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                          Therapeutic Area by Lead Product

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                          Top Deals by Deal Size (USD bn)

                          01

                          AAPS National Biotech
                          Not Confirmed
                          AAPS National Biotech
                          Not Confirmed

                          Details : Allena recently completed a Phase 1b multiple ascending dose study of ALLN-346. The study included 18 healthy volunteers, who received either ALLN-346 or placebo (2:1 randomization) for seven days.

                          Product Name : ALLN-346

                          Product Type : Enzyme

                          Upfront Cash : Inapplicable

                          September 29, 2021

                          Lead Product(s) : Engineered Urate Oxidase

                          Therapeutic Area : Rheumatology

                          Highest Development Status : Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          02

                          AAPS National Biotech
                          Not Confirmed
                          AAPS National Biotech
                          Not Confirmed

                          Details : Allena’s lead product candidate, reloxaliase (formerly ALLN-177), is a first-in-class, non-absorbed, orally-administered enzyme for the treatment of hyperoxaluria.

                          Product Name : ALLN-177

                          Product Type : Enzyme

                          Upfront Cash : Undisclosed

                          July 14, 2021

                          Lead Product(s) : Reloxaliase

                          Therapeutic Area : Gastroenterology

                          Highest Development Status : Phase III

                          Sponsor : H.C. Wainwright & Co

                          Deal Size : $28.0 million

                          Deal Type : Public Offering

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                          03

                          AAPS National Biotech
                          Not Confirmed
                          AAPS National Biotech
                          Not Confirmed

                          Details : Company is developing ALLN-346 for the treatment of hyperuricemia and gout in the setting of advanced CKD, with a Phase 1 multiple ascending dose study recently completed and a Phase 2a program underway.

                          Product Name : ALLN-346

                          Product Type : Enzyme

                          Upfront Cash : Inapplicable

                          March 11, 2021

                          Lead Product(s) : Engineered Urate Oxidase

                          Therapeutic Area : Rheumatology

                          Highest Development Status : Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          04

                          AAPS National Biotech
                          Not Confirmed
                          AAPS National Biotech
                          Not Confirmed

                          Details : Allena now plans to reducing target enrollment to 200 subjects. Conducting earlier interim analysis, expected in Q3 2021.

                          Product Name : ALLN-177

                          Product Type : Enzyme

                          Upfront Cash : Inapplicable

                          December 02, 2020

                          Lead Product(s) : Reloxaliase

                          Therapeutic Area : Nephrology

                          Highest Development Status : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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