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Find Clinical Drug Pipeline Developments & Deals by BioAegis Therapeutics
Rhu-pGSN (gelsolin) is a recombinant protein which acts as IL-1β inhibitor. It is being evaluated for the treatment of acute respiratory distress syndrome.
The funding will be used to advance recombinant human gelsolin (rhu-pGSN), a master regulator of the innate immune system, as a treatment for patients with for moderate-to-severe acute respiratory distress syndrome (ARDS).
Plasma gelsolin (pGSN) is a naturally occurring human protein that is an important component of the innate immune system. Plasma gelsolin is critically depleted in ARDS patients and has been shown to address both injurious and infectious inflammation.
This funding will accelerate the expansion of BioAegis’ pipeline with new indications as the Company pursues its US Phase 2 program in severe pneumonia. The funds will also be used to further scale up manufacturing to support the development of secondary indications.
Lead Product(s):
Recombinant Human Plasma Gelsolin
Supplementing human gelsolin with recombinant form (rhu-pGSN) is host-directed approach to treating inflammatory and infectious diseases. Gelsolin, naturally occurring human protein that is abundant in healthy individuals, is a key component of body’s innate immune system.
Lead Product(s):
Recombinant Human Plasma Gelsolin
Recombinant human plasma gelsolin is an ancient, highly conserved human protein that is a highly abundant plasma protein in healthy individuals. Its role is to keep inflammation localized to the site of injury and to boost the body’s ability to clear pathogens.
Lead Product(s):
Recombinant Human Plasma Gelsolin
Rhu-pGSN is a broad-acting threat-agnostic product that improves immune cell function at sites of injury by enhancing pathogen killing while also resolving inflammation.
Lead Product(s):
Recombinant Human Plasma Gelsolin
Supplementation with rhu-pGSN mitigates the observed vascular pathology. Gelsolin is non-immunosuppressive unlike current treatments to quell inflammatory cytokines.
Lead Product(s):
Recombinant human plasma gelsolin
The study assesses rhu-pGSN, and its ability to regulate the overactive inflammatory response often responsible for causing lung damage and death in COVID-19 patients.
Lead Product(s):
Recombinant human plasma gelsolin
The compelling data from this NIH sponsored study show the potential of gelsolin to not only improve survival, but to diminish lung injury caused by virulent pneumonia.
Lead Product(s):
Recombinant human plasma gelsolin
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