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Disease","amount2New":0,"dosageForm":"Infusion","sponsorNew":"Avidity Biosciences \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"Avidity Biosciences \/ Inapplicable"},{"orgOrder":0,"company":"Avidity Biosciences","sponsor":"Adage Capital Partners","pharmaFlowCategory":"D","therapeuticArea":"Genetic Disease","country":"U.S.A","productType":"Antibody-oligonucleotide Conjugate","year":"2024","type":"Private Placement","leadProduct":"Del-Desiran","moa":"Transferrin-1 receptor","graph1":"Genetic Disease","graph2":"Phase III","graph3":"Avidity Biosciences","amount2":0.40000000000000002,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Genetic Disease","amount2New":0.40000000000000002,"dosageForm":"Infusion","sponsorNew":"Avidity Biosciences \/ Adage Capital Partners","highestDevelopmentStatusID":"10","companyTruncated":"Avidity Biosciences \/ Adage Capital Partners"},{"orgOrder":0,"company":"Avidity 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Biosciences","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Genetic Disease","country":"U.S.A","productType":"Antibody-oligonucleotide Conjugate","year":"2023","type":"Inapplicable","leadProduct":"Del-Desiran","moa":"Transferrin-1 receptor","graph1":"Genetic Disease","graph2":"Phase III","graph3":"Avidity Biosciences","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Genetic Disease","amount2New":0,"dosageForm":"Infusion","sponsorNew":"Avidity Biosciences \/ Inapplicable","highestDevelopmentStatusID":"10","companyTruncated":"Avidity Biosciences \/ Inapplicable"},{"orgOrder":0,"company":"Avidity Biosciences","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Genetic Disease","country":"U.S.A","productType":"Antibody-oligonucleotide Conjugate","year":"2022","type":"Inapplicable","leadProduct":"Del-Desiran","moa":"Transferrin-1 receptor","graph1":"Genetic Disease","graph2":"Phase III","graph3":"Avidity Biosciences","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Genetic Disease","amount2New":0,"dosageForm":"Infusion","sponsorNew":"Avidity Biosciences \/ Inapplicable","highestDevelopmentStatusID":"10","companyTruncated":"Avidity Biosciences \/ Inapplicable"},{"orgOrder":0,"company":"Avidity Biosciences","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Genetic Disease","country":"U.S.A","productType":"Antibody-drug Conjugate","year":"2024","type":"Inapplicable","leadProduct":"Delpacibart Etedesiran","moa":"Undisclosed","graph1":"Genetic Disease","graph2":"Phase III","graph3":"Avidity Biosciences","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Genetic Disease","amount2New":0,"dosageForm":"Infusion","sponsorNew":"Avidity Biosciences \/ Inapplicable","highestDevelopmentStatusID":"10","companyTruncated":"Avidity Biosciences \/ Inapplicable"},{"orgOrder":0,"company":"Avidity 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                          Top Deals by Deal Size (USD bn)

                          01

                          Boulder Peptide
                          Not Confirmed
                          Boulder Peptide
                          Not Confirmed

                          Details : AOC-1020 is a Antibody drug candidate, which is currently being evaluated in Phase III clinical studies for the treatment of Muscular Dystrophy, Facioscapulohumeral.

                          Product Name : Undisclosed

                          Product Type : Antibody

                          Upfront Cash : Inapplicable

                          June 26, 2025

                          Lead Product(s) : AOC-1020

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : Phase III

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          02

                          Boulder Peptide
                          Not Confirmed
                          Boulder Peptide
                          Not Confirmed

                          Details : Del-desiran is a Antibody-oligonucleotide Conjugate drug candidate, which is currently being evaluated in Phase III clinical studies for the treatment of Myotonic Dystrophy.

                          Product Name : Undisclosed

                          Product Type : Antibody-oligonucleotide Conjugate

                          Upfront Cash : Inapplicable

                          June 06, 2025

                          Lead Product(s) : Del-desiran

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : Phase III

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          03

                          Boulder Peptide
                          Not Confirmed
                          Boulder Peptide
                          Not Confirmed

                          Details : AOC 1001 (Delpacibart Etedesiran) consists of an antibody that binds to TfR1 conjugated with a siRNA targeting DMPK mRNA. It is being evaluated for the treatment of myotonic dystrophy type 1.

