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BioSciences","pharmaFlowCategory":"DU","therapeuticArea":"Neurology","country":"U.S.A","productType":"Miscellaneous","year":"2018","type":"Inapplicable","leadProduct":"Bupivacaine","moa":"Sodium channel protein type IV alpha subunit","graph1":"Neurology","graph2":"Phase IV","graph3":"Cleveland Clinic","amount2":0,"highestDevelopmentShortName":"Ph IV","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Suspension","sponsorNew":"Cleveland Clinic \/ Pacira BioSciences","highestDevelopmentStatusID":"11","companyTruncated":"Cleveland Clinic \/ Pacira BioSciences"},{"orgOrder":0,"company":"Cleveland Clinic","sponsor":"Johnson & Johnson Innovative Medicine","pharmaFlowCategory":"DU","therapeuticArea":"Endocrinology","country":"U.S.A","productType":"HPAPI","year":"2016","type":"Inapplicable","leadProduct":"Canagliflozin","moa":"Sodium\/glucose cotransporter 2","graph1":"Endocrinology","graph2":"Phase IV","graph3":"Cleveland Clinic","amount2":0,"highestDevelopmentShortName":"Ph IV","therapeuticAreaShortName":"Endocrinology","amount2New":0,"dosageForm":"Capsule","sponsorNew":"Cleveland Clinic \/ Johnson & Johnson Innovative Medicine","highestDevelopmentStatusID":"11","companyTruncated":"Cleveland Clinic \/ Johnson & Johnson Innovative Medicine"},{"orgOrder":0,"company":"Cleveland Clinic","sponsor":"Eli Lilly","pharmaFlowCategory":"DU","therapeuticArea":"Neurology","country":"U.S.A","productType":"Radiolabeled Compound","year":"2014","type":"Inapplicable","leadProduct":"18-F Flortaucipir","moa":"Tau aggregation","graph1":"Neurology","graph2":"Phase III","graph3":"Cleveland Clinic","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Injection","sponsorNew":"Cleveland Clinic \/ Cleveland Clinic","highestDevelopmentStatusID":"10","companyTruncated":"Cleveland Clinic \/ Cleveland Clinic"},{"orgOrder":0,"company":"Cleveland Clinic","sponsor":"Astellas Pharma","pharmaFlowCategory":"DU","therapeuticArea":"Hematology","country":"U.S.A","productType":"Protein","year":"2010","type":"Inapplicable","leadProduct":"Alefacept","moa":"T-cell surface antigen CD2","graph1":"Hematology","graph2":"Phase I","graph3":"Cleveland Clinic","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Hematology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Cleveland Clinic \/ Astellas Pharma","highestDevelopmentStatusID":"6","companyTruncated":"Cleveland Clinic \/ Astellas Pharma"},{"orgOrder":0,"company":"Cleveland Clinic","sponsor":"Health Resources and Services Administration","pharmaFlowCategory":"DU","therapeuticArea":"Immunology","country":"U.S.A","productType":"Enzyme","year":"2010","type":"Inapplicable","leadProduct":"Alteplase","moa":"Tissue-type plasminogen activator","graph1":"Immunology","graph2":"Undisclosed","graph3":"Cleveland Clinic","amount2":0,"highestDevelopmentShortName":"Undisclosed","therapeuticAreaShortName":"Immunology","amount2New":0,"dosageForm":"Implant","sponsorNew":"Cleveland Clinic \/ Health Resources and Services Administration","highestDevelopmentStatusID":"1","companyTruncated":"Cleveland Clinic \/ Health Resources and Services Administration"},{"orgOrder":0,"company":"Cleveland Clinic","sponsor":"Bristol Myers Squibb","pharmaFlowCategory":"DU","therapeuticArea":"Immunology","country":"U.S.A","productType":"Protein","year":"2014","type":"Inapplicable","leadProduct":"Abatacept","moa":"T-lymphocyte activation antigen CD86 | T-lymphocyte activation antigen CD80","graph1":"Immunology","graph2":"Phase II","graph3":"Cleveland Clinic","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Immunology","amount2New":0,"dosageForm":"Injection","sponsorNew":"Cleveland