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    [{"orgOrder":0,"company":"Aptose Biosciences","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"CANADA","productType":"Other Small Molecule","year":"2020","type":"Inapplicable","leadProduct":"Luxeptinib","moa":"FLT3\/BTK","graph1":"Oncology","graph2":"Phase I","graph3":"Aptose Biosciences","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Oral","sponsorNew":"Aptose Biosciences \/ Inapplicable","highestDevelopmentStatusID":"6","companyTruncated":"Aptose Biosciences \/ Inapplicable"},{"orgOrder":0,"company":"Aptose Biosciences","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"CANADA","productType":"Other Small Molecule","year":"2020","type":"Inapplicable","leadProduct":"Luxeptinib","moa":"FLT3\/BTK","graph1":"Oncology","graph2":"Phase I","graph3":"Aptose Biosciences","amount2":0,"highestDevelopmentShortName":"Ph 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Biosciences \/ Inapplicable"},{"orgOrder":0,"company":"Aptose Biosciences","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"CANADA","productType":"Other Small Molecule","year":"2022","type":"Inapplicable","leadProduct":"Luxeptinib","moa":"FLT3\/BTK","graph1":"Oncology","graph2":"Phase I","graph3":"Aptose Biosciences","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Oral Capsule","sponsorNew":"Aptose Biosciences \/ Inapplicable","highestDevelopmentStatusID":"6","companyTruncated":"Aptose Biosciences \/ Inapplicable"},{"orgOrder":0,"company":"Aptose Biosciences","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"CANADA","productType":"Other Small Molecule","year":"2020","type":"Inapplicable","leadProduct":"APTO-253","moa":"Myc expression","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"Aptose 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Biosciences","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Oral Tablet","sponsorNew":"Aptose Biosciences \/ Inapplicable","highestDevelopmentStatusID":"7","companyTruncated":"Aptose Biosciences \/ Inapplicable"}]

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                            01

                            Aptose Biosciences

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                            Aptose Biosciences

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                            Lead Product(s) : Tuspetinib,Azacitidine,Venetoclax

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Aptose Updates Tuspetinib Triple Therapy Trial in Newly Diagnosed AML

                            Details : HM43239 (tuspetinib) is an oral myeloid kinome inhibitor, is being investigated in combination with venetoclax and azacitidine as a frontline therapy for patients newly diagnosed with AML.

                            Product Name : HM43239

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            May 05, 2025

                            Lead Product(s) : Tuspetinib,Azacitidine,Venetoclax

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            02

                            Aptose Biosciences

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                            Aptose Biosciences

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                            Lead Product(s) : Tuspetinib,Azacitidine,Venetoclax

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Aptose Gets Approval for Dosing Escalation in Tuspetinib Trial

                            Details : HM43239 (tuspetinib) is an oral myeloid kinome inhibitor, is being investigated in combination with venetoclax and azacitidine as a frontline therapy for patients newly diagnosed with AML.

                            Product Name : HM43239

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            February 20, 2025

                            Lead Product(s) : Tuspetinib,Azacitidine,Venetoclax

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            03

                            Aptose Biosciences

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                            Lead Product(s) : Tuspetinib,Azacitidine,Venetoclax

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Aptose’s Tuspetinib Shows Promising Frontline Results in AML Phase 1/2

                            Details : HM43239 (tuspetinib), an oral Myeloid Kinome Inhibitor, is being investigated in combination with venetoclax and azacitidine as a frontline therapy for patients newly diagnosed with AML.

                            Product Name : HM43239

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            February 12, 2025

                            Lead Product(s) : Tuspetinib,Azacitidine,Venetoclax

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            04

                            Aptose Biosciences

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                            Aptose Biosciences

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                            Lead Product(s) : Tuspetinib,Azacitidine,Venetoclax

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Aptose Doses First AML Patients with Tuspetinib in TUSCANY Trial

                            Details : HM43239 (tuspetinib), an oral Myeloid Kinome Inhibitor, is being investigated in combination with venetoclax and azacitidine as a frontline therapy for patients newly diagnosed with AML.

                            Product Name : HM43239

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            January 09, 2025

                            Lead Product(s) : Tuspetinib,Azacitidine,Venetoclax

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            05

                            Aptose Biosciences

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                            Aptose Biosciences

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                            Lead Product(s) : Tuspetinib,Azacitidine,Venetoclax

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Aptose Initiates TUSCANY Study for Tuspetinib Triplet Therapy in Newly Diagnosed AML

                            Details : HM43239 (tuspetinib), a highly differentiated oral kinase inhibitor beng developed in combination therapy with azacitidine (AZA) and venetoclax for acute myeloid leukemia (AML).

