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    CAS 6640-24-0
    Also known as: 6640-24-0, M-chlorophenylpiperazine, 3-chlorophenyl piperazine, M-cpp, 1-(m-chlorophenyl)piperazine, 3-chlorophenylpiperazine
    Molecular Formula
    C10H13ClN2
    Molecular Weight
    196.67  g/mol
    InChI Key
    VHFVKMTVMIZMIK-UHFFFAOYSA-N
    FDA UNII
    REY0CNO998
    m-Chlorophenylpiperazine has been used in trials studying the treatment of Alcoholism.
    1 2D Structure

    CAS 6640-24-0

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    1-(3-chlorophenyl)piperazine
    2.1.2 InChI
    InChI=1S/C10H13ClN2/c11-9-2-1-3-10(8-9)13-6-4-12-5-7-13/h1-3,8,12H,4-7H2
    2.1.3 InChI Key
    VHFVKMTVMIZMIK-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    C1CN(CCN1)C2=CC(=CC=C2)Cl
    2.2 Other Identifiers
    2.2.1 UNII
    REY0CNO998
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 1-(3-chlorophenyl)piperazine Dihydrochloride

    2. 1-(3-chlorophenyl)piperazine Monohydrochloride

    3. 1-(m-chlorophenyl)piperazine

    4. 1-3-cpp

    5. 3-chlorophenylpiperazine

    6. Dihydrochloro Phenyl Piperazine

    7. M-chlorophenylpiperazine

    8. M-cpp

    9. Meta-chlorophenylpiperazine

    2.3.2 Depositor-Supplied Synonyms

    1. 6640-24-0

    2. M-chlorophenylpiperazine

    3. 3-chlorophenyl Piperazine

    4. M-cpp

    5. 1-(m-chlorophenyl)piperazine

    6. 3-chlorophenylpiperazine

    7. 1-(3-chlorophenyl) Piperazine

    8. Piperazine, (3-chlorophenyl)-

    9. Chembl478

    10. Rey0cno998

    11. 1-(3-chlorophenyl)-piperazine (m-cpp)

    12. Chebi:10588

    13. Nsc-49307

    14. Ncgc00015247-04

    15. Dsstox_cid_25138

    16. Dsstox_rid_80696

    17. Dsstox_gsid_45138

    18. Meta-chlorophenylpiperazine

    19. Nsc 49307

    20. Cas-6640-24-0

    21. 1-(3-chlorophenyl)-piperazine

    22. 1-(3-chlorophenyl)piperazinehydrochloride

    23. Einecs 229-654-7

    24. Unii-rey0cno998

    25. Meta Chlorophenyl Piperazine

    26. N-(3-chlorophenyl)piperazine

    27. 4-(3-chlorophenyl)piperazine

    28. 1-(3-chloro Phenyl)piperazine

    29. Piperazine, 1-(3-chlorophenyl)-

    30. Tocris-0875

    31. 3cpp

    32. Lopac-c-5554

    33. (m-cpp)

