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Find Clinical Drug Pipeline Developments & Deals by Aprea Therapeutics
APR-1051 is a next-generation WEE1 kinase inhibitor, which is being evaluated for the treatment of patients with cyclin E overexpressing breast and ovarian cancers.
Aprea intends to use the net proceeds to fund clinical development of APR-1051, the Company’s oral, small molecule, WEE1 inhibitor product candidate which recently received IND clearance.
APR-1051 is a next generation, oral WEE1 Kinase inhibitor. It's IND-application is submitted after preclinical studies for the treatment of cancers including ovarian cancer.
ATRN-1051 is an orally bioavailable small molecule inhibitor of WEE1 that is highly potent and selective, which is investigated for treatment of ovarian cancer.
The net proceeds received from the public offering will enable the Company to continue developing its clinical asset, ATRN-119, its pre-clinical asset ATRN-W1051 and for general corporate purposes.
The net proceeds received from the public offering will enable the Company to continue developing its clinical asset, ATRN-119, its pre-clinical asset ATRN-W1051 and for general corporate purposes.
The grant will support an evaluation of the in vivo and in vitro activity and tolerability of ATRN-119 and ATRN-W1051 using a library of cell lines and patient-derived xenograft models of HGSOC that express varying levels of CCNE1.
ATRN-119 is an ATR inhibitor for the treatment of cancers with DDR mutations. It has demonstrated potent anti-proliferative activity against a variety of cancer cell lines, inhibited tumor growth in genetically defined ovarian, colon, pancreatic etc.
ATRN-W1051 is designed to be a potent and selective WEE1 inhibitor with a differentiated structure and potentially preferable pharmacokinetic properties.
Company’s lead product candidate is eprenetapopt (APR-246), a small molecule in clinical development for hematologic malignancies and solid tumorshas not yet been approved by the USFDA or any regulatory authority.
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