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    [{"orgOrder":0,"company":"Avalo Therapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","amount":"Not Applicable","upfrontCash":"Not Applicable","newsHeadline":"Avalo Reports Positive Phase 1b Results for AVTX-002 in Moderate to Severe Crohn's Disease Patients and Presents Additional Program Updates at 2022 Investor Event","therapeuticArea":"Gastroenterology","highestDevelopmentStatus":"Phase I","country":"U.S.A","productType":"Large molecule","productStatus":"New Molecular Entity","date":"January 2022","url1":"","url2":"","graph1":"Gastroenterology","graph2":"Phase I"},{"orgOrder":0,"company":"Avalo Therapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","amount":"Not Applicable","upfrontCash":"Not Applicable","newsHeadline":"Avalo Therapeutics Announces First Patient Dosed in the Phase 2 PEAK Trial of AVTX-002 for the Treatment of Non-Eosinophilic Asthma (NEA)","therapeuticArea":"Pulmonary\/Respiratory Diseases","highestDevelopmentStatus":"Phase II","country":"U.S.A","productType":"Large molecule","productStatus":"New Molecular Entity","date":"May 2022","url1":"","url2":"","graph1":"Pulmonary\/Respiratory Diseases","graph2":"Phase II"},{"orgOrder":0,"company":"Avalo Therapeutics","sponsor":"Apollo Therapeutics","pharmaFlowCategory":"D","amount":"$89.0 million","upfrontCash":"$15.0 million","newsHeadline":"Avalo Therapeutics Transfers Anti-IL-18 Antibody, AVTX-007 (camoteskimab) to Apollo Therapeutics","therapeuticArea":"Pulmonary\/Respiratory Diseases","highestDevelopmentStatus":"Phase II","country":"U.S.A","productType":"Large molecule","productStatus":"New Molecular Entity","date":"August 2022","url1":"","url2":"","graph1":"Pulmonary\/Respiratory Diseases","graph2":"Phase II"},{"orgOrder":0,"company":"Avalo Therapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","amount":"Not Applicable","upfrontCash":"Not Applicable","newsHeadline":"Avalo Therapeutics Announces First Patient Dosed in the AVTX-803 Pivotal Trial (LADDER) for the Treatment of Leukocyte Adhesion Deficiency Type II (LAD II)","therapeuticArea":"Genetic Disease","highestDevelopmentStatus":"Phase III","country":"U.S.A","productType":"Small molecule","productStatus":"New Molecular Entity","date":"August 2022","url1":"","url2":"","graph1":"Genetic Disease","graph2":"Phase III"},{"orgOrder":0,"company":"Avalo Therapeutics","sponsor":"ES Therapeutics","pharmaFlowCategory":"D","amount":"$5.0 million","upfrontCash":"Undisclosed","newsHeadline":"Avalo Sells Economic Rights to Previously Out-Licensed Assets for $5 Million","therapeuticArea":"Pulmonary\/Respiratory Diseases","highestDevelopmentStatus":"Phase II","country":"U.S.A","productType":"Large molecule","productStatus":"New Molecular Entity","date":"November 2022","url1":"","url2":"","graph1":"Pulmonary\/Respiratory Diseases","graph2":"Phase II"},{"orgOrder":0,"company":"Avalo Therapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","amount":"Not Applicable","upfrontCash":"Not Applicable","newsHeadline":"Avalo Announces it Has Completed Targeted Enrollment of 80 Patients in Phase 2 PEAK Trial of AVTX-002 in Non-Eosinophilic Asthma","therapeuticArea":"Pulmonary\/Respiratory Diseases","highestDevelopmentStatus":"Phase II","country":"U.S.A","productType":"Large molecule","productStatus":"New Molecular Entity","date":"January 2023","url1":"","url2":"","graph1":"Pulmonary\/Respiratory Diseases","graph2":"Phase II"},{"orgOrder":0,"company":"Avalo Therapeutics","sponsor":"SVB Securities","pharmaFlowCategory":"D","amount":"$15.0 million","upfrontCash":"Undisclosed","newsHeadline":"Avalo Therapeutics, Inc. 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              Avalo Therapeutics

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              Avalo Acquires Anti-IL-1β mAb and Announces Private Placement Financing of up to $185 Million

              Details:

              Through the acquisition of AlmataBio, Avalo acquires Phase 2-ready, AVTX-009, a humanized monoclonal antibody (IgG4) that binds to interleukin-1β, being developed for hidradenitis suppurativa.

              Lead Product(s): AVTX-009

              Therapeutic Area: Dermatology Product Name: AVTX-009

              Highest Development Status: Phase I Product Type: Large molecule

              Recipient: AlmataBio

              Deal Size: Undisclosed Upfront Cash: Undisclosed

              Deal Type: Acquisition March 27, 2024

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              Avalo Therapeutics

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              Avalo Acquires Anti-IL-1β mAb and Announces Private Placement Financing of up to $185 Million

              Details:

              The net proceeds will be used for the developement of AVTX-009, a humanized monoclonal antibody (IgG4) that binds to interleukin-1β, being developed for hidradenitis suppurativa.

              Lead Product(s): AVTX-009

              Therapeutic Area: Dermatology Product Name: AVTX-009

              Highest Development Status: Phase I Product Type: Large molecule

              Partner/Sponsor/Collaborator: Commodore Capital

              Deal Size: $185.0 million Upfront Cash: $115.6 million

              Deal Type: Private Placement March 27, 2024

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              Avalo Therapeutics

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              Avalo Enters into Agreement to Divest AVTX-800 Series

              Details:

              Under the divestiture, AUG gains rights, title and interest in, assets relating to AVTX-801 (D-galactose), AVTX-802 (D-mannose) and AVTX-803 (L-fucose). AVTX-801 is a therapeutic dose of D-galactose currently in development for the treatment of phosphoglucomutase 1 deficiency.

