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Find Clinical Drug Pipeline Developments & Deals by Aptinyx
NYX-458 is an oral small molecule compound that regulates the activity of N-methyl-D-aspartate receptors in the brain. These receptors are essential for nerve cell communication, which occur at structures called synapses located at the junction between nerve cells.
NYX-783 is a novel, oral, positive allosteric modulator of NMDA receptors in Phase 2b development for the treatment of post-traumatic stress disorder (PTSD) and in Phase 1 development for the treatment of opioid use disorder (OUD).
NYX-458 is a novel oral NMDA receptor positive allosteric modulator currently in clinical development for the treatment of cognitive impairment associated with Parkinson’s disease and dementia with Lewy bodies.
NYX-2925 did not achieve statistically significant separation from placebo on the study’s primary endpoint, which assessed the change from baseline in average daily pain on the numeric rating scale (NRS) during week 12.
The poster highlights data from preclinical studies showing that NYX-783, an NMDA receptor positive allosteric modulator, builds long-lasting fear-inhibitory memories in PTSD-relevant models, ultimately leading to reduced spontaneous recovery of fear.
NYX-783, an NMDA receptor positive allosteric modulator, demonstrates an ability to build long-lasting fear-inhibitory memories in PTSD-relevant models, ultimately leading to a stabilization of fear extinction.
NYX-783, a novel NMDA receptor positive allosteric modulator signicantly reduced spontaneous recovery of fear in mice in the conventional auditory fear-conditioning model. NYX-783 also reduced spontaneous recovery in the single-prolonged stress model of PTSD.
NYX-2925, an oral NMDA receptor positive allosteric modulator did not achieve statistically significant separation from placebo on study’s primary endpoint, which assessed change from baseline in average daily pain on numeric rating scale (NRS) during week 12.
The Phase 2b study enrollment completed with 305 patients and, is evaluating the efficacy and safety of NYX-2925, a novel oral NMDA receptor positive allosteric modulator in patients with fibromyalgia.
NYX-2925, NMDA receptor positive allosteric modulator currently under evaluation in Phase 2b study in patients with painful DPN and fibromyalgia has also exhibited favorable safety and tolerability profile across a wide dose range in clinical studies.
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