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Morgan"},{"orgOrder":0,"company":"Aeglea BioTherapeutics","sponsor":"Fairmount Funds Management LLC","pharmaFlowCategory":"D","therapeuticArea":"Gastroenterology","country":"U.S.A","productType":"Other Large Molecule","year":"2023","type":"Private Placement","leadProduct":"SPY001","moa":"Alpha-4-beta-7 integrin","graph1":"Gastroenterology","graph2":"Preclinical","graph3":"Aeglea BioTherapeutics","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Gastroenterology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Aeglea BioTherapeutics \/ Fairmount Funds Management LLC","highestDevelopmentStatusID":"4","companyTruncated":"Aeglea BioTherapeutics \/ Fairmount Funds Management LLC"}]

Find Clinical Drug Pipeline Developments & Deals by Aeglea BioTherapeutics

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                          Top Deals by Deal Size (USD bn)

                          01

                          Vietnam Medi Pharm
                          Not Confirmed
                          Vietnam Medi Pharm
                          Not Confirmed

                          Details : ACN00177 (pegtarviliase) is a novel recombinant human enzyme engineered to reduce elevated levels of total homocysteine, for the treatment of classical homocystinuria.

                          Product Name : ACN00177

                          Product Type : Enzyme

                          Upfront Cash : Inapplicable

                          December 04, 2023

                          Lead Product(s) : Pegtarviliase

                          Therapeutic Area : Rare Diseases and Disorders

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          02

                          Vietnam Medi Pharm
                          Not Confirmed
                          Vietnam Medi Pharm
                          Not Confirmed

                          Details : Under the agreement, Immedica gains global rights of AEB1102 (pegzilarginase), a novel recombinant human enzyme engineered to degrade the amino acid arginine, for the treatment of rare metabolic disease Arginase 1 Deficiency.

                          Product Name : AEB1102

                          Product Type : Enzyme

                          Upfront Cash : $15.0 million

                          July 27, 2023

                          Lead Product(s) : Pegzilarginase

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase III

                          Sponsor : Immedica Pharma

                          Deal Size : $115.0 million

                          Deal Type : Agreement

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                          03

                          Vietnam Medi Pharm
                          Not Confirmed
                          Vietnam Medi Pharm
                          Not Confirmed

                          Details : The company intends to use the net proceeds in advancing a leading inflammatory bowel disease (IBD) portfolio including, SPY001 and SPY002, that are potentially best-in-class antibodies targeting a 4 b 7 and TL1A, respectively.

                          Product Name : SPY001

                          Product Type : Other Large Molecule

                          Upfront Cash : Undisclosed

                          June 22, 2023

                          Lead Product(s) : SPY001

                          Therapeutic Area : Gastroenterology

                          Highest Development Status : Preclinical

                          Sponsor : Fairmount Funds Management LLC

                          Deal Size : $210.0 million

                          Deal Type : Private Placement

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                          04

                          Vietnam Medi Pharm
                          Not Confirmed
                          Vietnam Medi Pharm
                          Not Confirmed

                          Details : AEB1102 (pegzilarginase) is a novel, recombinant human arginase 1 enzyme that in clinical trials has been shown to normalize the elevated levels of the amino acid arginine in patients with ARG1-D, a rare, progressive disease characterized by high levels ...

                          Product Name : AEB1102

                          Product Type : Enzyme

                          Upfront Cash : Inapplicable

                          August 18, 2022

                          Lead Product(s) : Pegzilarginase

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          05

                          Vietnam Medi Pharm
                          Not Confirmed
                          Vietnam Medi Pharm
                          Not Confirmed

                          Details : In PEACE Phase 3 clinical trial, treatment with pegzilarginase was shown to markedly reduce blood arginine levels in patients with ARG1-D, also has received several regulatory designations from the U.S.FDA as well as Orphan drug designation from the EMA.

                          Product Name : AEB1102

                          Product Type : Enzyme

                          Upfront Cash : Inapplicable

                          March 29, 2022

                          Lead Product(s) : Pegzilarginase

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          06

                          Vietnam Medi Pharm
                          Not Confirmed
                          Vietnam Medi Pharm
                          Not Confirmed

                          Details : Pegzilarginase met its primary endpoint with a statistically significant reduction in plasma arginine from baseline after 24 weeks of treatment is a First potential therapy to address key driver of ARG1-D, a devastating ultra-rare disease.

                          Product Name : AEB1102

                          Product Type : Enzyme

                          Upfront Cash : Inapplicable

                          June 12, 2021

                          Lead Product(s) : Pegzilarginase

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          07

                          Vietnam Medi Pharm
                          Not Confirmed
                          Vietnam Medi Pharm
                          Not Confirmed

                          Details : Result showed Phase 3 study, PEACE (Pegzilarginase Effect on Arginase 1 Deficiency Clinical Endpoints), met the primary endpoint with a statistically significant reduction in plasma arginine from baseline after 24 weeks of treatment.

                          Product Name : AEB1102

                          Product Type : Enzyme

                          Upfront Cash : Inapplicable

                          May 12, 2021

                          Lead Product(s) : Pegzilarginase

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          08

                          Vietnam Medi Pharm
                          Not Confirmed
                          Vietnam Medi Pharm
                          Not Confirmed

                          Details : Aeglea BioTherapeutics will supply pegzilarginase, a novel, recombinant human arginase 1 enzyme that has been shown to lower toxic levels of the amino acid arginine in patients with Arginase 1 Deficiency (ARG1-D).

                          Product Name : AEB1102

                          Product Type : Enzyme

                          Upfront Cash : $21.5 million

                          March 22, 2021

                          Lead Product(s) : Pegzilarginase

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase III

                          Sponsor : Immedica Pharma

                          Deal Size : $151.5 million

                          Deal Type : Licensing Agreement

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                          09

                          Vietnam Medi Pharm
                          Not Confirmed
                          Vietnam Medi Pharm
                          Not Confirmed

                          Details : Aeglea BioTherapeutics has completed patient randomization for PEACE (Pegzilarginase Effect on Arginase 1 Deficiency Clinical Endpoints), the pivotal Phase 3 clinical trial investigating pegzilarginase for the treatment of Arginase 1 Deficiency (ARG1-D).

                          Product Name : AEB1102

                          Product Type : Enzyme

                          Upfront Cash : Inapplicable

                          March 05, 2021

                          Lead Product(s) : Pegzilarginase

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          10

                          Vietnam Medi Pharm
                          Not Confirmed
                          Vietnam Medi Pharm
                          Not Confirmed

                          Details : New 56 week analysis on Arginase 1 Deficiency patients who have been treated with pegzilarginase showed that Pegzilarginase was shown to have a favorable safety profile with more than 750 doses administered.

                          Product Name : AEB1102

                          Product Type : Enzyme

                          Upfront Cash : Inapplicable

                          May 26, 2020

                          Lead Product(s) : Pegzilarginase

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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