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                          01

                          APGA Annual Conference
                          Not Confirmed
                          APGA Annual Conference
                          Not Confirmed

                          Details : Astrocyte AST-004, an innovative small molecule therapy, which is an adenosine A3/A1 receptor agonist, is being evaluated in Phase I clinical trial studies with patients for Acute Ischemic Stroke.

                          Product Name : AST-004

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          December 03, 2024

                          Lead Product(s) : AST-004

                          Therapeutic Area : Cardiology/Vascular Diseases

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          02

                          APGA Annual Conference
                          Not Confirmed
                          APGA Annual Conference
                          Not Confirmed

                          Details : The funding will accelerate the development of AST-004, a small molecule adenosine A3/A1 receptor agonist, aimed at treating acute brain injuries including stroke and traumatic brain injury (TBI), and further assess its potential in preclinical models of...

                          Product Name : AST-004

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          August 18, 2023

                          Lead Product(s) : AST-004

                          Therapeutic Area : Neurology

                          Highest Development Status : Preclinical

                          Sponsor : Alzheimers Drug Discovery Foundation

                          Deal Size : $6.0 million

                          Deal Type : Series B Financing

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                          03

                          APGA Annual Conference
                          Not Confirmed
                          APGA Annual Conference
                          Not Confirmed

                          Details : AST-004 is a small molecule adenosine A3/A1 receptor agonist, it is being investigated as an extended infusion for stroke and traumatic brain injuries.

                          Product Name : AST-004

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          May 04, 2023

                          Lead Product(s) : AST-004

                          Therapeutic Area : Cardiology/Vascular Diseases

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          04

                          APGA Annual Conference
                          Not Confirmed
                          APGA Annual Conference
                          Not Confirmed

                          Details : AST-004 was extremely well tolerated at all dose levels, and there have been no safety signals or significant adverse effects associated with AST-004.

                          Product Name : AST-004

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          September 14, 2022

                          Lead Product(s) : AST-004

                          Therapeutic Area : Cardiology/Vascular Diseases

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          05

                          APGA Annual Conference
                          Not Confirmed
                          APGA Annual Conference
                          Not Confirmed

                          Details : AST-004 has demonstrated a broad range of cerebroprotective efficacy when treating preclinical animal models, including preserving up to 45 percent more brain tissue in a non-human primate model of stroke, beyond that of reperfusion standard of care.

                          Product Name : AST-004

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          June 15, 2022

                          Lead Product(s) : AST-004

                          Therapeutic Area : Cardiology/Vascular Diseases

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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