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Find Clinical Drug Pipeline Developments & Deals by Codagenix
The funding will be used to advance the development of its CodaVax-DENV, a tetravalent live attenuated dengue vaccine program, to address the unmet needs in dengue prevention.
The net proceeds from the funding will be used by Codagenix for the advancement of Phase 2 study for CoviLiv, a live-attenuated intranasal vaccine candidate.
CodaVax™-RSV is a live-attenuated, intranasal vaccine candidate is developed for the prevention of disease caused by respiratory syncytial virus (RSV). The trial is being conducted under US IND and the FDA has also granted Fast Track designation.
Proceeds from the financing will support the clinical development of CodaVax™-RSV, an intranasal, live-attenuated vaccine candidate, for the prevention of respiratory syncytial virus (RSV) disease.
The Phase 1 dose escalation study of CodaVax-RSV evaluating safety and immune responses in healthy children aged six months to five years is expected to initiate in early 2023, immediately after this year's RSV season.
CoviLivTM is a live-attenuated, intranasal vaccine that expresses all SARS-CoV-2 proteins, not just spike, enabling induction of broad immunity to numerous viral antigens and potentially increasing efficacy against variants.
CodaVax-H1N1 is a universal influenza vaccine designed to induce protection against all strains of influenza by safely leveraging the unique and proven benefits of live-attenuated vaccines, which induce strong cellular immunity and durable antibody responses.
Preclinical data in animal models, demonstrated that CodaVax-RSV was significantly attenuated compared to natural RSV, capable of eliciting neutralizing antibody and cellular immune responses and protective against wild type challenge.
In recent Phase 1 data, CoviLiv (Covi-vac) induced strong cellular immune response as a primary vaccine in healthy adults against many conserved proteins in known variants of SARS-CoV-2.
Codagenix has also recently completed dosing for its Phase 1 placebo-controlled trial of COVI-VAC evaluating the safety and immune response of 3 dose levels of the vaccine in 48 healthy adults aged 18 to 30 years.
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