Clinic \/ Bristol Myers Squibb","highestDevelopmentStatusID":"8","companyTruncated":"Cleveland Clinic \/ Bristol Myers Squibb"},{"orgOrder":0,"company":"Cleveland Clinic","sponsor":"Anixa Biosciences","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Vaccine","year":"2024","type":"Partnership","leadProduct":"Alpha-Lactalbumin-Based Vaccine","moa":"Undisclosed","graph1":"Oncology","graph2":"Phase I","graph3":"Cleveland Clinic","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Cleveland Clinic \/ Cleveland Clinic","highestDevelopmentStatusID":"6","companyTruncated":"Cleveland Clinic \/ Cleveland Clinic"},{"orgOrder":0,"company":"Cleveland Clinic","sponsor":"Cytocom","pharmaFlowCategory":"D","therapeuticArea":"Immunology","country":"U.S.A","productType":"Hormone","year":"2021","type":"Merger","leadProduct":"CYTO-200","moa":"Undisclosed","graph1":"Immunology","graph2":"Phase II\/ Phase III","graph3":"Cleveland Clinic","amount2":0,"highestDevelopmentShortName":"Ph II\/III","therapeuticAreaShortName":"Immunology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Cleveland Clinic \/ Cleveland Clinic","highestDevelopmentStatusID":"9","companyTruncated":"Cleveland Clinic \/ Cleveland Clinic"},{"orgOrder":0,"company":"Cleveland Clinic","sponsor":"GSK | Currax","pharmaFlowCategory":"DU","therapeuticArea":"Neurology","country":"U.S.A","productType":"Miscellaneous","year":"2010","type":"Inapplicable","leadProduct":"Pentamethylethane","moa":"Undisclosed","graph1":"Neurology","graph2":"Phase IV","graph3":"Cleveland Clinic","amount2":0,"highestDevelopmentShortName":"Ph IV","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Cleveland Clinic \/ GSK | Currax","highestDevelopmentStatusID":"11","companyTruncated":"Cleveland Clinic \/ GSK | Currax"},{"orgOrder":0,"company":"Cleveland Clinic","sponsor":"Nestle Health Sciences SA","pharmaFlowCategory":"DU","therapeuticArea":"Nutrition and Weight Loss","country":"U.S.A","productType":"Dietary Supplement","year":"2011","type":"Inapplicable","leadProduct":"Whole Grain","moa":"Undisclosed","graph1":"Nutrition and Weight Loss","graph2":"Undisclosed","graph3":"Cleveland Clinic","amount2":0,"highestDevelopmentShortName":"Undisclosed","therapeuticAreaShortName":"Nutrition & Weight Loss","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Cleveland Clinic \/ Nestle Health Sciences SA","highestDevelopmentStatusID":"1","companyTruncated":"Cleveland Clinic \/ Nestle Health Sciences SA"},{"orgOrder":0,"company":"Cleveland Clinic","sponsor":"Anixa Biosciences","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Undisclosed","year":"2021","type":"Inapplicable","leadProduct":"Undisclosed","moa":"Undisclosed","graph1":"Oncology","graph2":"Phase I","graph3":"Cleveland Clinic","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Cleveland Clinic \/ Anixa Biosciences","highestDevelopmentStatusID":"6","companyTruncated":"Cleveland Clinic \/ Anixa Biosciences"},{"orgOrder":0,"company":"Cleveland Clinic","sponsor":"TFF Pharmaceuticals","pharmaFlowCategory":"D","therapeuticArea":"Infections and Infectious Diseases","country":"U.S.A","productType":"Undisclosed","year":"2024","type":"Collaboration","leadProduct":"Undisclosed","moa":"Undisclosed","graph1":"Infections and Infectious Diseases","graph2":"Preclinical","graph3":"Cleveland Clinic","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Infectious Diseases","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Cleveland Clinic \/ Cleveland Clinic","highestDevelopmentStatusID":"4","companyTruncated":"Cleveland Clinic \/ Cleveland Clinic"}]

