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Ventures","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Other Small Molecule","year":"2020","type":"Series A Financing","leadProduct":"AB-101","moa":"||ADCC","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"Artiva Biotherapeutics","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Artiva Biotherapeutics \/ 5Am Ventures","highestDevelopmentStatusID":"7","companyTruncated":"Artiva Biotherapeutics \/ 5Am Ventures"},{"orgOrder":0,"company":"Artiva Biotherapeutics","sponsor":"Venrock Healthcare Capital Partners","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Other Small Molecule","year":"2021","type":"Series B Financing","leadProduct":"AB-101","moa":"||ADCC","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"Artiva Biotherapeutics","amount2":0,"highestDevelopmentShortName":"Ph 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Co","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Cell and Gene therapy","year":"2021","type":"Collaboration","leadProduct":"AB-MK-001","moa":"Undisclosed","graph1":"Oncology","graph2":"Discovery Platform","graph3":"Artiva Biotherapeutics","amount2":0,"highestDevelopmentShortName":"Discovery Platform","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Artiva Biotherapeutics \/ Merck & Co","highestDevelopmentStatusID":"3","companyTruncated":"Artiva Biotherapeutics \/ Merck & Co"},{"orgOrder":0,"company":"Artiva Biotherapeutics","sponsor":"Jefferies","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Other Small Molecule","year":"2024","type":"Public Offering","leadProduct":"AB-101","moa":"||ADCC","graph1":"Oncology","graph2":"Phase II","graph3":"Artiva Biotherapeutics","amount2":0,"highestDevelopmentShortName":"Ph 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Find Clinical Drug Pipeline Developments & Deals by Artiva Biotherapeutics

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                          Therapeutic Area by Lead Product

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                          Top Deals by Deal Size (USD bn)

                          01

                          CRS
                          Not Confirmed
                          CRS
                          Not Confirmed

                          Details : The net proceeds will be used to fund the clinical development of the company's lead product AlloNK (AB-101), which is being evaluated for the treatment of r/r Hodgkin Lymphoma.

                          Product Name : AlloNK

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          July 18, 2024

                          Lead Product(s) : AB-101,Acimtamig,Cyclophosphamide

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Jefferies

                          Deal Size : $167.0 million

                          Deal Type : Public Offering

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                          02

                          CRS
                          Not Confirmed
                          CRS
                          Not Confirmed

                          Details : AlloNK (AB-101) is an allogeneic NK cell therapy designed to enhance antibody-dependent cellular cytotoxicity in combination with rituximab or obinutuzumab for treating lupus nephritis.

                          Product Name : AlloNK

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          February 22, 2024

                          Lead Product(s) : AB-101,Cyclophosphamide,Rituximab

                          Therapeutic Area : Nephrology

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          03

                          CRS
                          Not Confirmed
                          CRS
                          Not Confirmed

                          Details : AlloNK (AB-101) is a non-genetically modified, cord blood-derived, allogeneic, cryopreserved, ADCC-enhancing NK cell therapy candidate for use in combination with Combination with Rituximab in Lupus Nephritis.

                          Product Name : AlloNK

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          August 16, 2023

                          Lead Product(s) : AB-101,Rituximab

                          Therapeutic Area : Immunology

                          Highest Development Status : IND Enabling

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          04

                          CRS
                          Not Confirmed
                          CRS
                          Not Confirmed

                          Details : AB-201 is an allogeneic HER2-targeted CAR-NK cell therapy for the treatment of solid tumors in the outpatient setting with the option for repeat dosing. AB-201 has demonstrated potent anti-tumor activity in multiple preclinical HER2-positive tumor model ...

                          Product Name : AB-201

                          Product Type : Protein

                          Upfront Cash : Inapplicable

                          September 20, 2022

                          Lead Product(s) : AB-201

                          Therapeutic Area : Oncology

                          Highest Development Status : IND Enabling

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          05

                          CRS
                          Not Confirmed
                          CRS
                          Not Confirmed

                          Details : AB-101, an ADCC enhancer NK-cell therapy candidate for use in combination with monoclonal antibodies or innate-cell engagers. Artiva is currently advancing a Phase 1/2 of AB-101 in combination with rituximab for the treatment of relapsed or refractory B-...

                          Product Name : AlloNK

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          May 10, 2022

                          Lead Product(s) : AB-101,Interleukin 2,Rituximab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          06

                          CRS
                          Not Confirmed
                          CRS
                          Not Confirmed

                          Details : Artiva’s pipeline includes AB-101, an ADCC enhancer NK-cell therapy which is currently under Phase 1/2 clinical trial in combination with rituximab for the treatment of relapsed or refractory B-cell lymphomas.

                          Product Name : AlloNK

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          February 26, 2021

                          Lead Product(s) : AB-101,Interleukin 2,Rituximab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Venrock Healthcare Capital Partners

                          Deal Size : $120.0 million

                          Deal Type : Series B Financing

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                          07

                          CRS
                          Not Confirmed
                          CRS
                          Not Confirmed

                          Details : The collaboration initially includes two CAR-NK programs (AB-MK-001 and AB-MK-002) with an option for a third, none of which are in Artiva’s current or planned pipeline.

                          Product Name : AB-MK-001

                          Product Type : Cell and Gene therapy

                          Upfront Cash : $30.0 million

                          January 28, 2021

                          Lead Product(s) : AB-MK-001

                          Therapeutic Area : Oncology

                          Highest Development Status : Discovery Platform

                          Sponsor : Merck & Co

                          Deal Size : $1,866.0 million

                          Deal Type : Collaboration

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                          08

                          CRS
                          Not Confirmed
                          CRS
                          Not Confirmed

                          Details : The company plans to enter the clinic this year with AB-101 in combination with an anti-CD20 monoclonal antibody for the treatment of relapsed refractory B-cell lymphoma.

                          Product Name : AlloNK

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          June 26, 2020

                          Lead Product(s) : AB-101,Undisclosed

                          Therapeutic Area : Oncology

                          Highest Development Status : IND Enabling

                          Sponsor : 5Am Ventures

                          Deal Size : $78.0 million

                          Deal Type : Series A Financing

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