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Find Clinical Drug Pipeline Developments & Deals by Aveo Oncology
FOTIVDA (tivozanib) is an oral, next-generation vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitor, which is investigated in Combination with OPDIVO® (nivolumab) in Advanced Renal Cell Carcinoma.
AVEO will establish LG Chem’s commercial presence in oncology through AVEO’s lead product, FOTIVDA® (tivozanib), which received U.S. FDA approval for the treatment of relapsed or refractory advanced renal cell carcinoma following two or more prior systemic therapies.
FOTIVDA® (tivozanib) is an oral, next-generation vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitor (TKI). It is a potent, selective inhibitor of VEGFRs 1, 2, and 3 with a long half-life designed to improve efficacy and tolerability.
Under the terms of the agreement, Lilly will provide cetuximab clinical drug supply in the U.S. and Canada for AVEO’s potential registrational study, which will assess AV-299 (ficlatuzumab) with cetuximab in HPV negative R/M HNSCC.
Exploratory long-term OS analyses of TIVO-3 continue to trend in favor of Fotivda (tivozanib), patients with PFS at 1 year demonstrated a 55% reduction in risk of death on tivozanib as compared to sorafenib.
Actinium to apply its proprietary Antibody Warhead Enabling (AWE) technology platform to perform conjugation of AVEO's ErbB3 targeted antibody with Actinium-225, a potent alpha-emitting radioisotope, to form a novel Ac-225 ErbB3 targeted radiotherapy.
Five year follow-up data show FOTIVDA® (tivozanib), next-generation vascular endothelial growth factor receptor tyrosine kinase inhibitor patients up to 5X more likely to experience long-term PFS compared to Nexavar.
First-line cohort of the Phase 1b/2 DEDUCTIVE study demonstrates promising efficacy and tolerability of Fotivda (tivozanib) plus Imfinzi (durvalumab) in first-line HCC.
The collaboration with NiKang, will play an important role in the advancement of both tivozanib and NKT2152 program. Under the terms of the agreement, NiKang will sponsor the trial and AVEO will co-fund the trial. Both companies will provide its respective drugs at no cost.
The net proceeds of the offering are used to support commercialization activities relating to Fotivda (tivozanib) and to advance AVEO’s pipeline. Fotivda is the first and only approved treatment specifically for advanced kidney cancer or renal cell carcinoma.
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