
													
															
															Year
															DEALS // DEV.
															Country
															
															Therapeutic Area
															Study Phase
															Deal Type
															Product Type
															Dosage Form
															Lead Product
															Target

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Lead Product(s) : ESK-001
Therapeutic Area : Dermatology
Study Phase : Phase III
Recipient : Acelyrin
Deal Size : Undisclosed
Deal Type : Merger
Alumis Completes Merger with ACELYRIN
Details : Under the merger agreement, both companies will advance the developing and delivering transformative medicines such as ESK-001, which is being evaluated for the treatment of Psoriasis.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Undisclosed
May 21, 2025
Lead Product(s) : ESK-001
Therapeutic Area : Dermatology
Highest Development Status : Phase III
Recipient : Acelyrin
Deal Size : Undisclosed
Deal Type : Merger

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Lead Product(s) : ESK-001
Therapeutic Area : Nephrology
Study Phase : Phase I
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : ESK-001 is a Other Small Molecule drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of Kidney Diseases.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Inapplicable
May 08, 2025
Lead Product(s) : ESK-001
Therapeutic Area : Nephrology
Highest Development Status : Phase I
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : ESK-001
Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)
Study Phase : Phase I
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : ESK-001 is a Other Small Molecule drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of Liver Failure.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Inapplicable
May 01, 2025
Lead Product(s) : ESK-001
Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)
Highest Development Status : Phase I
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : ESK-001
Therapeutic Area : Dermatology
Study Phase : Phase III
Recipient : Acelyrin
Deal Size : Undisclosed
Deal Type : Merger
Alumis and ACELYRIN Announce Amended Merger Agreement
Details : Under the merger agreement, both companies will advance the developing and delivering transformative medicines such as ESK-001, which is being evaluated for the treatment of Psoriasis.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Undisclosed
April 21, 2025
Lead Product(s) : ESK-001
Therapeutic Area : Dermatology
Highest Development Status : Phase III
Recipient : Acelyrin
Deal Size : Undisclosed
Deal Type : Merger

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Lead Product(s) : ESK-001
Therapeutic Area : Dermatology
Study Phase : Phase III
Sponsor : Kaken Pharmaceuticals
Deal Size : $180.0 million
Deal Type : Collaboration
Alumis, Kaken Partner on ESK-001 for Dermatology in Japan
Details : The collaboration aims to develop, manufacture and commercialize ESK-001, a highly selective, next-gen oral TYK2 inhibitor, for dermatology indications in Japan.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : $40.0 million
March 25, 2025
Lead Product(s) : ESK-001
Therapeutic Area : Dermatology
Highest Development Status : Phase III
Sponsor : Kaken Pharmaceuticals
Deal Size : $180.0 million
Deal Type : Collaboration

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Lead Product(s) : ESK-001
Therapeutic Area : Dermatology
Study Phase : Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Long-term Safety and Efficacy of ESK-001 in Moderate to Severe Plaque Psoriasis
Details : ESK-001 is a Other Small Molecule drug candidate, which is currently being evaluated in phase III clinical studies for the treatment of Psoriasis.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Inapplicable
February 26, 2025
Lead Product(s) : ESK-001
Therapeutic Area : Dermatology
Highest Development Status : Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : ESK-001
Therapeutic Area : Dermatology
Study Phase : Phase III
Recipient : Acelyrin
Deal Size : Undisclosed
Deal Type : Merger
Alumis, ACELYRIN Merge to Develop Immune Disease Therapies
Details : Under the merger agreement, Both companies will advance the developing and delivering transformative medicines such as ESK-001, which is being evaluated for the treatment of Psoriasis.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Undisclosed
February 06, 2025
Lead Product(s) : ESK-001
Therapeutic Area : Dermatology
Highest Development Status : Phase III
Recipient : Acelyrin
Deal Size : Undisclosed
Deal Type : Merger

Alumis Announces Positive Phase 1 Data for CNS Penetrant TYK2 Inhibitor, A-005
Details : A-005 is a potential first-in-class, brain penetrant tyrosine kinase 2 (TYK2) inhibitor being developed for the treatment of multiple sclerosis (MS), Parkinson’s Disease.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Inapplicable
December 19, 2024

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Lead Product(s) : ESK-001
Therapeutic Area : Dermatology
Study Phase : Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : ESK-001 is a Other Small Molecule drug candidate, which is currently being evaluated in phase III clinical studies for the treatment of Psoriasis.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Inapplicable
September 19, 2024
Lead Product(s) : ESK-001
Therapeutic Area : Dermatology
Highest Development Status : Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : ESK-001
Therapeutic Area : Dermatology
Study Phase : Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : ESK-001 is a Other Small Molecule drug candidate, which is currently being evaluated in phase III clinical studies for the treatment of Psoriasis.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Inapplicable
September 19, 2024
Lead Product(s) : ESK-001
Therapeutic Area : Dermatology
Highest Development Status : Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
