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Find Clinical Drug Pipeline Developments & Deals by 9 Meters Biopharma
NM-002 (vurolenatide), a proprietary long-acting GLP-1 agonist for short bowel syndrome as well as an anti-GIP monoclonal antibody and plans to conduct a Phase 3 trial with vurolenatide in patients with short bowel syndrome.
NM-136 is a novel humanized monoclonal antibody antagonist targeting glucose-dependent insulinotropic polypeptide (GIP). Pre-clinical data has demonstrated that anti-GIP monoclonal antibodies can effectively produce weight loss in obese mice without affecting food consumption.
The Company intends to use the net proceeds, to support the clinical development of NM-002 (vurolenatide) for the treatment of short bowel syndrome and to fund the development of the Company's other pipeline programs.
The Company intends to use the net proceeds, to support the clinical development of NM-002 (vurolenatide) for the treatment of short bowel syndrome and to fund the development of the Company's other pipeline programs.
The therapeutic effect of immune checkpoint inhibitors (ICIs), such as antibodies to CTLA-4 and PD-1, might be enhanced by preventing bacterial antigens, toxins, and certain metabolites in the gut from interacting with the host immune system utilizing NM-102.
NM-136, an anti-GIP humanized mAb, for targeted obesity disorders has demonstrated that the anti-GIP hu-mAb has a robust half-life, excellent humanness score, a high affinity for the GIP receptor.
Vurolenatide (NM-002) 50 mg every two weeks (Q2W) dosing arm demonstrated a 30% reduction over six weeks in the primary endpoint of the Phase 2 study, mean reduction in total stool output (TSO), compared with a 32% increase for placebo - for a mean relative reduction of 62%.
NM-002 (vurolenatide) is long-acting injectable GLP-1 receptor agonist that utilizes XTEN® technology to extend its circulating half-life. GLP-1, referred to "ileal brake", is hormone that slows transit of food and fluid through stomach and upper intestine following meal.
This study follows a Phase 2 clinical trial in 342 adult patients with celiac disease who had been on a gluten-free diet for at least 12 months, which concluded that INN-202 (larazotide) 0.5 mg significantly reduced symptoms of celiac disease.
Vurolenatide, a novel chemical entity and long-acting injectable GLP-1 receptor agonist used to improve gastric motility. Company initiated the largest placebo-controlled Phase 2 trial in treatment of Short Bowel Syndrome.