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                          Therapeutic Area by Lead Product

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                          Top Deals by Deal Size (USD bn)

                          01

                          Bio-Europe Autumn
                          Not Confirmed
                          Bio-Europe Autumn
                          Not Confirmed

                          Details : Carbidopa is a Other Small Molecule drug candidate, which is currently being evaluated in Phase IV clinical studies for the treatment of Parkinson Disease.

                          Product Name : Undisclosed

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          August 24, 2025

                          Lead Product(s) : Carbidopa

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase IV

                          Sponsor : Amneal Pharmaceuticals

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          02

                          Bio-Europe Autumn
                          Not Confirmed
                          Bio-Europe Autumn
                          Not Confirmed

                          Details : NeuroTherapia will use this funding primarily for the continued clinical development of NTRX-07, an orally available cannabinoid receptor agonist, for the treatment of Alzheimer's disease

                          Product Name : Undisclosed

                          Product Type : Miscellaneous

                          Upfront Cash : Undisclosed

                          August 06, 2024

                          Lead Product(s) : NTRX-07

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase I

                          Recipient : NeuroTherapia

                          Deal Size : $12.3 million

                          Deal Type : Series B Financing

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                          03

                          Bio-Europe Autumn
                          Not Confirmed
                          Bio-Europe Autumn
                          Not Confirmed

                          Details : TFF collaborates with Cleveland to advance multiple multivalent universal influenza vaccines, which are being evaluated in early-stage clinical trials to protect against seasonal & pandemic viruses.

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : Undisclosed

                          May 20, 2024

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Preclinical

                          Recipient : TFF Pharmaceuticals

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

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                          04

                          Bio-Europe Autumn
                          Not Confirmed
                          Bio-Europe Autumn
                          Not Confirmed

                          Details : Under the expanded partnership, companies will co-develop vaccines for cancers. Cleveland Clinic is conducting a Phase 1 trial for triple-negative breast cancer.

                          Product Name : Undisclosed

                          Product Type : Vaccine

                          Upfront Cash : Undisclosed

                          May 08, 2024

                          Lead Product(s) : Alpha-Lactalbumin-Based Vaccine

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Recipient : Anixa Biosciences

                          Deal Size : Undisclosed

                          Deal Type : Partnership

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                          05

                          Bio-Europe Autumn
                          Not Confirmed
                          Bio-Europe Autumn
                          Not Confirmed

                          Details : Sugammadex is a Other Small Molecule drug candidate, which is currently being evaluated in clinical studies for the treatment of Neuromuscular Blockade.

                          Product Name : Undisclosed

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          November 18, 2023

                          Lead Product(s) : Sugammadex Sodium

                          Therapeutic Area : Musculoskeletal

                          Highest Development Status : Undisclosed

                          Sponsor : Merck & Co

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          06

                          Bio-Europe Autumn
                          Not Confirmed
                          Bio-Europe Autumn
                          Not Confirmed

                          Details : Artesunate is a Other Small Molecule drug candidate, which is currently being evaluated in phase II clinical studies for the treatment of Vulvar Diseases.

                          Product Name : Undisclosed

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          October 10, 2023

                          Lead Product(s) : Artesunate

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Phase II

                          Recipient : Frantz Viral Therapeutics

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          07

                          Bio-Europe Autumn
                          Not Confirmed
                          Bio-Europe Autumn
                          Not Confirmed

                          Details : The agreement aims to conduct a phase 1 trial of Bryostatin-1, a small molecule that works by activating protein kinase C, in multiple sclerosis (MS).

                          Product Name : Undisclosed

                          Product Type : Miscellaneous

                          Upfront Cash : Undisclosed

                          July 19, 2023

                          Lead Product(s) : Bryostatin-1

                          Therapeutic Area : Neurology

                          Highest Development Status : Preclinical

                          Sponsor : Synaptogenix

                          Deal Size : Undisclosed

                          Deal Type : Agreement

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                          08

                          Bio-Europe Autumn
                          Not Confirmed
                          Bio-Europe Autumn
                          Not Confirmed

                          Details : By developing ovarian cancer vaccine that target alpha-lactalbumin and AMHR2-ED, immune system can destroy breast cancer cells and ovarian cancer cells, respectively, as they arise and ultimately prevent tumors from forming.

                          Product Name : Undisclosed

                          Product Type : Vaccine

                          Upfront Cash : Inapplicable

                          September 12, 2022

                          Lead Product(s) : Ovarian Cancer Vaccine

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Recipient : Anixa Biosciences

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          09

                          Bio-Europe Autumn
                          Not Confirmed
                          Bio-Europe Autumn
                          Not Confirmed

                          Details : Positive Phase II trial reported for AR1001, the results confirmed the possibility of developing a unique oral disease-modifying treatment for AD that improves cognitive function. The Company will complete Phase III clinical trials of AR1001 within the n...

                          Product Name : Undisclosed

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          December 20, 2021

                          Lead Product(s) : Mirodenafil

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase II

                          Recipient : AriBio

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          10

                          Bio-Europe Autumn
                          Not Confirmed
                          Bio-Europe Autumn
                          Not Confirmed

                          Details : The investigational vaccine targets a breast-specific lactation protein, α-lactalbumin, which is no longer found post-lactation in normal, aging tissues but is present in the majority of triple-negative breast cancers.

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : Inapplicable

                          October 26, 2021

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Anixa Biosciences

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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