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Find Clinical Drug Pipeline Developments & Deals by Actinium pharmaceuticals
Iomab-B (apamistamab-I-131) is a murine monoclonal antibody in conjugation with iodine-131 (131I), which is being evaluated for the treatment of relapsed or refractory (r/r) acute myeloid leukemia.
The funding will support company's clinical collaboration with MSK to study Iomab-ACT (apamistamab-I-131), its CD45-targeting radiotherapeutic, for targeted conditioning to achieve lymphodepletion therapy prior to administration of a CD19-targeted CAR-T cell therapy.
Iomab-B links apamistamab to the radioisotope iodine-131 and once attached to its target cells emits energy that travels a relatively long distance, destroying a patient's cancer cells and ablating their bone marrow. It is being developed for AML.
Iomab-B links apamistamab to the radioisotope iodine-131 and once attached to its target cells emits energy that travels a relatively long distance, destroying a patient's cancer cells and ablating their bone marrow.
Under the terms of the CRADA, the NCI will serve as sponsor for any clinical trials mutually approved by both parties to study Actimab-A (lintuzumab-Ac225) while Actinium will be responsible for supplying and distributing Actimab-A.
Lomab-B (apamistamab-I-131) is a first-in-class targeted radiotherapy intended to improve patient access to potentially curative BMT by simultaneously and rapidly depleting blood cancer, immune and bone marrow stem cells that uniquely express CD45.
Actimab-A (lintuzumab-Ac-225) is an Actinium-225 based antibody radiation conjugate targeting CD33, a validated target that is expressed in virtually all patients with AML. Actimab-A due to its radiation modality is agnostic to cytogenetics.
Patients on study of Actimab-A (Lintuzumab-Ac225) received a median of 2 lines of prior therapy with 57% receiving prior treatment with venetoclax and 67% had adverse cytogenetics with 52% of patients having a TP53 mutation.
Iomab-B (apamistamab-I-131) is a first-in-class targeted radiotherapy intended to improve patient access to potentially curative BMT by simultaneously and rapidly depleting blood cancer, immune and bone marrow stem cells that uniquely express CD45.
Iomab-B (apamistamab-I-131) via the monoclonal antibody apamistamab, targets CD45, an antigen widely expressed on all types of blood cancer cells and immune cells including bone marrow progenitor stems cells.
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