Quotient Sciences Quotient Sciences

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            Myalepta (metreleptin) is a USFDA approved leptin receptor activator, which is now approved by Health Canada for the treatment of congenital or acquired generalized lipodystrophy.

            Lead Product(s): Metreleptin

            Therapeutic Area: Genetic Disease Product Name: Myalepta

            Highest Development Status: Approved Product Type: Peptide

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable February 05, 2024

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            The agreement aims to develop, manufacture, and commercialise OHB-607 (mecasermin rinfabate), a recombinant version of insulin-like growth factor-1 (IGF-1), being developed to treat complications of extremely premature birth.

            Lead Product(s): Mecasermin Rinfabate

            Therapeutic Area: Pulmonary/Respiratory Diseases Product Name: OHB-607

            Highest Development Status: Phase II Product Type: Large molecule

            Recipient: Oak Hill Bio

            Deal Size: Undisclosed Upfront Cash: Undisclosed

            Deal Type: Licensing Agreement January 09, 2024

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            Filsuvez (birch triterpenes) is a topical gel which is approved for the treatment of wounds associated with dystrophic and junctional epidermolysis bullosa.

            Lead Product(s): Birch Triterpenes

            Therapeutic Area: Genetic Disease Product Name: Filsuvez

            Highest Development Status: Approved Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable December 19, 2023

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            The agreement aims to develop, manufacture, and commercialise outside China and adjacent territories, HSK31858, an oral, potent, and highly selective small molecule DPP1 inhibitor with the potential to be an anti-inflammatory agent in bronchiectasis.

            Lead Product(s): HSK31858

            Therapeutic Area: Pulmonary/Respiratory Diseases Product Name: HSK31858

            Highest Development Status: Phase II Product Type: Small molecule

            Recipient: Haisco Pharmaceutical

            Deal Size: Undisclosed Upfront Cash: Undisclosed

            Deal Type: Licensing Agreement November 20, 2023

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            Under the terms of the agreement, Chiesi Group acquired all assets and certain liabilities related to Raxone (idebenone) in all indications worldwide, including Raxone in leber hereditary optic neuropathy (LHON).

            Lead Product(s): Idebenone

            Therapeutic Area: Genetic Disease Product Name: Raxone

            Highest Development Status: Approved Product Type: Small molecule

            Recipient: Santhera Pharmaceuticals

            Deal Size: $104.0 million Upfront Cash: $49.2 million

            Deal Type: Divestment July 31, 2023

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            Elfabrio (pegunigalsidase alfa-iwxj) is a PEGylated enzyme replacement therapy (ERT) for the treatment of adult patients with Fabry disease. It is a recombinant human α–Galactosidase–A enzyme expressed in plant-cell culture that is designed to provide a long half-life.

            Lead Product(s): Pegunigalsidase alfa-iwxj

            Therapeutic Area: Genetic Disease Product Name: Elfabrio

            Highest Development Status: Approved Product Type: Large molecule

            Recipient: Protalix BioTherapeutics

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable May 10, 2023

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            PRX-102 (pegunigalsidase alfa), EC authorized, is a novel PEGylated, covalently crosslinked form of α-galactosidase-A developed as enzyme replacement therapy for fabry disease, was designed to increase plasma half-life and reduce immunogenicity, thereby enhancing efficacy.

            Lead Product(s): Pegunigalsidase alfa

            Therapeutic Area: Genetic Disease Product Name: PRX-102

            Highest Development Status: Approved Product Type: Large molecule

            Recipient: Protalix BioTherapeutics

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable May 05, 2023

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            The acquisition expands chiesi’s rare disease medicine portfolio by adding Amryt's pipeline including, Filsuvez (oleogel-S10), a topical therapeutic gel, is a potential treatment for the cutaneous manifestations of Epidermolysis Bullosa.

            Lead Product(s): Oleogel-S10

            Therapeutic Area: Rare Diseases and Disorders Product Name: Filsuvez

            Highest Development Status: Approved Product Type: Small molecule

            Recipient: Amryt Pharma

            Deal Size: $1,480.0 million Upfront Cash: $1,250.0 million

            Deal Type: Acquisition April 12, 2023

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            Ferriprox™ (deferiprone) is a chelating agent with an affinity for ferric ion (iron III), being developed for the treatment of patients with transfusional iron overload due to thalassemia syndromes.

            Lead Product(s): Deferiprone

            Therapeutic Area: Genetic Disease Product Name: Ferriprox

            Highest Development Status: Approved Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable March 31, 2023

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            Details:

            Under the terms of the collaboration, Affibody and Chiesi Group will collaborate closely to progress up to three programs based on Affibody® molecules against undisclosed targets for respiratory diseases.

            Lead Product(s): Undisclosed

            Therapeutic Area: Pulmonary/Respiratory Diseases Product Name: Undisclosed

            Highest Development Status: Discovery Product Type: Large molecule

            Recipient: Affibody

            Deal Size: $214.0 million Upfront Cash: Undisclosed

            Deal Type: Collaboration March 07, 2023

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