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Find Approved Drugs for Cardiology/Vascular Diseases in Clinical Development in JAPAN

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            Lead Product(s): Isosorbide Dinitrate

            Therapeutic Area: Cardiology/Vascular Diseases Product Name: Frandol

            Highest Development Status: Approved Product Type: Small molecule

            Partner/Sponsor/Collaborator: Astellas Pharma

            Deal Size: Undisclosed Upfront Cash: Undisclosed

            Deal Type: Termination April 05, 2021

            Details:

            In accordance with this agreement TOA EIYO will independently sell and provide information on all 18 products such as Bisono® tape for treatment of hypertension and atrial fibrillation and Frandol® tablets and tape for treatment of ischemic heart disease.

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            Lead Product(s): Urapidil Hydrochloride

            Therapeutic Area: Cardiology/Vascular Diseases Product Name: Ebrantil

            Highest Development Status: Approved Product Type: Small molecule

            Partner/Sponsor/Collaborator: Hasten

            Deal Size: $322.0 million Upfront Cash: Undisclosed

            Deal Type: Divestment December 21, 2020

            Details:

            The portfolio to be divested to Hasten includes cardiovascular and metabolism products sold in mainland China which includes Ebrantil®.

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            Lead Product(s): Bempedoic Acid,Ezetimibe

            Therapeutic Area: Cardiology/Vascular Diseases Product Name: Nustendi

            Highest Development Status: Approved Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable December 16, 2020

            Details:

            Bempedoic acid and its fixed combination drug product with ezetimibe both deliver significant reductions in LDL-C when added to a statin or other lipid-lowering therapies.

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            Lead Product(s): Edoxaban

            Therapeutic Area: Cardiology/Vascular Diseases Product Name: Du-176b

            Highest Development Status: Approved Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable September 11, 2020

            Details:

            This application is based on results from the Japanese phase 3 clinical trial (ELDERCARE-AF Study) in 984 non-valvular atrial fibrillation patients of 80 years and above with a high bleeding risk and who are ineligible for other available anticoagulation therapies.