    34. Biomol-nt_000129

    35. Ec 229-654-7

    36. Meta-chlorophenyl-piperazine

    37. (3-chlorophenyl)-piperazine

    38. Lopac0_000245

    39. Schembl48931

    40. 4-(m-chlorophenyl)piperazine

    41. Gtpl142

    42. (3-chloro-phenyl)-piperazine

    43. N-(m-chlorophenyl)-piperazine

    44. 4-(3-chlorophenyl)-piperazine

    45. Bpbio1_000067

    46. Zinc4285

    47. Dtxsid9045138

    48. 1-(3-chloro-phenyl)-piperazine

    49. M-chlorophenylpiperazine (m-cpp)

    50. Piperazine, 1-(m-chlorophenyl)-

    51. Albb-005970

    52. Bcp15052

    53. Cs-d0555

    54. Nsc49307

    55. Tox21_110110

    56. Bdbm50001915

    57. Pdsp1_000002

    58. Pdsp2_000002

    59. Stk397316

    60. Akos000101295

    61. Tox21_110110_1

    62. 1-m-chlorophenyl Piperazine Metabolite

    63. Ccg-204340

    64. Db12110

    65. Gf-0110

    66. Ncgc00015247-01

    67. Ncgc00015247-02

    68. Ncgc00015247-03

    69. Ncgc00015247-05

    70. Ncgc00015247-07

    71. Ncgc00024836-01

    72. Ncgc00024836-02

    73. Ncgc00024836-03

    74. Ac-23379

    75. Db-024578

    76. J227.960f

    77. A8960

    78. Bb 0254666

    79. Aj-333/09217060

    80. L000009

    81. Q286112

    82. W-104754

    83. Brd-k75844781-001-01-9

    84. Brd-k75844781-003-03-1

    85. 1-(m-chlorophenyl)piperazine; 4-(3-chlorophenyl)piperazine; N-(3-chlorophenyl)piperazine; N-(m-chlorophenyl)piperazine

    2.4 Create Date
    2005-03-25
    3 Chemical and Physical Properties
    Molecular Weight 196.67 g/mol
    Molecular Formula C10H13ClN2
    XLogP31.7
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count2
    Rotatable Bond Count1
    Exact Mass196.0767261 g/mol
    Monoisotopic Mass196.0767261 g/mol
    Topological Polar Surface Area15.3 Ų
    Heavy Atom Count13
    Formal Charge0
    Complexity157
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Serotonin Receptor Agonists

    Endogenous compounds and drugs that bind to and activate SEROTONIN RECEPTORS. Many serotonin receptor agonists are used as ANTIDEPRESSANTS; ANXIOLYTICS; and in the treatment of MIGRAINE DISORDERS. (See all compounds classified as Serotonin Receptor Agonists.)

    4.2 Metabolism/Metabolites

    1-(3-Chlorophenyl)piperazine has known human metabolites that include 2-chloro-4-(piperazin-1-yl)phenol.

    1-(3-Chlorophenyl)piperazine is a known human metabolite of etoperidone, nefazodone, and trazodone.

    S73 | METXBIODB | Metabolite Reaction Database from BioTransformer | DOI:10.5281/zenodo.4056560

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                                  Nefazodone
                                  Maisuriya Pharma Solutions is a research-driven & technology-oriented company. Continuous innovations & i...
                                  Maisuriya Pharma Solutions is a research-driven & technology-oriented company. Continuous innovations & improvement are the lifeblood of our business. Our major focus is to offer pharmaceutical solutions globally. Our core expertise: Development of processes and production of complex molecules for Lifesciences and Specialty Chemicals markets. We are committed to providing customers with products fulfilling customers’ needs and expectations. Maisuriya Pharma Solutions ensures Safety and Reliability with respect to regulations (sustainable development, ISO, GMP), and guarantees total confidentiality.
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                                  Maisuriya Pharma Solutions

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                                    Bis(2-chloroethyl)amine Hydrochloride

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                                    821-48-7
                                    Trazodone Hydrochloride
                                    Maisuriya Pharma Solutions is a research-driven & technology-oriented company. Continuous innovations & i...
                                    Maisuriya Pharma Solutions is a research-driven & technology-oriented company. Continuous innovations & improvement are the lifeblood of our business. Our major focus is to offer pharmaceutical solutions globally. Our core expertise: Development of processes and production of complex molecules for Lifesciences and Specialty Chemicals markets. We are committed to providing customers with products fulfilling customers’ needs and expectations. Maisuriya Pharma Solutions ensures Safety and Reliability with respect to regulations (sustainable development, ISO, GMP), and guarantees total confidentiality.
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                                    Medilux Laboratories

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                                      1-(3-Chlorophenyl)-4-(3-chloropropyl) piperazine hydroc...

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                                      52605-52-4
                                      Trazodone Hydrochloride
                                      Medilux Laboratories has been providing quality back-end support to the pharmaceutical industry at large ...
                                      Medilux Laboratories has been providing quality back-end support to the pharmaceutical industry at large since our inception in 1988. Our resources are dedicated to promoting better health through products that offer superior value. Located at Pithampur, Madhya Pradesh, Medilux Laboratories has been committed to strategic research, delivering a complex range of chemistries that are globally benchmarked. Our products and services are rapidly making strides in the global pharmaceutical space, giving us the impetus to constantly strive for excellence in addition to providing quality customer service. Supported by a workforce of over 150 dedicate
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                                        1-(3-Chlorophenyl)piperazine hydrochloride

