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    [{"orgOrder":0,"company":"BridgeBio Oncology Therapeutics","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Miscellaneous","year":"2024","type":"Inapplicable","leadProduct":"BBO-8520","moa":"GTP","graph1":"Oncology","graph2":"Phase I","graph3":"BridgeBio Oncology Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"BridgeBio Oncology Therapeutics \/ Undisclosed","highestDevelopmentStatusID":"6","companyTruncated":"BridgeBio Oncology Therapeutics \/ Undisclosed"},{"orgOrder":0,"company":"BridgeBio Oncology Therapeutics","sponsor":"Helix Acquisition Corp. 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    Find Clinical Drug Pipeline Developments & Deals by BridgeBio Oncology Therapeutics

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                            01

                            BridgeBio Oncology Therapeutics

                            U.S.A arrow
                            AIChE Annual Meeting
                            Not Confirmed

                            BridgeBio Oncology Therapeutics

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                            AIChE Annual Meeting
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                            Lead Product(s) : BBO-8520,Pembrolizumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Helix Acquisition Corp. II

                            Deal Size : Undisclosed

                            Deal Type : Merger

                            DEALS_DEV arrow-down

                            BBOT Debuts as a Publicly Traded Company Focused on RAS-Pathway Malignances

                            Details : The combined company will focus on the acceleration of pipeline clinical development, which includes BBO-8520. It is being evaluated for the treatment of KRASG12C mutant non-small cell lung cancer.

                            Product Name : BBO-8520

                            Product Type : Miscellaneous

                            Upfront Cash : Undisclosed

                            August 11, 2025

                            Lead Product(s) : BBO-8520,Pembrolizumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Helix Acquisition Corp. II

                            Deal Size : Undisclosed

                            Deal Type : Merger

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                            02

                            BridgeBio Oncology Therapeutics

                            U.S.A arrow
                            AIChE Annual Meeting
                            Not Confirmed

                            BridgeBio Oncology Therapeutics

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                            AIChE Annual Meeting
                            Not Confirmed
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                            Lead Product(s) : BBO-11818

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            BBO-11818 in Adult Subjects With KRAS Mutant Cancer

                            Details : BBO-11818 is a Other Small Molecule drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of Carcinoma, Non-Small-Cell Lung.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            April 08, 2025

                            Lead Product(s) : BBO-11818

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            03

                            BridgeBio Oncology Therapeutics

                            U.S.A arrow
                            AIChE Annual Meeting
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                            BridgeBio Oncology Therapeutics

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                            AIChE Annual Meeting
                            Not Confirmed
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                            Lead Product(s) : BBO-11818,Pembrolizumab,Carboplatin

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            BBOT Announces First Patient Dosed with BBO-11818 in Phase 1 for Advanced Solid Tumors

                            Details : BBO-11818 is an orally bioavailable small molecule dual inhibitor that directly binds to both the “ON” and “OFF” states of KRAS. Currently, It is being evaluated for KRAS-mutated cancer.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            April 01, 2025

                            Lead Product(s) : BBO-11818,Pembrolizumab,Carboplatin

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            04

                            BridgeBio Oncology Therapeutics

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                            AIChE Annual Meeting
                            Not Confirmed

                            BridgeBio Oncology Therapeutics

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                            AIChE Annual Meeting
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                            Lead Product(s) : BBO-8520,Pembrolizumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Helix Acquisition Corp. II

                            Deal Size : Undisclosed

                            Deal Type : Merger

                            DEALS_DEV arrow-down

                            BBOT, Helix Acquisition Announce Merger to Advance RAS and PI3Kα Therapies

                            Details : The combined company will focus on the acceleration of pipeline clinical development, which includes BBO-8520. It is being evaluated for the treatment of KRASG12C mutant non-small cell lung cancer.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Undisclosed

                            February 28, 2025

                            Lead Product(s) : BBO-8520,Pembrolizumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Helix Acquisition Corp. II

                            Deal Size : Undisclosed

                            Deal Type : Merger

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                            05

                            BridgeBio Oncology Therapeutics

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                            AIChE Annual Meeting
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                            BridgeBio Oncology Therapeutics

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                            AIChE Annual Meeting
                            Not Confirmed
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                            Lead Product(s) : BBO-8520,Pembrolizumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            BridgeBio Oncology Receives FDA Fast Track for BBO-8520 in NSCLC

                            Details : BBO-8520 is a first-in-class direct inhibitor of KRASG12C (ON). It is being evaluated for the treatment of KRASG12C mutant non-small cell lung cancer.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            January 09, 2025

                            Lead Product(s) : BBO-8520,Pembrolizumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            06

                            BridgeBio Oncology Therapeutics

                            U.S.A arrow
                            AIChE Annual Meeting
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                            BridgeBio Oncology Therapeutics

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                            Lead Product(s) : BBO-10203,Trastuzumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            BridgeBio Doses First Patient with BBO-10203 in Phase 1 BREAKER-101 Trial

                            Details : BBO-10203 is a first-in-class orally bioavailable RAS:PI3Ka breaker that blocks the interaction between RAS and PI3Kα to inhibit PI3Kα-AKT signaling in tumors.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            October 30, 2024

                            Lead Product(s) : BBO-10203,Trastuzumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            07

                            BridgeBio Oncology Therapeutics

                            U.S.A arrow
                            AIChE Annual Meeting
                            Not Confirmed

                            BridgeBio Oncology Therapeutics

                            U.S.A arrow
                            AIChE Annual Meeting
                            Not Confirmed
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                            Lead Product(s) : BBO-10203

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Open-Label Study of BBO-10203 in Subjects With Advanced Solid Tumors

                            Details : BBO-10203 is a Other Small Molecule drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of Neoplasms.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            October 03, 2024

                            Lead Product(s) : BBO-10203

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            08

                            BridgeBio Oncology Therapeutics

                            U.S.A arrow
                            AIChE Annual Meeting
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                            BridgeBio Oncology Therapeutics

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                            AIChE Annual Meeting
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                            Lead Product(s) : BBO-8520

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Open-label Study of BBO-8520 in Adult Subjects With KRASG12C Non-small Cell Lung Cancer

                            Details : BBO-8520 is a Other Small Molecule drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of Carcinoma, Non-Small-Cell Lung.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            April 02, 2024

                            Lead Product(s) : BBO-8520

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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