Larylin Husten Lser

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Also known as: 23828-92-4, Ambroxol hcl, Mucoangin, Mucosolvan, Trans-4-((2-amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, Ambroxolhydrochloride

Molecular Formula

C₁₃H₁₉Br₂ClN₂O

Molecular Weight

414.56 g/mol

InChI Key

QNVKOSLOVOTXKF-UHFFFAOYSA-N

FDA UNII

R3593UZ7HS

A metabolite of BROMHEXINE that stimulates mucociliary action and clears the air passages in the respiratory tract. It is usually administered as the hydrochloride.

1 2D Structure

Larylin Husten Lser

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

4-[(2-amino-3,5-dibromophenyl)methylamino]cyclohexan-1-ol;hydrochloride

2.1.2 InChI

InChI=1S/C13H18Br2N2O.ClH/c14-9-5-8(13(16)12(15)6-9)7-17-10-1-3-11(18)4-2-10;/h5-6,10-11,17-18H,1-4,7,16H2;1H

2.1.3 InChI Key

QNVKOSLOVOTXKF-UHFFFAOYSA-N

2.2 Other Identifiers

2.2.1 UNII

R3593UZ7HS

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 4-(((2-amino-3,5-dibromophenyl)methyl)amino)cyclohexanol

2. Abrohexal

3. Am, Bisolvon

4. Ambril

5. Ambro Puren

6. Ambro-puren

7. Ambrobeta

8. Ambrofur

9. Ambrohexal

10. Ambrols

11. Ambrolitic

12. Ambropp

13. Ambropuren

14. Ambroten

15. Ambroxin

16. Ambroxocompren

17. Ambroxol

18. Bisolvon Am

19. Bromhexine Metabolite Viii

20. Bronchopront

21. Bronchowern

22. Broxol

23. Contac Husten Trunk

24. Contac Husten-trunk

25. Contac Hustentrunk

26. Dinobroxol

27. Duramucal

28. Ebromin

29. Expeflen

30. Expit

31. Farmabroxol

32. Flavamed

33. Frenopect

34. Gelopol

35. Hustenlser, Pect

36. Hustenlser, Therapin

37. Larylin Husten Lser

38. Larylin Husten-lser

39. Larylin Hustenlser

40. Lasolvan

41. Metabolite Viii, Bromhexine

42. Mibrox

43. Motosol

44. Muco Fips

45. Muco-fips

46. Mucofips

47. Mucosolvan

48. Mucotablin

49. Na 872

50. Na-872

51. Na872

52. Pdiamuc

53. Pect Hustenlser

54. Pulmonal S

55. Pulmonal, Ringelheimer

56. Ringelheimer Pulmonal

57. Sekretovit

58. Stas Hustenlser

59. Stas-hustenlser

60. Stashustenlser

61. Surbronc

62. Therapin Hustenlser

2.3.2 Depositor-Supplied Synonyms

1. 23828-92-4

2. Ambroxol Hcl

3. Mucoangin

4. Mucosolvan

5. Trans-4-((2-amino-3,5-dibromobenzyl)amino)cyclohexanol Hydrochloride

6. Ambroxolhydrochloride

7. Cc995zmv90

8. Dtxsid2045442

9. Nsc-758224

10. Mucolear

11. Ambroxol Lozenge

12. Na 872 Hydrochloride

13. Unii-cc995zmv90

14. Hustless

15. Ccris 8686

16. Trans-4-[(2-amino-3,5-dibromobenzyl)amino]cyclohexanol Hydrochloride

17. Einecs 245-899-2

18. Ambroxol Hci, Ep8.0

19. Dtxcid0025442

20. Ambroxol Hydrochloride [mart.]

21. Nsc 758224

22. Ambroxol Hydrochloride [ep Impurity]

23. Ambroxol Hydrochloride [ep Monograph]

24. Cyclohexanol, 4-((2-amino-3,5-dibromobenzyl)amino)-, Hydrochloride, Trans-

25. Cyclohexanol, 4-(n-(2-amino-3,5-dibromobenzyl)amino)-, Hydrochloride (e)-

26. Cyclohexanol, 4-(((2-amino-3,5-dibromophenyl)methyl)amino)-, Monohydrochloride, Trans-

27. 245-899-2

28. 1384955-66-1

29. 1146648-86-3

30. 15942-05-9

31. Cis-ambroxol Hydrochloride

32. 4-((2-amino-3,5-dibromobenzyl)amino)cyclohexan-1-ol Hydrochloride

33. Lasolvan

34. Cis-4-((2-amino-3,5-dibromobenzyl)amino)cyclohexanol Hydrochloride

35. Ambroxol Impurity D Hcl

36. Ambroxol Impurity D Hydrochloride

37. Ambroxol Hydrochloride [jan]

38. Ambroxol (hydrochloride)

39. Mfcd00078932

40. Ambroxol Hydrochloride, Cis-

41. R3593uz7hs

42. Na-872

