CSBio CSBio

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Applicable","newsHeadline":"BioCryst Begins Enrollment in Proof-of-Concept Trial to Confirm Safe, Effective, Once-daily Dose of Oral Factor D Inhibitor, BCX10013","therapeuticArea":"Genetic Disease","highestDevelopmentStatus":"Phase I","country":"U.S.A","productType":"Small molecule","productStatus":"New Molecular Entity","date":"October 2023","url1":"","url2":"","graph1":"Genetic Disease","graph2":"Phase I"},{"orgOrder":0,"company":"BioCryst Pharmaceuticals","sponsor":"Clearside Biomedical","pharmaFlowCategory":"D","amount":"$82.5 million","upfrontCash":"$5.0 million","newsHeadline":"BioCryst and Clearside Biomedical Enter Partnership to Develop Avoralstat for Diabetic Macular Edema Using Clearside\u2019s Proprietary SCS Microinjector\u00ae","therapeuticArea":"Ophthalmology","highestDevelopmentStatus":"Preclinical","country":"U.S.A","productType":"Small molecule","productStatus":"New Molecular Entity","date":"November 2023","url1":"","url2":"","graph1":"Ophthalmology","graph2":"Preclinical"},{"orgOrder":0,"company":"BioCryst Pharmaceuticals","sponsor":"Not Applicable","pharmaFlowCategory":"DU","amount":"Not Applicable","upfrontCash":"Not Applicable","newsHeadline":"BioCryst Launches ORLADEYO\u00ae (berotralstat) in Italy","therapeuticArea":"Genetic Disease","highestDevelopmentStatus":"Approved","country":"U.S.A","productType":"Small molecule","productStatus":"Approved","date":"February 2024","url1":"","url2":"","graph1":"Genetic Disease","graph2":"Approved"}]

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            Details:

            Orladeyo (berotralstat) is a plasma kallikrein inhibitor indicated for prophylaxis to prevent attacks of hereditary angioedema in adults and pediatric patients 12 years and older.

            Lead Product(s): Berotralstat Dihydrochloride

            Therapeutic Area: Genetic Disease Product Name: Orladeyo

            Highest Development Status: Approved Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable February 19, 2024

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            Under the agreement, BioCryst to develop its investigational plasma kallikrein inhibitor, avoralstat, with Clearside’s SCS Microinjector® to deliver avoralstat directly to the back of the eye through the suprachoroidal space to treat patients with diabetic macular edema (DME).

            Lead Product(s): Avoralstat

            Therapeutic Area: Ophthalmology Product Name: BCX4161

            Highest Development Status: Preclinical Product Type: Small molecule

            Recipient: Clearside Biomedical

            Deal Size: $82.5 million Upfront Cash: $5.0 million

            Deal Type: Licensing Agreement November 06, 2023

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            BCX10013 as a potential best-in-class, once-daily, oral Factor D inhibitor for multiple complement-mediated diseases. It is being investigated for paroxysmal nocturnal hemoglobinuria and other complement-mediated diseases.

            Lead Product(s): BCX10013

            Therapeutic Area: Genetic Disease Product Name: BCX10013

            Highest Development Status: Phase I Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable October 26, 2023

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            Orladeyo® (berotralstat) is the first and only oral therapy designed to prevent attacks of HAE in adult and pediatric patients 12 years and older. One capsule per day works to prevent HAE attacks by decreasing the activity of plasma kallikrein.

            Lead Product(s): Berotralstat

            Therapeutic Area: Genetic Disease Product Name: Orladeyo

            Highest Development Status: Approved Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable September 18, 2023

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            Under the collaboration, Er-Kim Pharmaceuticals will commercialize Orladeyo (berotralstat), the first and only oral therapy designed specifically to prevent attacks of hereditary angioedema (HAE) in adult and pediatric patients 12 years and older, in Turkey.

            Lead Product(s): Berotralstat

            Therapeutic Area: Genetic Disease Product Name: Orladeyo

            Highest Development Status: Approved Product Type: Small molecule

            Recipient: Erkim

            Deal Size: Undisclosed Upfront Cash: Undisclosed

            Deal Type: Collaboration July 19, 2023

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            Details:

            Orladeyo® (berotralstat) is the first and only oral therapy designed to prevent attacks of HAE in adult and pediatric patients 12 years and older. One capsule per day works to prevent HAE attacks by decreasing the activity of plasma kallikrein.

            Lead Product(s): Berotralstat

            Therapeutic Area: Genetic Disease Product Name: Orladeyo

            Highest Development Status: Approved Product Type: Small molecule

            Partner/Sponsor/Collaborator: Pint Pharma

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable May 22, 2023

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            Details:

            Orladeyo® (berotralstat) is the first and only oral therapy designed specifically to prevent attacks of hereditary angioedema (HAE) by decreasing the activity of plasma kallikrein in adult and pediatric patients 12 years and older.

            Lead Product(s): Berotralstat

            Therapeutic Area: Genetic Disease Product Name: Orladeyo

            Highest Development Status: Approved Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable February 03, 2023

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            Details:

            Orladeyo® (berotralstat) is the first and only oral therapy designed to prevent attacks of HAE in adult and pediatric patients 12 years and older. One capsule per day works to prevent HAE attacks by decreasing the activity of plasma kallikrein.

            Lead Product(s): Berotralstat

            Therapeutic Area: Genetic Disease Product Name: Orladeyo

            Highest Development Status: Phase III Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable January 26, 2023

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            Details:

            Under the terms of the agreement, Swixx will be responsible for commercializing ORLADEYO in 15 markets within CEE. Orladeyo (berotralstat) is the first and only oral therapy designed specifically to prevent attacks of HAE in adult and pediatric patients 12 years and older.

            Lead Product(s): Berotralstat

            Therapeutic Area: Genetic Disease Product Name: Orladeyo

            Highest Development Status: Approved Product Type: Small molecule

            Partner/Sponsor/Collaborator: Swixx BioPharma

            Deal Size: Undisclosed Upfront Cash: Undisclosed

            Deal Type: Collaboration January 23, 2023

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            Details:

            BCX10013 as a potential best-in-class, once-daily, oral Factor D inhibitor for multiple complement-mediated diseases. It is being investigated for paroxysmal nocturnal hemoglobinuria and other complement-mediated diseases.

            Lead Product(s): BCX10013

            Therapeutic Area: Genetic Disease Product Name: BCX10013

            Highest Development Status: Phase I Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable January 09, 2023

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