                            Product Name : HM43239

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            November 20, 2024

                            Lead Product(s) : Tuspetinib,Azacitidine,Venetoclax

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            06

                            Aptose Biosciences

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                            Aptose Biosciences

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                            Lead Product(s) : Tuspetinib,Azacitidine,Venetoclax

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Hanmi Pharmaceutical

                            Deal Size : Undisclosed

                            Deal Type : Financing

                            DEALS_DEV arrow-down

                            Aptose Receives $10M and Negotiates Partnership with Hanmi For Tuspetinib

                            Details : Aptose will use the proceeds from such loan for the development of HM43239 (tuspetinib), a highly differentiated oral kinase inhibitor for the treatment of patients with acute myeloid leukemia (AML).

                            Product Name : HM43239

                            Product Type : Other Small Molecule

                            Upfront Cash : Undisclosed

                            August 30, 2024

                            Lead Product(s) : Tuspetinib,Azacitidine,Venetoclax

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Hanmi Pharmaceutical

                            Deal Size : Undisclosed

                            Deal Type : Financing

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                            07

                            Aptose Biosciences

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                            RDD 2025
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                            Aptose Biosciences

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                            Lead Product(s) : Tuspetinib,Venetoclax

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : The Division of Cancer Treatment and Diagnosis

                            Deal Size : Undisclosed

                            Deal Type : Agreement

                            DEALS_DEV arrow-down

                            Aptose & NCI CRADA to Develop Tuspetinib for AML/MDS in MyeloMATCH Trials

                            Details : Under the agreement, the NCI and Aptose will collaborate on the clinical development of HM43239 (tuspetinib), an inhibitor of key signaling kinases involved in r/r acute myeloid leukemia.

                            Product Name : HM43239

                            Product Type : Other Small Molecule

                            Upfront Cash : Undisclosed

                            March 12, 2024

                            Lead Product(s) : Tuspetinib,Venetoclax

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : The Division of Cancer Treatment and Diagnosis

                            Deal Size : Undisclosed

                            Deal Type : Agreement

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                            08

                            Aptose Biosciences

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                            Aptose Biosciences

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                            Lead Product(s) : Tuspetinib,Venetoclax

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Hanmi Pharmaceutical

                            Deal Size : $13.7 million

                            Deal Type : Public Offering

                            DEALS_DEV arrow-down

                            Aptose Closes $9.7 Mn Offering and $4 Mn Private Placement with Hanmi Pharmaceutical

                            Details : The net proceeds will be used for the manufacturing and clinical trials of potent inhibitor known as HM43239 (tuspetinib) for patients with relapsed or refractory acute myeloid leukemia (AML).

                            Product Name : HM43239

                            Product Type : Other Small Molecule

                            Upfront Cash : Undisclosed

                            January 31, 2024

                            Lead Product(s) : Tuspetinib,Venetoclax

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Hanmi Pharmaceutical

                            Deal Size : $13.7 million

                            Deal Type : Public Offering

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                            09

                            Aptose Biosciences

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                            Aptose Biosciences

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                            Lead Product(s) : Tuspetinib,Venetoclax

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Newbridge Securities Corporation

                            Deal Size : $8.4 million

                            Deal Type : Public Offering

                            DEALS_DEV arrow-down

                            Aptose Announces Pricing Of $8.4 Million Public Offering and $4 Million Placement

                            Details : The net proceeds to support clinical trials for HM43239, a daily oral therapy being studied as monotherapy and in combination therapy for relapsed or refractory acute myeloid leukemia.

                            Product Name : HM43239

                            Product Type : Other Small Molecule

                            Upfront Cash : Undisclosed

                            January 26, 2024

                            Lead Product(s) : Tuspetinib,Venetoclax

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Newbridge Securities Corporation

                            Deal Size : $8.4 million

                            Deal Type : Public Offering

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                            Aptose Biosciences

                            Canada arrow
                            RDD 2025
                            Not Confirmed

                            Aptose Biosciences

                            Canada arrow
                            RDD 2025
                            Not Confirmed
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                            Lead Product(s) : Tuspetinib,Venetoclax

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Hanmi Pharmaceutical

                            Deal Size : $7.0 million

                            Deal Type : Private Placement

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                            Aptose Announces Closing of $3 Million Investment by Hanmi Pharmaceutical

                            Details : The proceeds will be used for Aptose’s lead hematology drug, tuspetinib, formerly HM43239, an orally active small molecule inhibitor of FLT3, currently in Phase 1/2 trial in which patients with R/R AML receive tuspetinib monotherapy or in combination w...

                            Product Name : HM43239

                            Product Type : Other Small Molecule

                            Upfront Cash : Undisclosed

                            June 09, 2023

                            Lead Product(s) : Tuspetinib,Venetoclax

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Hanmi Pharmaceutical

                            Deal Size : $7.0 million

                            Deal Type : Private Placement

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