43. 4-[(2-amino-3,5-dibromophenyl)methylamino]cyclohexan-1-ol;hydrochloride

44. Ambroxol Hydrochloride (jan)

45. Ambroxol Hydrochloride 100 Microg/ml In Acetonitrile

46. Cis-4-[(2-amino-3,5-dibromobenzyl)amino]cyclohexanol Hydrochloride

47. (1r,4r)-4-((2-amino-3,5-dibromobenzyl)amino)cyclohexan-1-ol Hydrochloride

48. Cyclohexanol, 4-(((2-amino-3,5-dibromophenyl)methyl)amino)-, Hydrochloride (1:1), Cis-

49. Smr000875269

50. Ncgc00016781-04

51. Cas-23828-92-4

52. Lazolvan

53. Ponophen

54. Mucosolvan-l

55. Sr-05000001463

56. Mucosal-l

57. Hustless (tn)

58. Ambroxol Hydrochloride Imp. D (ep); Ambroxol Imp. D (ep); Cis-4-[(2-amino-3,5-dibromobenzyl)amino]cyclohexanol Hydrochloride; Ambroxol Hydrochloride Imp. D (ep) As Hydrochloride; Ambroxol Hydrochloride Impurity D As Hydrochloride; Ambroxol Impurity D As Hydrochloride

59. Prestwick_717

60. Ambroxol Hydrochlolide

61. Unii-r3593uz7hs

62. Schembl99455

63. Ambroxol Hydrochloride, 98%

64. Mls001333105

65. Mls001333106

66. Mls002153788

67. Spectrum1503080

68. (e)-4-hdmb

69. Hy-b1039ar

70. Na-872et

71. Chembl1514634

72. Chebi:31198

73. Hy-b1039a

74. Dtxsid60936098

75. Exr-202

76. Qnvkoslovotxkf-pfwpskeqsa-n

77. Ambroxol Hcl - Bio-x Trade Mark

78. Hms1569i13

79. Hms1922c19

80. Pharmakon1600-01503080

81. Ambroxol Hydrochloride [mi]

82. Bcp04490

83. Ambroxol (hydrochloride) (standard)

84. Tox21_110607

85. Ac-024

86. Ccg-39174

87. Nsc758224

88. S3064

89. Akos015895175

90. Akos015951294

91. Akos024462505

92. Ambroxol Hydrochloride [who-dd]

93. Bcp9000284

94. Ccg-220366

95. Fa17345

96. Ks-5248

97. Ncgc00016781-03

98. Ncgc00092387-01

99. Ncgc00094999-01

100. Ncgc00094999-02

101. Ba166015

102. Sy052506

103. Ambroxol Hydrochloride, Analytical Standard

104. Bcp0726000073

105. A2360

106. Cs-0013219

107. Ns00084420

108. Sw198832-2

109. D01479

110. H11915

111. Sr-01000837516

112. Sr-01000837516-3

113. Sr-05000001463-2

114. Q27275396

115. F1131-0002

116. 2-amino-3,5-dibromo-n-(trans-4-hydroxycyclohexyl)benzylamine

117. Ambroxol Hydrochloride 1.0 Mg/ml In Methanol (as Free Base)

118. Trans-4-(2-amino-3,5-dibromobenzyl)aminocyclohexanol Hydrochloride

119. Trans-4-(2-amino-3,5-dibromobenzylamino)cyclohexanol Hydrochloride

120. Ambroxol Hydrochloride, European Pharmacopoeia (ep) Reference Standard

121. Cyclohexanol, 4-[[(2-amino-3,5-dibromophenyl)methyl]amino]-, Hydrochloride

122. Cyclohexanol,4-[[(2-amino-3,5-dibromophenyl)methyl]amino]-,hydrochloride

123. Trans-4-((2-amino-3,5-dibromobenzyl)-amino)cyclohexanol Hydrochloride

124. Trans-4-((2-amino-3,5-dibromobenzyl)amino)-cyclohexanol Hydrochloride

125. 4-{[(2-amino-3,5-dibromophenyl)methyl]amino}cyclohexan-1-ol--hydrogen Chloride (1/1)

126. Imp. D (ep): Cis-4-[(2-amino-3,5-dibromobenzyl)amino]-cyclohexanol Hcl

127. Trans-4-(((2-amino-3,5-dibromophenyl)methyl)amino)cyclohexan-1-ol Hydrochloride

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₁₃H₁₉Br₂ClN₂O
Molecular Weight	414.56 g/mol
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	3
Exact Mass	Da
Monoisotopic Mass	Da
Topological Polar Surface Area	58.3
Heavy Atom Count	19
Formal Charge	0
Complexity	259
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Expectorants

Agents that increase mucous excretion. Mucolytic agents, that is drugs that liquefy mucous secretions, are also included here. (See all compounds classified as Expectorants.)

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