Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target
Lead Product(s) : Avacopan,Rituximab
Therapeutic Area : Immunology
Study Phase : Approved FDF
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Tavneos® (avacopan) Approved In Australia For the Treatment Of ANCA-Associated Vasculitis
Details : Tavneos (avacopan) is a complement 5a receptor (C5aR) antagonist that inhibits the interaction between C5aR and the anaphylatoxin C5a, blocking neutrophil activation and migration. Currently being developed for the treatment of ANCA-associated vasculitis...
Product Name : Tavneos
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
July 02, 2023
Lead Product(s) : Avacopan,Rituximab
Therapeutic Area : Immunology
Highest Development Status : Approved FDF
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Avacopan,Rituximab
Therapeutic Area : Rare Diseases and Disorders
Study Phase : Approved FDF
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Tavneos® (avacopan) Included in Updated EULAR Recommendations for The Management Of AAV
Details : Tavneos (avacopan) is a complement 5a receptor (C5aR) antagonist that inhibits the interaction between C5aR and the anaphylatoxin C5a, blocking neutrophil activation and migration. Currently being developed for the treatment of ANCA-associated vasculitis...
Product Name : Tavneos
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
March 28, 2023
Lead Product(s) : Avacopan,Rituximab
Therapeutic Area : Rare Diseases and Disorders
Highest Development Status : Approved FDF
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Avacopan,Rituximab
Therapeutic Area : Immunology
Study Phase : Approved FDF
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : Tavneos (avacopan), approved by FDA as an adjunctive treatment of ANCA-associated vasculitis, is a first-in-class, orally administered small molecule that employs a novel, highly targeted mode of action in complement-driven autoimmune and inflammatory di...
Product Name : Tavneos
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
November 05, 2022
Lead Product(s) : Avacopan,Rituximab
Therapeutic Area : Immunology
Highest Development Status : Approved FDF
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Avacopan,Rituximab
Therapeutic Area : Immunology
Study Phase : Approved FDF
Sponsor : Amgen Inc
Deal Size : $3,700.0 million
Deal Type : Acquisition
Amgen Successfully Completes Acquisition of Chemocentryx
Details : The acquisition includes TAVNEOS (avacopan), an orally administered selective complement 5a receptor inhibitor that was approved by the U.S. FDA in October 2021 as an adjunctive therapy for adults with severe active ANCA-associated vasculitis.
Product Name : Tavneos
Product Type : Other Small Molecule
Upfront Cash : $3,700.0 million
October 20, 2022
Lead Product(s) : Avacopan,Rituximab
Therapeutic Area : Immunology
Highest Development Status : Approved FDF
Sponsor : Amgen Inc
Deal Size : $3,700.0 million
Deal Type : Acquisition
Lead Product(s) : Avacopan,Rituximab
Therapeutic Area : Immunology
Study Phase : Approved FDF
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
ChemoCentryx Announces TAVNEOS® (avacopan) Presentations at Upcoming Medical Conferences
Details : TAVNEOS® (avacopan) is indicated as adjunctive treatment of adult patients with severe active ANCA-associated vasculitis (granulomatosis with polyangiitis) and microscopic polyangiitis [MPA] in combination with standard therapy including glucocorticoids...
Product Name : Tavneos
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
August 24, 2022
Lead Product(s) : Avacopan,Rituximab
Therapeutic Area : Immunology
Highest Development Status : Approved FDF
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Avacopan,Cyclophosphamide,Rituximab
Therapeutic Area : Immunology
Study Phase : Approved FDF
Sponsor : ChemoCentryx
Deal Size : Inapplicable
Deal Type : Inapplicable
Tavneos® (avacopan) Recommended by England’s NICE for the Treatment of AAV (GPA/MPA)
Details : Tavneos® (avacopan) is an orally administered small molecule that is a selective inhibitor of the complement C5a receptor C5aR1,reduces the ability of those cells to do damage in response to C5a activation.
Product Name : Tavneos
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
August 18, 2022
Lead Product(s) : Avacopan,Cyclophosphamide,Rituximab
Therapeutic Area : Immunology
Highest Development Status : Approved FDF
Sponsor : ChemoCentryx
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Avacopan,Rituximab
Therapeutic Area : Immunology
Study Phase : Approved FDF
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
ChemoCentryx Announces Abstracts at June Rheumatology, Oncology and Nephrology Conferences
Details : TAVNEOS® (avacopan), an orally administered selective complement 5a receptor inhibitor, and have potential application in C3 glomerulopathy, as well as the immuno-oncology potential of CCX559, an orally administered small molecule PD-L1 inhibitor.
Product Name : Tavneos
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
May 31, 2022
Lead Product(s) : Avacopan,Rituximab
Therapeutic Area : Immunology
Highest Development Status : Approved FDF
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Avacopan
Therapeutic Area : Dermatology
Study Phase : Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : The findings support the Company’s plans to advance TAVNEOS® (avacopan) into Phase III development for the treatment of patients with Hurley Stage III (severe) hidradenitis suppurativa.
Product Name : Tavneos
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
May 18, 2022
Lead Product(s) : Avacopan
Therapeutic Area : Dermatology
Highest Development Status : Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Avacopan,Rituximab
Therapeutic Area : Immunology
Study Phase : Approved FDF
Sponsor : Amgen Inc
Deal Size : $3,700.0 million
Deal Type : Acquisition
Amgen to Acquire Chemocentryx for $4 Billion in Cash
Details : The acquisition of ChemoCentryx represents a compelling opportunity for Amgen to add long leadership in inflammation and nephrology with TAVNEOS (avacopan), a first-in-class medicine for patients with serious autoimmune disease, preferably ANCA-associate...
Product Name : Tavneos
Product Type : Other Small Molecule
Upfront Cash : $3,700.0 million
April 08, 2022
Lead Product(s) : Avacopan,Rituximab
Therapeutic Area : Immunology
Highest Development Status : Approved FDF
Sponsor : Amgen Inc
Deal Size : $3,700.0 million
Deal Type : Acquisition
Lead Product(s) : Avacopan,Rituximab
Therapeutic Area : Immunology
Study Phase : Approved FDF
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
VFMCRP Receives EU Approval for Tavneos® for the Treatment of ANCA-Associated Vasculitis
Details : EU approval for Tavneos (avacopan) is based on culminating in the results from the pivotal phase-III trial ADVOCATE in 331 patients with ANCA-associated vasculitis also met its primary endpoints of disease remission at week 26 and sustained remission at ...
Product Name : Tavneos
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
January 19, 2022
Lead Product(s) : Avacopan,Rituximab
Therapeutic Area : Immunology
Highest Development Status : Approved FDF
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable