[{"orgOrder":0,"company":"Amgen Inc","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Immunology","country":"U.S.A","productType":"Other Small Molecule","year":"2022","type":"Inapplicable","leadProduct":"Avacopan","moa":"||C5a receptor","graph1":"Immunology","graph2":"Approved FDF","graph3":"Amgen Inc","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Immunology","amount2New":0,"dosageForm":"Oral Capsule","sponsorNew":"Amgen Inc \/ Inapplicable","highestDevelopmentStatusID":"15","companyTruncated":"Amgen Inc \/ Inapplicable"},{"orgOrder":0,"company":"Amgen Inc","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Immunology","country":"U.S.A","productType":"Other Small Molecule","year":"2022","type":"Inapplicable","leadProduct":"Avacopan","moa":"||C5a receptor","graph1":"Immunology","graph2":"Approved FDF","graph3":"Amgen 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Inc"},{"orgOrder":0,"company":"Amgen Inc","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Immunology","country":"U.S.A","productType":"Other Small Molecule","year":"2020","type":"Inapplicable","leadProduct":"Avacopan","moa":"||C5a receptor","graph1":"Immunology","graph2":"Approved FDF","graph3":"Amgen Inc","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Immunology","amount2New":0,"dosageForm":"Oral Capsule","sponsorNew":"Amgen Inc \/ Inapplicable","highestDevelopmentStatusID":"15","companyTruncated":"Amgen Inc \/ Inapplicable"},{"orgOrder":0,"company":"Amgen Inc","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Immunology","country":"U.S.A","productType":"Other Small Molecule","year":"2020","type":"Inapplicable","leadProduct":"Avacopan","moa":"||C5a receptor","graph1":"Immunology","graph2":"Approved FDF","graph3":"Amgen 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Inapplicable"},{"orgOrder":0,"company":"Amgen Inc","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Immunology","country":"U.S.A","productType":"Other Small Molecule","year":"2021","type":"Inapplicable","leadProduct":"Avacopan","moa":"||C5a receptor","graph1":"Immunology","graph2":"Approved FDF","graph3":"Amgen Inc","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Immunology","amount2New":0,"dosageForm":"Oral Capsule","sponsorNew":"Amgen Inc \/ Inapplicable","highestDevelopmentStatusID":"15","companyTruncated":"Amgen Inc \/ Inapplicable"},{"orgOrder":0,"company":"Amgen Inc","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Immunology","country":"U.S.A","productType":"Other Small Molecule","year":"2021","type":"Inapplicable","leadProduct":"Avacopan","moa":"||C5a receptor","graph1":"Immunology","graph2":"Approved FDF","graph3":"Amgen 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Pharma","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Rare Diseases and Disorders","country":"SWITZERLAND","productType":"Other Small Molecule","year":"2023","type":"Inapplicable","leadProduct":"Avacopan","moa":"||C5a receptor","graph1":"Rare Diseases and Disorders","graph2":"Approved FDF","graph3":"Vifor Pharma","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Rare Diseases","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Vifor Pharma \/ Inapplicable","highestDevelopmentStatusID":"15","companyTruncated":"Vifor Pharma \/ Inapplicable"},{"orgOrder":0,"company":"Amgen Inc","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Dermatology","country":"U.S.A","productType":"Other Small Molecule","year":"2022","type":"Inapplicable","leadProduct":"Avacopan","moa":"C5a receptor","graph1":"Dermatology","graph2":"Phase II","graph3":"Amgen Inc","amount2":0,"highestDevelopmentShortName":"Ph 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Find Clinical Drug Pipeline Developments & Deals for Avacopan

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                          01

                          India Med Expo
                          Not Confirmed
                          India Med Expo
                          Not Confirmed

                          Details : Tavneos (avacopan) is a complement 5a receptor (C5aR) antagonist that inhibits the interaction between C5aR and the anaphylatoxin C5a, blocking neutrophil activation and migration. Currently being developed for the treatment of ANCA-associated vasculitis...

                          Product Name : Tavneos

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          July 02, 2023

                          Lead Product(s) : Avacopan,Rituximab

                          Therapeutic Area : Immunology

                          Highest Development Status : Approved FDF

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          02

                          Vifor Pharma

                          Country arrow
                          India Med Expo
                          Not Confirmed

                          Vifor Pharma

                          Country arrow
                          India Med Expo
                          Not Confirmed

                          Details : Tavneos (avacopan) is a complement 5a receptor (C5aR) antagonist that inhibits the interaction between C5aR and the anaphylatoxin C5a, blocking neutrophil activation and migration. Currently being developed for the treatment of ANCA-associated vasculitis...

