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Biosciences","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Miscellaneous","year":"2022","type":"Inapplicable","leadProduct":"Bezuclastinib","moa":"||KIT*","graph1":"Oncology","graph2":"Phase III","graph3":"Cogent Biosciences","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Tablet","sponsorNew":"Cogent Biosciences \/ Undisclosed","highestDevelopmentStatusID":"10","companyTruncated":"Cogent Biosciences \/ Undisclosed"},{"orgOrder":0,"company":"Cogent Biosciences","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Miscellaneous","year":"2024","type":"Inapplicable","leadProduct":"Bezuclastinib","moa":"||KIT*","graph1":"Oncology","graph2":"Phase III","graph3":"Cogent Biosciences","amount2":0,"highestDevelopmentShortName":"Ph 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Find Clinical Drug Pipeline Developments & Deals for Bezuclastinib

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                          Top Deals by Deal Size (USD bn)

                          01

                          FNCE
                          Not Confirmed
                          FNCE
                          Not Confirmed

                          Details : The net proceeds will be used to accelerate our CGT9486 (bezuclastinib), a selective tyrosine kinase inhibitor selectively targeting KIT activation loop mutations in systemic mastocytosis, launch.

                          Product Name : Undisclosed

                          Product Type : Miscellaneous

                          Upfront Cash : Undisclosed

                          July 10, 2025

                          Lead Product(s) : Bezuclastinib,Sunitinib

                          Therapeutic Area : Hematology

                          Highest Development Status : Phase III

                          Sponsor : J.P. Morgan

                          Deal Size : $230.0 million

                          Deal Type : Public Offering

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                          02

                          FNCE
                          Not Confirmed
                          FNCE
                          Not Confirmed

                          Details : The net proceeds will be used to accelerate our CGT9486 (bezuclastinib), a selective tyrosine kinase inhibitor selectively targeting KIT activation loop mutations in systemic mastocytosis, launch.

                          Product Name : Undisclosed

                          Product Type : Miscellaneous

                          Upfront Cash : Undisclosed

                          July 08, 2025

                          Lead Product(s) : Bezuclastinib,Sunitinib

                          Therapeutic Area : Hematology

                          Highest Development Status : Phase III

                          Sponsor : J.P. Morgan

                          Deal Size : $150.0 million

                          Deal Type : Public Offering

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                          03

                          FNCE
                          Not Confirmed
                          FNCE
                          Not Confirmed

                          Details : The net proceeds will be used to accelerate our CGT9486 (bezuclastinib), a selective tyrosine kinase inhibitor selectively targeting KIT activation loop mutations in systemic mastocytosis, launch.

                          Product Name : Undisclosed

                          Product Type : Miscellaneous

                          Upfront Cash : Undisclosed

                          June 11, 2025

                          Lead Product(s) : Bezuclastinib,Sunitinib

                          Therapeutic Area : Hematology

                          Highest Development Status : Phase III

                          Sponsor : SLR Capital Partners

                          Deal Size : Undisclosed

                          Deal Type : Financing

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                          04

                          FNCE
                          Not Confirmed
                          FNCE
                          Not Confirmed

                          Details : Bezuclastinib is a Other Small Molecule drug candidate, which is currently being evaluated in clinical studies for the treatment of Gastrointestinal Stromal Tumors.

                          Product Name : Undisclosed

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          April 29, 2025

                          Lead Product(s) : Bezuclastinib

                          Therapeutic Area : Oncology

                          Highest Development Status : Undisclosed

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          05

                          FNCE
                          Not Confirmed
                          FNCE
                          Not Confirmed

                          Details : Bezuclastinib is a Other Small Molecule drug candidate, which is currently being evaluated in clinical studies for the treatment of Mastocytosis, Systemic.

                          Product Name : Undisclosed

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          April 08, 2025

                          Lead Product(s) : Bezuclastinib

                          Therapeutic Area : Hematology

                          Highest Development Status : Undisclosed

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          06

                          FNCE
                          Not Confirmed
                          FNCE
                          Not Confirmed

                          Details : CGT9486 (bezuclastinib) is a selective tyrosine kinase inhibitor, designed to potently inhibit the KIT D816V mutation. It is being evaluated for the treatment of nonadvanced systemic mastocytosis.

                          Product Name : Undisclosed

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          December 09, 2024

                          Lead Product(s) : Bezuclastinib

                          Therapeutic Area : Hematology

                          Highest Development Status : Phase III

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          07

                          FNCE
                          Not Confirmed
                          FNCE
                          Not Confirmed

                          Details : CGT9486 (bezuclastinib) is a selective tyrosine kinase inhibitor, designed to potently inhibit the KIT D816V mutation. It is being evaluated for the treatment of advanced systemic mastocytosis.

                          Product Name : Undisclosed

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          December 08, 2024

                          Lead Product(s) : Bezuclastinib

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          08

                          FNCE
                          Not Confirmed
                          FNCE
                          Not Confirmed

                          Details : CGT9486 (bezuclastinib), is a KIT mutant inhibitor, being investigated in combination with sunitinib for patients living with gastrointestinal stromal tumors.

                          Product Name : Undisclosed

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          September 03, 2024

                          Lead Product(s) : Bezuclastinib,Sunitinib

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          09

                          FNCE
                          Not Confirmed
                          FNCE
                          Not Confirmed

                          Details : CGT9486 (bezuclastinib) is a selective tyrosine kinase inhibitor, designed to potently inhibit the KIT D816V mutation. It is being evaluated for the treatment of nonadvanced systemic mastocytosis.

                          Product Name : Undisclosed

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          June 14, 2024

                          Lead Product(s) : Bezuclastinib

                          Therapeutic Area : Hematology

                          Highest Development Status : Phase II

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          10

                          FNCE
                          Not Confirmed
                          FNCE
                          Not Confirmed

                          Details : CGT9486 (bezuclastinib) is a selective tyrosine kinase inhibitor that is designed to potently inhibit the KIT D816V mutation. It is being evaluated for nonadvanced systemic mastocytosis.

                          Product Name : Undisclosed

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          February 22, 2024

                          Lead Product(s) : Bezuclastinib

                          Therapeutic Area : Hematology

                          Highest Development Status : Phase II

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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