                          Product Name : Del-Desiran

                          Product Type : Antibody-drug Conjugate

                          Upfront Cash : Inapplicable

                          April 08, 2025

                          Lead Product(s) : Delpacibart Etedesiran

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          04

                          Boulder Peptide
                          Not Confirmed
                          Boulder Peptide
                          Not Confirmed

                          Details : AOC 1044 (delpacibart zotadirsen) is designed to deliver phosphorodiamidate morpholino oligomers. It is being evaluated for DMD in people with mutations amenable to exon 44 skipping.

                          Product Name : Undisclosed

                          Product Type : Antibody-oligonucleotide Conjugate

                          Upfront Cash : Inapplicable

                          January 08, 2025

                          Lead Product(s) : Delpacibart Zotadirsen

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          05

                          Boulder Peptide
                          Not Confirmed
                          Boulder Peptide
                          Not Confirmed

                          Details : AOC 1086 is designed to deliver siRNA directly to the heart muscle to knock down specific disease-causing genetic mutations that cause rare genetic PLN cardiomyopathies.

                          Product Name : Undisclosed

                          Product Type : Other Large Molecule

                          Upfront Cash : Inapplicable

                          December 11, 2024

                          Lead Product(s) : AOC 1086

                          Therapeutic Area : Cardiology/Vascular Diseases

                          Highest Development Status : Preclinical

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          06

                          Boulder Peptide
                          Not Confirmed
                          Boulder Peptide
                          Not Confirmed

                          Details : The net proceeds to fund research and development of its clinical-stage product Del-desiran (delpacibart etedesiran), designed to reduce DMPK mRNA levels for treating myotonic dystrophy type 1.

                          Product Name : Del-Desiran

                          Product Type : Antibody-drug Conjugate

                          Upfront Cash : Undisclosed

                          December 06, 2024

                          Lead Product(s) : Delpacibart Etedesiran

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : Phase III

                          Sponsor : TD Cowen

                          Deal Size : $345.0 million

                          Deal Type : Public Offering

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                          07

                          Boulder Peptide
                          Not Confirmed
                          Boulder Peptide
                          Not Confirmed

                          Details : AOC 1020 (delpacibart braxlosiran) is an AOC comprised of a DUX4-targeting siRNA conjugated to a humanized antibody targeting transferrin receptor 1 to facilitate delivery to muscle.

                          Product Name : Undisclosed

                          Product Type : Antibody-oligonucleotide Conjugate

                          Upfront Cash : Inapplicable

                          October 30, 2024

                          Lead Product(s) : Delpacibart Braxlosiran

                          Therapeutic Area : Musculoskeletal

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          08

                          Boulder Peptide
                          Not Confirmed
                          Boulder Peptide
                          Not Confirmed

                          Details : AOC 1044 is designed to deliver phosphorodiamidate morpholino oligomers. It is being evaluated for duchenne muscular dystrophy in people with mutations amenable to exon 44 skipping.

                          Product Name : Undisclosed

                          Product Type : Antibody-oligonucleotide Conjugate

                          Upfront Cash : Inapplicable

                          September 08, 2024

                          Lead Product(s) : Delpacibart Zotadirsen

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          09

                          Boulder Peptide
                          Not Confirmed
                          Boulder Peptide
                          Not Confirmed

                          Details : Avidity will fund the development of its clinical programs and advance research and development associated with its AOC platform, including AOC 1001 (delpacibart etedesiran) for DMD.

                          Product Name : Del-Desiran

                          Product Type : Antibody-drug Conjugate

                          Upfront Cash : Undisclosed

                          August 19, 2024

                          Lead Product(s) : Delpacibart Etedesiran

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : Phase III

                          Sponsor : Leerink Partners

                          Deal Size : $345.1 million

                          Deal Type : Public Offering

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                          10

                          Boulder Peptide
                          Not Confirmed
                          Boulder Peptide
                          Not Confirmed

                          Details : Avidity will fund the development of its clinical programs and advance research and development associated with its AOC platform, including AOC 1001 (delpacibart etedesiran) for DMD.

                          Product Name : Del-Desiran

                          Product Type : Antibody-drug Conjugate

                          Upfront Cash : Undisclosed

                          August 13, 2024

                          Lead Product(s) : Delpacibart Etedesiran

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : Phase III

                          Sponsor : Leerink Partners

                          Deal Size : $250.0 million

                          Deal Type : Public Offering

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