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II","country":"","productType":"Peptide","productStatus":"New Molecular Entity","date":"July 2023","year":"2023","type":"Public Offering","leadProduct":"BT5528","moa":"","url1":"","url2":"","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"Bicycle Therapeutics","amount2":0.23000000000000001,"therapeuticAreaNew":"Oncology","highestDevelopmentStatusNew":"Phase I\/ Phase II","highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","productSubType":"","amount2New":0.23000000000000001,"dosageForm":"Infusion","sponsorNew":"Bicycle Therapeutics \/ Goldman Sachs & Co.","highestDevelopmentStatusID":"7","companyTruncated":"Bicycle Th.."},{"orgOrder":0,"company":"Bicycle Therapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","amount":"Not Applicable","upfrontCash":"Not Applicable","newsHeadline":"Bicycle Therapeutics Announces Expedited Development Plan for BT8009 in Metastatic Bladder Cancer","therapeuticArea":"Oncology","highestDevelopmentStatus":"Phase I\/ Phase II","country":"","productType":"Peptide","productStatus":"New Molecular Entity","date":"September 2023","year":"2023","type":"Not Applicable","leadProduct":"BT8009","moa":"","url1":"","url2":"","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"Bicycle Therapeutics","amount2":0,"therapeuticAreaNew":"Oncology","highestDevelopmentStatusNew":"Phase I\/ Phase II","highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","productSubType":"","amount2New":0,"dosageForm":"Infusion","sponsorNew":"Bicycle Therapeutics \/ Not Applicable","highestDevelopmentStatusID":"7","companyTruncated":"Bicycle Th.."},{"orgOrder":0,"company":"Bicycle Therapeutics","sponsor":"Deep Track Capital","pharmaFlowCategory":"D","amount":"$555.0 million","upfrontCash":"Undisclosed","newsHeadline":"Bicycle Therapeutics Announces $555 Million Private Placement Equity Financing","therapeuticArea":"Oncology","highestDevelopmentStatus":"Phase II\/ Phase III","country":"","productType":"Peptide","productStatus":"New Molecular Entity","date":"May 2024","year":"2024","type":"Private Placement","leadProduct":"Pembrolizumab","moa":"","url1":"","url2":"","graph1":"Oncology","graph2":"Phase II\/ Phase III","graph3":"Bicycle Therapeutics","amount2":0.56000000000000005,"therapeuticAreaNew":"Oncology","highestDevelopmentStatusNew":"Phase II\/ Phase III","highestDevelopmentShortName":"Ph II\/III","therapeuticAreaShortName":"Oncology","productSubType":"","amount2New":0.56000000000000005,"dosageForm":"Infusion","sponsorNew":"Bicycle Therapeutics \/ Deep Track Capital","highestDevelopmentStatusID":"9","companyTruncated":"Bicycle Th.."}]

Find Clinical Drug Pipeline Developments & Deals by Bicycle Therapeutics

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                          Therapeutic Area by Lead Product

                          Study Phase by Lead Product

                          Company by Lead Product

                          Top Deals by Deal Size (USD bn)

                          01

                          Boulder Peptide 2024
                          Not Confirmed
                          Boulder Peptide 2024
                          Not Confirmed

                          Lead Product(s) : Zelenectide Pevedotin,Pembrolizumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II/ Phase III

                          Partner/Sponsor/Collaborator : Deep Track Capital

                          Deal Size : $555.0 million

                          Deal Type : Private Placement

                          Details : Bicycle will fund the continued development of BT8009 targets Nectin-4, a cell adhesion molecule. It is being evaluated in the clinical trial studies for the treatment of metastatic urothelial cancer.

                          Product Name : BT8009

                          Product Type : Peptide

                          Upfront Cash : Undisclosed

                          May 23, 2024

                          Lead Product(s) : Zelenectide Pevedotin,Pembrolizumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II/ Phase III

                          Partner/Sponsor/Collaborator : Deep Track Capital

                          Deal Size : $555.0 million

                          Deal Type : Private Placement

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                          02

                          Boulder Peptide 2024
                          Not Confirmed
                          Boulder Peptide 2024
                          Not Confirmed

                          Details : BT8009 is an investigational Bicycle Toxin Conjugate (BTC™) targeting Nectin-4, a well-validated tumor antigen with elevated levels of expression in multiple tumor types, including bladder (urothelial) ...

                          Product Name : BT8009

                          Product Type : Peptide

                          Upfront Cash : Not Applicable

                          September 11, 2023

                          Lead Product(s) : BT8009,Pembrolizumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Partner/Sponsor/Collaborator : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          03

                          Boulder Peptide 2024
                          Not Confirmed
                          Boulder Peptide 2024
                          Not Confirmed

                          Lead Product(s) : BT5528,Nivolumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Partner/Sponsor/Collaborator : Goldman Sachs & Co.

                          Deal Size : $230.0 million

                          Deal Type : Public Offering

                          Details : The net proceeds will be used for the development of BT5528, a second-generation Bicycle Toxin Conjugate (BTC®) targeting EphA2, in patients with advanced solid tumors.

                          Product Name : BT5528

                          Product Type : Peptide

                          Upfront Cash : Undisclosed

                          July 18, 2023

                          Lead Product(s) : BT5528,Nivolumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Partner/Sponsor/Collaborator : Goldman Sachs & Co.

