.
Codiak’s exoASO-STAT6 is an engineered exosome investigational therapeutic candidate designed to selectively deliver antisense oligonucleotides (ASOs) to disrupt STAT6 signaling in tumor associated macrophages (TAMs) and induce an anti-tumor immune response.
exoSTING (CDK-002) and exoIL-12 demonstrated favorable safety and tolerability profile at repeat doses tested and antitumor activity was observed in both injected and uninjected/distal lesions.
Codiak’s proprietary exoASO-STAT6 designed to enable the development of engineered exosome therapeutics for a wide spectrum of diseases and to manufacture them reproducibly and at scale to pharmaceutical standards.
Codiak’s proprietary engEx Platform is designed to enable the development of engineered exosome therapeutics for a wide spectrum of diseases and to manufacture them reproducibly and at scale to pharmaceutical standards.
Data demonstrated potential for exosome-based vaccine derived from exoVACC platform induce cross-neutralizing antibody protection against strains of coronavirus and antigen-specific and comprehensive immune response against structurally conserved region of coronavirus variant.
exoASO-STAT6 is an engineered exosome therapeutic candidate which selectively delivers antisense oligonucleotides to down-modulate STAT6 mRNA expression in TAMs. Precise targeting of STAT6 promotes the switch of TAMs to an M1, T cell attractive, anti-tumor phenotype.
exoSTING (CDK-002) is candidate engineered to incorporate a proprietary STING agonist inside the lumen of the exosome while expressing the exosomal protein, PTGFRN, on the exosome surface to facilitate specific uptake in tumor-resident antigen presenting cells.
Codiak has two programs in clinical development and expects to file an IND for exoASO-STAT6 – a novel exosome therapeutic carrying an antisense oligonucleotide (ASO) to target the transcription factor, STAT6 – by the end of the year.
ExoSTING is a novel engineered exosome therapeutic candidate currently being investigated in a Phase 1/2 clinical trial as a single agent for the treatment of multiple solid tumors.
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