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    [{"orgOrder":0,"company":"Allyx Therapeutics","sponsor":"Yale University | National Institute on Aging","pharmaFlowCategory":"DU","therapeuticArea":"Neurology","country":"U.S.A","productType":"Miscellaneous","year":"2023","type":"Inapplicable","leadProduct":"BMS-984923","moa":"Metabotropic glutamate receptor 5 (mGluR5)","graph1":"Neurology","graph2":"Phase I","graph3":"Allyx Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Capsule","sponsorNew":"Allyx Therapeutics \/ Yale University | National Institute on Aging","highestDevelopmentStatusID":"6","companyTruncated":"Allyx Therapeutics \/ Yale University | National Institute on Aging"},{"orgOrder":0,"company":"Allyx Therapeutics","sponsor":"Michael J. 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Fox Foundation","pharmaFlowCategory":"DU","therapeuticArea":"Neurology","country":"U.S.A","productType":"Miscellaneous","year":"2024","type":"Inapplicable","leadProduct":"BMS-9894923","moa":"mGluR5","graph1":"Neurology","graph2":"Phase I","graph3":"Allyx Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Capsule","sponsorNew":"Allyx Therapeutics \/ Michael J. Fox Foundation","highestDevelopmentStatusID":"6","companyTruncated":"Allyx Therapeutics \/ Michael J. Fox Foundation"}]

    Find Clinical Drug Pipeline Developments & Deals by Allyx Therapeutics

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                            01

                            Allyx Therapeutics

                            U.S.A arrow
                            AIChE Annual Meeting
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                            Allyx Therapeutics

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                            AIChE Annual Meeting
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                            Lead Product(s) : BMS-984923

                            Therapeutic Area : Neurology

                            Study Phase : Phase I

                            Sponsor : National Institutes of Health

                            Deal Size : $3.3 million

                            Deal Type : Funding

                            DEALS_DEV arrow-down

                            Allyx Therapeutics Receives $3.3M NIH Grant for ALX-001 Clinical Studies

                            Details : The funding will support Allyx’s ALX-001, a highly-selective, first-in-class, synapse-targeted, disease-modifying oral therapy in development for Alzheimer’s disease and Parkinson’s disease.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Undisclosed

                            October 15, 2024

                            Lead Product(s) : BMS-984923

                            Therapeutic Area : Neurology

                            Highest Development Status : Phase I

                            Sponsor : National Institutes of Health

                            Deal Size : $3.3 million

                            Deal Type : Funding

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                            02

                            Allyx Therapeutics

                            U.S.A arrow
                            AIChE Annual Meeting
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                            Allyx Therapeutics

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                            AIChE Annual Meeting
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                            Lead Product(s) : BMS-984923

                            Therapeutic Area : Undisclosed

                            Study Phase : Phase I

                            Sponsor : National Institute on Aging

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            A Study Evaluating the Potential of BMS-984923 to Alter the Systemic Exposure of Three Orally Administered Pro...

                            Details : BMS-984923 is a Other Small Molecule drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of undefined medical condition.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            October 09, 2024

                            Lead Product(s) : BMS-984923

                            Therapeutic Area : Undisclosed

                            Highest Development Status : Phase I

                            Sponsor : National Institute on Aging

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            03

                            Allyx Therapeutics

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                            AIChE Annual Meeting
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                            Allyx Therapeutics

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                            AIChE Annual Meeting
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                            Lead Product(s) : BMS-984923

                            Therapeutic Area : Neurology

                            Study Phase : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Allyx Therapeutics Announces First Parkinson’s Disease Patient Treated with ALX-001

                            Details : ALX-001 (previously BMS-984923) is a oral silent allosteric modulator of mGluR5, which is being evaluated for the treatment of patients with parkinson’s disease.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            September 04, 2024

                            Lead Product(s) : BMS-984923

                            Therapeutic Area : Neurology

                            Highest Development Status : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            04

                            Allyx Therapeutics

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                            AIChE Annual Meeting
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                            Allyx Therapeutics

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                            AIChE Annual Meeting
                            Not Confirmed
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                            Lead Product(s) : BMS-984923

                            Therapeutic Area : Neurology

                            Study Phase : Phase I

                            Sponsor : Yale University

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Allyx Announces First Alzheimer’s Disease Patient Treated with Lead Compound ALX-001

                            Details : ALX-001 (previously BMS-984923) is a oral silent allosteric modulator of mGluR5, which is being evaluated for the treatment of patients with alzheimer’s disease.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            June 11, 2024