                          Deal Size : $230.0 million

                          Deal Type : Public Offering

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                          04

                          Boulder Peptide 2024
                          Not Confirmed
                          Boulder Peptide 2024
                          Not Confirmed

                          Details : Bicycle plans to use the net proceeds from the offering to fund the continued development of its proprietary pipeline including, BT8009, a Nectin-4 targeting Bicycle Toxin Conjugate, being developed for t...

                          Product Name : BT8009

                          Product Type : Peptide

                          Upfront Cash : Undisclosed

                          July 12, 2023

                          Lead Product(s) : BT8009,Pembrolizumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Partner/Sponsor/Collaborator : Goldman Sachs & Co.

                          Deal Size : $200.0 million

                          Deal Type : Public Offering

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                          05

                          Boulder Peptide 2024
                          Not Confirmed
                          Boulder Peptide 2024
                          Not Confirmed

                          Lead Product(s) : Bicyclic Peptide-based Radio Conjugate

                          Therapeutic Area : Oncology

                          Highest Development Status : Discovery

                          Partner/Sponsor/Collaborator : Bayer AG

                          Deal Size : $1,745.0 million

                          Deal Type : Collaboration

                          Details : The collaboration will leverage Bicycle Therapeutic’s proprietary bicyclic peptides technology (Bicycle®), for the discovery and development, manufacture, and commercialize Bicycle radioconjugates for ...

                          Product Name : Undislcosed

                          Product Type : Peptide

                          Upfront Cash : $45.0 million

                          May 10, 2023

                          Lead Product(s) : Bicyclic Peptide-based Radio Conjugate

                          Therapeutic Area : Oncology

                          Highest Development Status : Discovery

                          Partner/Sponsor/Collaborator : Bayer AG

                          Deal Size : $1,745.0 million

                          Deal Type : Collaboration

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                          06

                          Boulder Peptide 2024
                          Not Confirmed
                          Boulder Peptide 2024
                          Not Confirmed

                          Lead Product(s) : Bicyclic Peptide-based Radio Conjugate

                          Therapeutic Area : Oncology

                          Highest Development Status : Discovery

                          Partner/Sponsor/Collaborator : German Cancer Research Center

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

                          Details : Under the terms of the collaboration, Bicycle Therapeutics and German Cancer Research Center will develop and discover Bicycle® radio conjugates (BRCs) for a range of oncology targets.

                          Product Name : Undisclosed

                          Product Type : Peptide

                          Upfront Cash : Undisclosed

                          May 04, 2023

                          Lead Product(s) : Bicyclic Peptide-based Radio Conjugate

                          Therapeutic Area : Oncology

                          Highest Development Status : Discovery

                          Partner/Sponsor/Collaborator : German Cancer Research Center

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

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                          07

                          Boulder Peptide 2024
                          Not Confirmed
                          Boulder Peptide 2024
                          Not Confirmed

                          Details : Bicycle and Novartis will collaborate on the discovery and development of Bicycle® radio-conjugates (BRCs) for multiple targeted radioligand therapies in oncology using Bicycle's proprietary bicyclic pep...

                          Product Name : Undisclosed

                          Product Type : Peptide

                          Upfront Cash : $50.0 million

                          March 28, 2023

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Oncology

                          Highest Development Status : Discovery

                          Partner/Sponsor/Collaborator : Novartis Pharmaceuticals Corporation

                          Deal Size : $1,750.0 million

                          Deal Type : Collaboration

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                          08

                          Boulder Peptide 2024
                          Not Confirmed
                          Boulder Peptide 2024
                          Not Confirmed

                          Details : BT8009 is a monotherapy which targets Nectin-4, a cell adhesion molecule from the Nectin and Nectin-like family, which has been shown to be overexpressed in tumor cells and is believed to play a role in t...

                          Product Name : BT8009

                          Product Type : Large molecule

                          Upfront Cash : Not Applicable

                          February 14, 2023

                          Lead Product(s) : BT8009,Pembrolizumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Partner/Sponsor/Collaborator : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          09

                          Boulder Peptide 2024
                          Not Confirmed
                          Boulder Peptide 2024
                          Not Confirmed

                          Details : BT8009 is a monotherapy which targets Nectin-4, a cell adhesion molecule from the Nectin and Nectin-like family, which has been shown to be overexpressed in tumor cells and is believed to play a role in t...

                          Product Name : BT8009

                          Product Type : Large molecule

                          Upfront Cash : Not Applicable

                          January 11, 2023

                          Lead Product(s) : BT8009,Pembrolizumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Partner/Sponsor/Collaborator : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          10

                          Boulder Peptide 2024
                          Not Confirmed
                          Boulder Peptide 2024
                          Not Confirmed

                          Details : BT8009 (Bicyclic Peptide) is a monotherapy for the treatment of adult patients with previously treated locally advanced or metastatic urothelial cancer. BT8009, targets Nectin-4 protein that is over expre...

                          Product Name : BT8009

                          Product Type : Large molecule

                          Upfront Cash : Not Applicable

                          January 04, 2023

                          Lead Product(s) : BT8009,Pembrolizumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Partner/Sponsor/Collaborator : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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