
 
													 
									 
															 
															Year
 
															DEALS // DEV.
 
															Country
 
															 
															Therapeutic Area
 
															Study Phase
 
															Deal Type
 
															Product Type
 
															Dosage Form
 
															Lead Product
 
															Target

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Lead Product(s) : AZD1656
Therapeutic Area : Nephrology
Study Phase : Phase II
Recipient : Conduit Pharma
Deal Size : Undisclosed
Deal Type : Collaboration
Conduit Pharma, Charles River Partner on Systemic Lupus Erythematosus Model
Details : Conduit will leverage Charles River’s expertise in immunology and preclinical research to help in development of AZD1656 for Lupus Nephritis.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Undisclosed
February 13, 2025
Lead Product(s) : AZD1656
Therapeutic Area : Nephrology
Highest Development Status : Phase II
Recipient : Conduit Pharma
Deal Size : Undisclosed
Deal Type : Collaboration

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Lead Product(s) : CYWC628
Therapeutic Area : Podiatry
Study Phase : Preclinical
Sponsor : FibroBiologics
Deal Size : Undisclosed
Deal Type : Collaboration
FibroBiologics and Charles River Partner for Fibroblast Cell-Based Therapies
Details : The collaboration aims to develop and manufacture FibroBiologics’ therapeutic master cell bank, working cell bank, and fibroblast-based spheroids product, CYWC628, for diabetic foot ulcer (DFU).
Product Name : Undisclosed
Product Type : Cell & Gene Therapy
Upfront Cash : Undisclosed
October 18, 2024
Lead Product(s) : CYWC628
Therapeutic Area : Podiatry
Highest Development Status : Preclinical
Sponsor : FibroBiologics
Deal Size : Undisclosed
Deal Type : Collaboration

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Lead Product(s) : Undisclosed
Therapeutic Area : Neurology
Study Phase : Discovery Platform
Sponsor : H. Lundbeck AS
Deal Size : Undisclosed
Deal Type : Agreement
Charles River and Lundbeck Use AI To Discover Neurological Disease Drugs
Details : The agreement aims to advance the discovery of novel drugs for neurological disease by utilizing Logica which translates biological insights into optimized preclinical candidates.
Product Name : Undisclosed
Product Type : Undisclosed
Upfront Cash : Undisclosed
October 02, 2024
Lead Product(s) : Undisclosed
Therapeutic Area : Neurology
Highest Development Status : Discovery Platform
Sponsor : H. Lundbeck AS
Deal Size : Undisclosed
Deal Type : Agreement

Charles River and CEBINA Partner On Cutting-Edge Neuroscience Research
Details : Charles River and CEBINA will accelerate innovative approaches to treating neurodegenerative diseases using Charles' extensive expertise in drug discovery and development in the CNS field.
Product Name : Undisclosed
Product Type : Undisclosed
Upfront Cash : Undisclosed
September 17, 2024

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Lead Product(s) : Undisclosed
Therapeutic Area : Rare Diseases and Disorders
Study Phase : Preclinical
Sponsor : FOXG1 Research Foundation
Deal Size : Undisclosed
Deal Type : Collaboration
Charles River Partners with FOXG1 Research Foundation to Advance CGT for Rare Diseases
Details : Charles River will provide FRF with access to extensive cell and gene therapy expertise and generate materials for FRF’s Phase I-II adeno-associated viral (AAV) vector-based gene therapy.
Product Name : Undisclosed
Product Type : Undisclosed
Upfront Cash : Undisclosed
July 30, 2024
Lead Product(s) : Undisclosed
Therapeutic Area : Rare Diseases and Disorders
Highest Development Status : Preclinical
Sponsor : FOXG1 Research Foundation
Deal Size : Undisclosed
Deal Type : Collaboration