                          Product Name : Tavneos

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          March 28, 2023

                          Lead Product(s) : Avacopan,Rituximab

                          Therapeutic Area : Rare Diseases and Disorders

                          Highest Development Status : Approved FDF

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          03

                          India Med Expo
                          Not Confirmed
                          India Med Expo
                          Not Confirmed

                          Details : Tavneos (avacopan), approved by FDA as an adjunctive treatment of ANCA-associated vasculitis, is a first-in-class, orally administered small molecule that employs a novel, highly targeted mode of action in complement-driven autoimmune and inflammatory di...

                          Product Name : Tavneos

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          November 05, 2022

                          Lead Product(s) : Avacopan,Rituximab

                          Therapeutic Area : Immunology

                          Highest Development Status : Approved FDF

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          04

                          ChemoCentryx

                          Country arrow
                          India Med Expo
                          Not Confirmed

                          ChemoCentryx

                          Country arrow
                          India Med Expo
                          Not Confirmed

                          Details : The acquisition includes TAVNEOS (avacopan), an orally administered selective complement 5a receptor inhibitor that was approved by the U.S. FDA in October 2021 as an adjunctive therapy for adults with severe active ANCA-associated vasculitis.

                          Product Name : Tavneos

                          Product Type : Other Small Molecule

                          Upfront Cash : $3,700.0 million

                          October 20, 2022

                          Lead Product(s) : Avacopan,Rituximab

                          Therapeutic Area : Immunology

                          Highest Development Status : Approved FDF

                          Sponsor : Amgen Inc

                          Deal Size : $3,700.0 million

                          Deal Type : Acquisition

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                          05

                          India Med Expo
                          Not Confirmed
                          India Med Expo
                          Not Confirmed

                          Details : TAVNEOS® (avacopan) is indicated as adjunctive treatment of adult patients with severe active ANCA-associated vasculitis (granulomatosis with polyangiitis) and microscopic polyangiitis [MPA] in combination with standard therapy including glucocorticoids...

                          Product Name : Tavneos

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          August 24, 2022

                          Lead Product(s) : Avacopan,Rituximab

                          Therapeutic Area : Immunology

                          Highest Development Status : Approved FDF

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          06

                          India Med Expo
                          Not Confirmed
                          India Med Expo
                          Not Confirmed

                          Details : Tavneos® (avacopan) is an orally administered small molecule that is a selective inhibitor of the complement C5a receptor C5aR1,reduces the ability of those cells to do damage in response to C5a activation.

                          Product Name : Tavneos

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          August 18, 2022

                          Lead Product(s) : Avacopan,Cyclophosphamide,Rituximab

                          Therapeutic Area : Immunology

                          Highest Development Status : Approved FDF

                          Sponsor : ChemoCentryx

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          07

                          India Med Expo
                          Not Confirmed
                          India Med Expo
                          Not Confirmed

                          Details : TAVNEOS® (avacopan), an orally administered selective complement 5a receptor inhibitor, and have potential application in C3 glomerulopathy, as well as the immuno-oncology potential of CCX559, an orally administered small molecule PD-L1 inhibitor.

                          Product Name : Tavneos

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          May 31, 2022

                          Lead Product(s) : Avacopan,Rituximab

                          Therapeutic Area : Immunology

                          Highest Development Status : Approved FDF

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          08

                          India Med Expo
                          Not Confirmed
                          India Med Expo
                          Not Confirmed

                          Details : The findings support the Company’s plans to advance TAVNEOS® (avacopan) into Phase III development for the treatment of patients with Hurley Stage III (severe) hidradenitis suppurativa.

                          Product Name : Tavneos

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          May 18, 2022

                          Lead Product(s) : Avacopan

                          Therapeutic Area : Dermatology

                          Highest Development Status : Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          09

                          ChemoCentryx

                          Country arrow
                          India Med Expo
                          Not Confirmed

                          ChemoCentryx

                          Country arrow
                          India Med Expo
                          Not Confirmed

                          Details : The acquisition of ChemoCentryx represents a compelling opportunity for Amgen to add long leadership in inflammation and nephrology with TAVNEOS (avacopan), a first-in-class medicine for patients with serious autoimmune disease, preferably ANCA-associate...

                          Product Name : Tavneos

                          Product Type : Other Small Molecule

                          Upfront Cash : $3,700.0 million

                          April 08, 2022

                          Lead Product(s) : Avacopan,Rituximab

                          Therapeutic Area : Immunology

                          Highest Development Status : Approved FDF

                          Sponsor : Amgen Inc

                          Deal Size : $3,700.0 million

                          Deal Type : Acquisition

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                          10

                          India Med Expo
                          Not Confirmed
                          India Med Expo
                          Not Confirmed

                          Details : EU approval for Tavneos (avacopan) is based on culminating in the results from the pivotal phase-III trial ADVOCATE in 331 patients with ANCA-associated vasculitis also met its primary endpoints of disease remission at week 26 and sustained remission at ...

                          Product Name : Tavneos

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          January 19, 2022

                          Lead Product(s) : Avacopan,Rituximab

                          Therapeutic Area : Immunology

                          Highest Development Status : Approved FDF

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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