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Undisclosed"},{"orgOrder":0,"company":"AstraZeneca","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Hematology","country":"UNITED KINGDOM","productType":"Protein","year":"2022","type":"Inapplicable","leadProduct":"Andexanet Alpha","moa":"Factor Xa","graph1":"Hematology","graph2":"Approved FDF","graph3":"AstraZeneca","amount2":0,"highestDevelopmentShortName":"Approved FDF","therapeuticAreaShortName":"Hematology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"AstraZeneca \/ Undisclosed","highestDevelopmentStatusID":"15","companyTruncated":"AstraZeneca \/ Undisclosed"},{"orgOrder":0,"company":"Alexion Pharmaceuticals","sponsor":"Alexion Pharmaceuticals","pharmaFlowCategory":"D","therapeuticArea":"Hematology","country":"U.S.A","productType":"Protein","year":"2020","type":"Acquisition","leadProduct":"Andexanet Alpha","moa":"Factor Xa","graph1":"Hematology","graph2":"Approved FDF","graph3":"Alexion 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                          01

                          OTS 2025
                          Not Confirmed
                          OTS 2025
                          Not Confirmed

                          Details : Andexxa (andexanet alfa) is a recombinant modified human factor Xa (FXa) protein indicated for patients treated with rivaroxaban or apixaban, when reversal of anticoagulation is needed due to life-threatening or uncontrolled bleeding.

                          Product Name : Andexxa

                          Product Type : Protein

                          Upfront Cash : Inapplicable

                          June 05, 2023

                          Lead Product(s) : Andexanet Alpha

                          Therapeutic Area : Hematology

                          Highest Development Status : Phase IV

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          02

                          OTS 2025
                          Not Confirmed
                          OTS 2025
                          Not Confirmed

                          Details : Eculizumab is a Antibody drug candidate, which is currently being evaluated in phase III clinical studies for the treatment of Atypical Hemolytic Uremic Syndrome.

                          Product Name : Undisclosed

                          Product Type : Antibody, Unconjugated

                          Upfront Cash : Inapplicable

                          May 25, 2023

                          Lead Product(s) : Eculizumab

                          Therapeutic Area : Hematology

                          Highest Development Status : Phase III

                          Recipient : Alexion Pharmaceuticals

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          03

                          OTS 2025
                          Not Confirmed
                          OTS 2025
                          Not Confirmed

                          Details : Ondexxya is the first approved medicine in Japan to specifically reverse the anticoagulant effect of FXa inhibitors apixaban, rivaroxaban or edoxaban in patients experiencing a life-threatening or uncontrolled bleed.

                          Product Name : Ondexxya

                          Product Type : Protein

                          Upfront Cash : Inapplicable

                          March 29, 2022

                          Lead Product(s) : Andexanet Alpha

                          Therapeutic Area : Hematology

                          Highest Development Status : Approved FDF

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          blank

                          04

                          OTS 2025
                          Not Confirmed
                          OTS 2025
                          Not Confirmed

                          Details : Acalabrutinib is a Other Small Molecule drug candidate, which is currently being evaluated in phase II clinical studies for the treatment of Monoclonal Gammopathy of Undetermined Significance.

                          Product Name : Undisclosed

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          October 04, 2021

                          Lead Product(s) : Acalabrutinib

                          Therapeutic Area : Hematology

                          Highest Development Status : Phase II

                          Recipient : Shayna Sarosiek, MD

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          05

                          OTS 2025
                          Not Confirmed
                          OTS 2025
                          Not Confirmed

                          Details : The safety and efficacy of roxadustat, an oral hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor, have been demonstrated in the Phase III programme including more than 8,000 patients and published in five peer-reviewed journal articles.

                          Product Name : Evrenzo

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          August 11, 2021

                          Lead Product(s) : Roxadustat

                          Therapeutic Area : Hematology

                          Highest Development Status : Approved FDF

                          Sponsor : FibroGen

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          06

                          OTS 2025
                          Not Confirmed
                          OTS 2025
                          Not Confirmed

                          Details : The safety and efficacy of roxadustat, an oral hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor, have been demonstrated in the Phase III programme including more than 8,000 patients and published in five peer-reviewed journal articles.

                          Product Name : Evrenzo

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          July 16, 2021

                          Lead Product(s) : Roxadustat

                          Therapeutic Area : Hematology

                          Highest Development Status : Approved FDF

                          Sponsor : FibroGen

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          blank

                          07

                          OTS 2025
                          Not Confirmed
                          OTS 2025
                          Not Confirmed

                          Details : ALXN1830 is a Antibody drug candidate, which is currently being evaluated in phase II clinical studies for the treatment of Anemia, Hemolytic, Autoimmune.

                          Product Name : Undisclosed

                          Product Type : Antibody, Unconjugated

                          Upfront Cash : Inapplicable

                          July 09, 2021

                          Lead Product(s) : ALXN1830

                          Therapeutic Area : Hematology

                          Highest Development Status : Phase II

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          08

                          OTS 2025
                          Not Confirmed
                          OTS 2025
                          Not Confirmed

                          Details : AZD0466 is a Other Small Molecule drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of Hematologic Diseases.

                          Product Name : Undisclosed

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          April 29, 2021

                          Lead Product(s) : AZD0466

                          Therapeutic Area : Hematology

                          Highest Development Status : Phase I

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          09

                          OTS 2025
                          Not Confirmed
                          OTS 2025
                          Not Confirmed

                          Details : Ravulizumab is a Antibody drug candidate, which is currently being evaluated in phase III clinical studies for the treatment of Thrombotic Microangiopathies.

                          Product Name : Undisclosed

                          Product Type : Antibody, Unconjugated

                          Upfront Cash : Inapplicable

                          February 08, 2021

                          Lead Product(s) : Ravulizumab

                          Therapeutic Area : Hematology

                          Highest Development Status : Phase III

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          10

                          OTS 2025
                          Not Confirmed
                          OTS 2025
                          Not Confirmed

                          Details : US FDA has requested further clarifying analyses of clinical data, to complete its review of the New Drug Application (NDA) for roxadustat, an oral hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor for patients with anaemia of chronic kidney...

                          Product Name : Evrenzo

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          December 18, 2020

                          Lead Product(s) : Roxadustat

                          Therapeutic Area : Hematology

                          Highest Development Status : Approved FDF

                          Sponsor : FibroGen

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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