                            Lead Product(s) : BMS-984923

                            Therapeutic Area : Neurology

                            Highest Development Status : Phase I

                            Sponsor : Yale University

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            05

                            Allyx Therapeutics

                            U.S.A arrow
                            AIChE Annual Meeting
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                            Allyx Therapeutics

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                            AIChE Annual Meeting
                            Not Confirmed
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                            Lead Product(s) : BMS-9894923

                            Therapeutic Area : Neurology

                            Study Phase : Phase I

                            Sponsor : Michael J. Fox Foundation

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            A Study to Assess the Safety of BMS-984923 Compared to Placebo, in People With Parkinson's

                            Details : BMS-9894923 is a Other Small Molecule drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of Parkinson Disease.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            March 13, 2024

                            Lead Product(s) : BMS-9894923

                            Therapeutic Area : Neurology

                            Highest Development Status : Phase I

                            Sponsor : Michael J. Fox Foundation

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            06

                            Allyx Therapeutics

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                            AIChE Annual Meeting
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                            Allyx Therapeutics

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                            Lead Product(s) : BMS-984923

                            Therapeutic Area : Neurology

                            Study Phase : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Allyx Therapeutics Announces Positive Phase 1b Data and Advances ALX-001 to Patients

                            Details : BMS-984923 (ALX-001) is a highly selective, first-in-class, synapse-targeted, disease-modifying oral therapy, which is being evaluated for the treatment of Alzheimer’s and Parkinson’s disease.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            March 11, 2024

                            Lead Product(s) : BMS-984923

                            Therapeutic Area : Neurology

                            Highest Development Status : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            07

                            Allyx Therapeutics

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                            AIChE Annual Meeting
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                            Allyx Therapeutics

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                            AIChE Annual Meeting
                            Not Confirmed
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                            Lead Product(s) : BMS-984923

                            Therapeutic Area : Neurology

                            Study Phase : IND Enabling

                            Sponsor : Bristol Myers Squibb

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Allyx Expands into Parkinson's Disease Research with ALX-001 Following IND Acceptance

                            Details : ALX-001 is a highly selective, first-in-class, synapse-targeted, disease-modifying oral therapy for neurodegenerative diseases. It is being evaluated for the treatment of Parkinson’s Disease.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            March 05, 2024

                            Lead Product(s) : BMS-984923

                            Therapeutic Area : Neurology

                            Highest Development Status : IND Enabling

                            Sponsor : Bristol Myers Squibb

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            08

                            Allyx Therapeutics

                            U.S.A arrow
                            AIChE Annual Meeting
                            Not Confirmed

                            Allyx Therapeutics

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                            AIChE Annual Meeting
                            Not Confirmed
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                            Lead Product(s) : BMS-984923

                            Therapeutic Area : Neurology

                            Study Phase : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Allyx Therapeutics Lead Compound ALX-001 is Safe and Tolerable at Doses, Achieving Full Brain Target Engagemen...

                            Details : ALX-001 (previously BMS-984923) is a oral silent allosteric modulator of mGluR5, and the first-in-class compound that selectively blocks the pathogenic activation of the receptor while preserving normal glutamate signaling, being investigated for neurode...

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            October 30, 2023

                            Lead Product(s) : BMS-984923

                            Therapeutic Area : Neurology

                            Highest Development Status : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            09

                            Allyx Therapeutics

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                            AIChE Annual Meeting
                            Not Confirmed

                            Allyx Therapeutics

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                            AIChE Annual Meeting
                            Not Confirmed
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                            Lead Product(s) : BMS-984923

                            Therapeutic Area : Neurology

                            Study Phase : Phase I

                            Sponsor : Michael J. Fox Foundation

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Food Effect Study of BMS-984923 in Healthy Older Adult Volunteers

                            Details : BMS-984923 is a Other Small Molecule drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of Alzheimer Disease.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            April 18, 2023

                            Lead Product(s) : BMS-984923

                            Therapeutic Area : Neurology

                            Highest Development Status : Phase I

                            Sponsor : Michael J. Fox Foundation

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            10

                            Allyx Therapeutics

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                            AIChE Annual Meeting
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                            Allyx Therapeutics

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                            Lead Product(s) : BMS-984923

                            Therapeutic Area : Neurology

                            Study Phase : Phase I

                            Sponsor : Yale University | National Institute on Aging

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            A Multiple Ascending Dose Study in Healthy Volunteers and Patients With Alzheimer's Disease

                            Details : BMS-984923 is a Other Small Molecule drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of Alzheimer Disease.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            April 07, 2023

                            Lead Product(s) : BMS-984923

                            Therapeutic Area : Neurology

                            Highest Development Status : Phase I

                            Sponsor : Yale University | National Institute on Aging

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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