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                            01

                            Alys Pharmaceuticals

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                            AIChE Annual Meeting
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                            Alys Pharmaceuticals

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                            Lead Product(s) : ALY-301

                            Therapeutic Area : Dermatology

                            Study Phase : IND Enabling

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Alys Submits CTA for ALY-301, c-Kit Inhibitor for Cold Urticaria

                            Details : ALY-301 is the first mast cell-selective c-Kit inhibitor to enter the clinic. It is a cis-targeting bispecific antibody binding c-Kit and CD-203c, allowing selective targeting of mast cells.

                            Product Name : ALY-301

                            Product Type : Antibody, Unconjugated

                            Upfront Cash : Inapplicable

                            June 10, 2025

                            Lead Product(s) : ALY-301

                            Therapeutic Area : Dermatology

                            Highest Development Status : IND Enabling

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            02

                            Alys Pharmaceuticals

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                            AIChE Annual Meeting
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                            AIChE Annual Meeting
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                            Lead Product(s) : ALY-101

                            Therapeutic Area : Dermatology

                            Study Phase : Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Alys Pharma Doses First Patient in Phase IIa Trial of ALY-101 for Alopecia Areata

                            Details : ALY-101 is designed for localized and selective inflammation modulation. It targets JAK1, a key driver of alopecia areata, using a JAK1-specific siRNA-lipid conjugate.

                            Product Name : Undisclosed

                            Product Type : Oligonucleotide

                            Upfront Cash : Inapplicable

                            March 27, 2025

                            Lead Product(s) : ALY-101

                            Therapeutic Area : Dermatology

                            Highest Development Status : Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            03

                            Alys Pharmaceuticals

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                            AIChE Annual Meeting
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                            Lead Product(s) : ALY-101

                            Therapeutic Area : Dermatology

                            Study Phase : Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Alys Gets IND Clearance for Phase 2a Genetic Medicine Trial in Dermatology

                            Details : ALY-101 is an intradermal injectable JAK1 siRNA-lipid conjugate being investigated in patients suffering from Alopecia Areata (AA).

                            Product Name : Undisclosed

                            Product Type : Oligonucleotide

                            Upfront Cash : Inapplicable

                            February 04, 2025

                            Lead Product(s) : ALY-101

                            Therapeutic Area : Dermatology

                            Highest Development Status : Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            04

                            Alys Pharmaceuticals

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                            AIChE Annual Meeting
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                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Dermatology

                            Study Phase : Preclinical

                            Sponsor : Medicxi

                            Deal Size : $100.0 million

                            Deal Type : Financing

                            DEALS_DEV arrow-down

                            Alys Pharmaceuticals Launches with $100M Financing from Medicxi for Immuno-Dermatology

                            Details : Alys will use the net proceeds to advance Immuno-Dermatology focused pipeline, including its siRNA lipid conjugate therapy for the treatment of atopic dermatitis.

                            Product Name : Undisclosed

                            Product Type : Undisclosed

                            Upfront Cash : Undisclosed

                            February 12, 2024

                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Dermatology

                            Highest Development Status : Preclinical

                            Sponsor : Medicxi

                            Deal Size : $100.0 million

                            Deal Type : Financing

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