              Lead Product(s): Alpha-D-Galactose

              Therapeutic Area: Genetic Disease Product Name: AVTX-801

              Highest Development Status: Phase II Product Type: Small molecule

              Partner/Sponsor/Collaborator: AUG Therapeutics

              Deal Size: $45.1 million Upfront Cash: $0.1 million

              Deal Type: Divestment September 12, 2023

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              Avalo Therapeutics

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              Avalo Announces Topline Data from Phase 2 PEAK Trial for AVTX-002 (quisovalimab) in Patients with Non-Eosinophilic Asthma

              Details:

              AVTX-002 (quisovalimab) is a fully human monoclonal antibody (mAb), directed against human LIGHT, and investigated for the treatment of patients with poorly controlled non-eosinophilic asthma

              Lead Product(s): Quisovalimab

              Therapeutic Area: Pulmonary/Respiratory Diseases Product Name: AVTX-002

              Highest Development Status: Phase II Product Type: Large molecule

              Partner/Sponsor/Collaborator: Not Applicable

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable June 26, 2023

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              Avalo Therapeutics

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              Avalo Therapeutics, Inc. Announces Pricing of $15 Million Public Offering of Common Stock and Warrants

              Details:

              AVTX-002 is a fully human monoclonal antibody, directed against human LIGHT. AVTX-002 is currently in Phase 2 development for non-eosinophilic asthma (NEA) with proof-of-concept data in inflammatory bowel diseases (IBD) and COVID-19 acute respiratory distress syndrome (ARDS).

              Lead Product(s): AVTX-002

              Therapeutic Area: Pulmonary/Respiratory Diseases Product Name: AVTX-002

              Highest Development Status: Phase II Product Type: Large molecule

              Partner/Sponsor/Collaborator: SVB Securities

              Deal Size: $15.0 million Upfront Cash: Undisclosed

              Deal Type: Public Offering February 02, 2023

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              Avalo Therapeutics

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              Avalo Announces it Has Completed Targeted Enrollment of 80 Patients in Phase 2 PEAK Trial of AVTX-002 in Non-Eosinophilic Asthma

              Details:

              AVTX-002 is a fully human monoclonal antibody (mAb), directed against human LIGHT (Lymphotoxin-like, exhibits Inducible expression, and competes with Herpes Virus Glycoprotein D for Herpesvirus Entry Mediator (HVEM), a receptor expressed by T lymphocytes).

              Lead Product(s): Monoclonal Antibody

              Therapeutic Area: Pulmonary/Respiratory Diseases Product Name: AVTX-002

              Highest Development Status: Phase II Product Type: Large molecule

              Partner/Sponsor/Collaborator: Not Applicable

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable January 17, 2023

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              Avalo Therapeutics

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              Avalo Sells Economic Rights to Previously Out-Licensed Assets for $5 Million

              Details:

              AVTX-007 is a fully human monoclonal antibody for the treatment of Still’s Disease, including adult-onset Still’s disease (AOSD) and systemic juvenile jdiopathic Arthritis (SJIA).

              Lead Product(s): AVTX-007

              Therapeutic Area: Pulmonary/Respiratory Diseases Product Name: AVTX-007

              Highest Development Status: Phase II Product Type: Large molecule

              Partner/Sponsor/Collaborator: ES Therapeutics

              Deal Size: $5.0 million Upfront Cash: Undisclosed

              Deal Type: Agreement November 07, 2022

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              Avalo Therapeutics

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              Avalo Therapeutics Announces First Patient Dosed in the AVTX-803 Pivotal Trial (LADDER) for the Treatment of Leukocyte Adhesion Deficiency Type II (LAD II)

              Details:

              The active pharmaceutical ingredient (API) in AVTX-803 is L-fucose an oral formulation of L-fucose that enhances fucosylation of proteins in the absence of a functioning GDP-fucose transporter, partially restoring protein function.

              Lead Product(s): L-Fucose

              Therapeutic Area: Genetic Disease Product Name: AVTX-803

              Highest Development Status: Phase III Product Type: Small molecule

              Partner/Sponsor/Collaborator: Not Applicable

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable August 02, 2022

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              Avalo Therapeutics Transfers Anti-IL-18 Antibody, AVTX-007 (camoteskimab) to Apollo Therapeutics

              Details:

              Under the terms of the agreement, Apollo will assume responsibility for the future development of AVTX-007 (camoteskimab), including the ongoing clinical trial. Apollo will lead future clinical development in its selected therapeutic indications.

              Lead Product(s): AVTX-002

              Therapeutic Area: Pulmonary/Respiratory Diseases Product Name: AVTX-002

              Highest Development Status: Phase II Product Type: Large molecule

              Partner/Sponsor/Collaborator: Apollo Therapeutics

              Deal Size: $89.0 million Upfront Cash: $15.0 million

              Deal Type: Licensing Agreement August 01, 2022

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              Avalo Therapeutics Announces First Patient Dosed in the Phase 2 PEAK Trial of AVTX-002 for the Treatment of Non-Eosinophilic Asthma (NEA)

              Details:

              MDGN-002 (AVTX-002) is a fully human anti-LIGHT, monoclonal antibody in development for the treatment of acute respiratory distress syndrome (ARDS), the treatment of inflammatory bowel disease (IBD) and the treatment of non-eosinophilic asthma.

              Lead Product(s): AVTX-002

              Therapeutic Area: Pulmonary/Respiratory Diseases Product Name: MDGN-002

              Highest Development Status: Phase II Product Type: Large molecule

              Partner/Sponsor/Collaborator: Not Applicable

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable May 18, 2022

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