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Lead Product(s) : Undisclosed
Therapeutic Area : Oncology
Study Phase : Discovery Platform
Recipient : Ability Biologics
Deal Size : $18.0 million
Deal Type : Financing
Ability Biologics Closes $18 Million Seed Funding Extension for Immunomodulators
Details : The financing aims to support AI in therapeutic discovery, focusing its platform on discovering and developing potent and selective antibody therapeutics for cancer and immune-related disorders.
Product Name : Undisclosed
Product Type : Undisclosed
Upfront Cash : Undisclosed
June 18, 2024
Lead Product(s) : Undisclosed
Therapeutic Area : Oncology
Highest Development Status : Discovery Platform
Recipient : Ability Biologics
Deal Size : $18.0 million
Deal Type : Financing

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Lead Product(s) : Undisclosed
Therapeutic Area : Oncology
Study Phase : Preclinical
Recipient : Captain T Cell
Deal Size : Undisclosed
Deal Type : Agreement
Charles River, Captain T Cell Sign Plasmid DNA & Viral Vector Production Program Agreement
Details : Captain T Cell will access CDMO capabilities and advisory services as it prepares to manufacture TCR-T cell therapy for solid tumor patients in Phase 1 trials.
Product Name : Undisclosed
Product Type : Undisclosed
Upfront Cash : Undisclosed
June 17, 2024
Lead Product(s) : Undisclosed
Therapeutic Area : Oncology
Highest Development Status : Preclinical
Recipient : Captain T Cell
Deal Size : Undisclosed
Deal Type : Agreement

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Lead Product(s) : AXV-101
Therapeutic Area : Rare Diseases and Disorders
Study Phase : Preclinical
Sponsor : Axovia Therapeutics
Deal Size : Undisclosed
Deal Type : Collaboration
Charles River & Axovia Partner to Support Development of Gene Therapies for Ciliopathies
Details : The collaboration aims to support the development of Axovia’s gene therapies, including AXV101, for ciliopathies, including Bardet-Biedl Syndrome, a condition with limited options or no cure.
Product Name : Undisclosed
Product Type : Cell & Gene Therapy
Upfront Cash : Undisclosed
April 09, 2024
Lead Product(s) : AXV-101
Therapeutic Area : Rare Diseases and Disorders
Highest Development Status : Preclinical
Sponsor : Axovia Therapeutics
Deal Size : Undisclosed
Deal Type : Collaboration

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Lead Product(s) : NT-Z001
Therapeutic Area : Neurology
Study Phase : IND Enabling
Sponsor : Navega Therapeutics
Deal Size : Undisclosed
Deal Type : Collaboration
Charles River and Navega Announce Gene Therapy Manufacturing Collaboration
Details : The collaboration supports Navega's NT-Z001 for chronic pain in rare diseases like small fiber neuropathy and primary erythromelalgia.
Product Name : Undisclosed
Product Type : Cell & Gene Therapy
Upfront Cash : Undisclosed
March 14, 2024
Lead Product(s) : NT-Z001
Therapeutic Area : Neurology
Highest Development Status : IND Enabling
Sponsor : Navega Therapeutics
Deal Size : Undisclosed
Deal Type : Collaboration

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Lead Product(s) : Exagamglogene Autotemcel
Therapeutic Area : Genetic Disease
Study Phase : Approved FDF
Sponsor : Vertex Pharmaceuticals
Deal Size : Undisclosed
Deal Type : Collaboration
Details : Under the agreement, Charles River will manufacture Vertex’s CASGEVY (exagamglogene autotemcel) therapy, the world’s first gene-edited therapy targeting severe sickle cell disease.
Product Name : Casgevy
Product Type : Cell & Gene Therapy
Upfront Cash : Undisclosed
December 18, 2023
Lead Product(s) : Exagamglogene Autotemcel
Therapeutic Area : Genetic Disease
Highest Development Status : Approved FDF
Sponsor : Vertex Pharmaceuticals
Deal Size : Undisclosed
Deal Type : Collaboration

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