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Find Clinical Drug Development Pipelines & Deals | PipelineProspector
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Details:
TA-8995 (obicetrapib) is a next-generation, non statin, oral once-daily, low-dose CETP inhibitor having the potential for lowering LDL-C, if approved. It is currently being investigated in combination with ezetimibe as an adjunct to high-intensity statin therapy.
Lead Product(s):
Obicetrapib ,Ezetimibe
Therapeutic Area: Cardiology/Vascular Diseases
Product Name: TA-8995
Highest Development Status: Phase II
Product Type: Small molecule
Partner/Sponsor/Collaborator:
Not Applicable
Deal Size: Not Applicable
Upfront Cash: Not Applicable
Deal Type: Not Applicable
January 17, 2023
Details:
Obicetrapib (TA-8995) is an oral, low-dose and once-daily CETP inhibitor, initially in development for patients at high risk for cardiovascular disease as an adjunct to maximally tolerated statin therapy, both as a monotherapy and in a fixed-dose combination with ezetimibe.
Lead Product(s):
Obicetrapib ,Ezetimibe
Therapeutic Area: Cardiology/Vascular Diseases
Product Name: TA-8995
Highest Development Status: Phase II
Product Type: Small molecule
Partner/Sponsor/Collaborator:
Not Applicable
Deal Size: Not Applicable
Upfront Cash: Not Applicable
Deal Type: Not Applicable
October 05, 2022
Details:
ROSE2 study evaluates obicetrapib, a novel cholesteryl ester transfer protein (CETP) inhibitor, in combination with ezetimibe, a cholesterol absorption inhibitor, in patients who are currently receiving high-intensity statin therapy.
Lead Product(s):
Obicetrapib ,Ezetimibe
Therapeutic Area: Cardiology/Vascular Diseases
Product Name: TA-8995
Highest Development Status: Phase II
Product Type: Small molecule
Partner/Sponsor/Collaborator:
Not Applicable
Deal Size: Not Applicable
Upfront Cash: Not Applicable
Deal Type: Not Applicable
April 05, 2022
Details:
Results of ROSE study demonstrated that patients on statin therapy who received 5mg of obicetrapib saw a reduction in LDL-c of 42% and patients who were part of the 10mg cohort experienced 51% reduction v/s baseline, while the placebo experienced 7% reduction v/s baseline.
Lead Product(s):
Obicetrapib
Therapeutic Area: Cardiology/Vascular Diseases
Product Name: TA-8995
Highest Development Status: Phase II
Product Type: Small molecule
Partner/Sponsor/Collaborator:
Not Applicable
Deal Size: Not Applicable
Upfront Cash: Not Applicable
Deal Type: Not Applicable
November 13, 2021
Details:
ROSE was designed as a placebo-controlled, double-blind, randomized, Phase 2 dose-finding study to evaluate the efficacy, safety, and tolerability of obicetrapib as an adjunct to high-intensity statin therapy.
Lead Product(s):
Obicetrapib
Therapeutic Area: Cardiology/Vascular Diseases
Product Name: TA-8995
Highest Development Status: Phase II
Product Type: Small molecule
Partner/Sponsor/Collaborator:
Not Applicable
Deal Size: Not Applicable
Upfront Cash: Not Applicable
Deal Type: Not Applicable
July 28, 2021
Details:
Funding will support initiation and finalization of Phase 3 development of obicetrapib, a potent ApoB and LDL-c lowering small molecule drug, intended for patients not well-controlled on statins.
Lead Product(s):
Obicetrapib
Therapeutic Area: Cardiology/Vascular Diseases
Product Name: TA-8995
Highest Development Status: Phase II
Product Type: Small molecule
Partner/Sponsor/Collaborator:
Morningside Ventures
Deal Size: $196.0 million
Upfront Cash: Undisclosed
Deal Type: Series A Financing
January 14, 2021