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Find Clinical Drug Pipeline Developments & Deals by Adaptimmune Therapeutics
The combined company will utilize engineered T-cell therapies targeting MAGE-A4 and mesothelin. These targets are expressed on a broad range of solid tumors and are supported by compelling early- and late-stage clinical data.
44% Objective Response Rate (ORR) with a single dose of ADP-A2M4CD8 in 25 heavily pre-treated patients with late-stage ovarian, urothelial, and head & neck cancers.
Adaptimmune applied their lentiviral technology to TILs engineering them to express IL-7 (ADP-TILIL7) intended to improve clinical responses, produced levels of IL-7 shown to improve growth and survival in vitro.
Results from this large dataset are consistent with data previously shared by the Company and support MAGE-A4 as an important cancer target within the tumor types currently included in ongoing clinical trials of afami-cel and ADP-A2M4CD8.
Post-infusion biopsies indicated that infiltrating afami-cel SPEAR T-cells co-localize with tumor and additional immune cells, with evidence of activated and proliferative state and adaptive-immune response.
Lead Product(s):
Afamitresgene Autoleucel
Therapeutic Area:OncologyProduct Name: SPEAR T Cells
Highest Development Status:Phase IProduct Type: Cell and Gene therapy
Partner/Sponsor/Collaborator:
Not Applicable
Deal Size: Not ApplicableUpfront Cash: Not Applicable
Afamitresgene autoleucel or ADP-A2M4 (MAGE-A4) SPEAR T-cell therapy is directed to a member of the MAGE family of cancer testis antigen expressed in a number of solid tumor cell types.
Adaptimmune will be responsible for developing clinical candidates using its induced pluripotent stem cell (iPSC) derived allogeneic platform to develop allogeneic T-cell therapies for up to five shared cancer targets and personalized allogeneic T-cell therapies.
The study revealed that DP-A2AFP has an acceptable safety profile with no reports of significant T-cell
related hepatotoxicity and no protocol-defined dose limiting toxicities.
Lead Product(s):
Autologous Genetically Modified AFPᶜ³³²T Cells
Company will present abstract title: "In vitro selection and engineering of a human leukocyte antigen-independent T-cell receptor recognizing human mesothelin", at the American Society for Cell and Gene Therapy (ASGCT) meeting.
In vitro translational data in the SURPASS trial indicate that co-expression of the CD8α co-receptor on CD4+ ADP-A2M4 SPEAR T-cells enables them to kill MAGE-A4 expressing target cells with equal potency as CD8+ SPEAR T-cells.
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