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                                        65369-76-8
                                        Cloperidone Hydrochloride
                                        Medilux Laboratories has been providing quality back-end support to the pharmaceutical industry at large ...
                                        Medilux Laboratories has been providing quality back-end support to the pharmaceutical industry at large since our inception in 1988. Our resources are dedicated to promoting better health through products that offer superior value. Located at Pithampur, Madhya Pradesh, Medilux Laboratories has been committed to strategic research, delivering a complex range of chemistries that are globally benchmarked. Our products and services are rapidly making strides in the global pharmaceutical space, giving us the impetus to constantly strive for excellence in addition to providing quality customer service. Supported by a workforce of over 150 dedicate
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                                          1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one

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                                          6969-71-7
                                          Trazodone Hydrochloride
                                          Medilux Laboratories has been providing quality back-end support to the pharmaceutical industry at large ...
                                          Medilux Laboratories has been providing quality back-end support to the pharmaceutical industry at large since our inception in 1988. Our resources are dedicated to promoting better health through products that offer superior value. Located at Pithampur, Madhya Pradesh, Medilux Laboratories has been committed to strategic research, delivering a complex range of chemistries that are globally benchmarked. Our products and services are rapidly making strides in the global pharmaceutical space, giving us the impetus to constantly strive for excellence in addition to providing quality customer service. Supported by a workforce of over 150 dedicate
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                                            1-(3-Chlorophenyl)piperazine hydrochloride

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                                            65369-76-8
                                            Etretinate
                                            Medilux Laboratories has been providing quality back-end support to the pharmaceutical industry at large ...
                                            Medilux Laboratories has been providing quality back-end support to the pharmaceutical industry at large since our inception in 1988. Our resources are dedicated to promoting better health through products that offer superior value. Located at Pithampur, Madhya Pradesh, Medilux Laboratories has been committed to strategic research, delivering a complex range of chemistries that are globally benchmarked. Our products and services are rapidly making strides in the global pharmaceutical space, giving us the impetus to constantly strive for excellence in addition to providing quality customer service. Supported by a workforce of over 150 dedicate
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                                            Medilux Laboratories

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                                              1-(3-Chlorophenyl)piperazine hydrochloride

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                                              65369-76-8
                                              Trazodone Hydrochloride
                                              Medilux Laboratories has been providing quality back-end support to the pharmaceutical industry at large ...
                                              Medilux Laboratories has been providing quality back-end support to the pharmaceutical industry at large since our inception in 1988. Our resources are dedicated to promoting better health through products that offer superior value. Located at Pithampur, Madhya Pradesh, Medilux Laboratories has been committed to strategic research, delivering a complex range of chemistries that are globally benchmarked. Our products and services are rapidly making strides in the global pharmaceutical space, giving us the impetus to constantly strive for excellence in addition to providing quality customer service. Supported by a workforce of over 150 dedicate
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                                                1-(3-Chlorophenyl)-4-(3-chloropropyl) piperazine hydroc...

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                                                52605-52-4
                                                Etoperidone
                                                Medilux Laboratories has been providing quality back-end support to the pharmaceutical industry at large ...
                                                Medilux Laboratories has been providing quality back-end support to the pharmaceutical industry at large since our inception in 1988. Our resources are dedicated to promoting better health through products that offer superior value. Located at Pithampur, Madhya Pradesh, Medilux Laboratories has been committed to strategic research, delivering a complex range of chemistries that are globally benchmarked. Our products and services are rapidly making strides in the global pharmaceutical space, giving us the impetus to constantly strive for excellence in addition to providing quality customer service. Supported by a workforce of over 150 dedicate
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                                                Medilux Laboratories

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                                                  1-(3-Chlorophenyl)-4-(3-chloropropyl) piperazine hydroc...

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                                                  52605-52-4
                                                  Nefazodone
                                                  Medilux Laboratories has been providing quality back-end support to the pharmaceutical industry at large ...
                                                  Medilux Laboratories has been providing quality back-end support to the pharmaceutical industry at large since our inception in 1988. Our resources are dedicated to promoting better health through products that offer superior value. Located at Pithampur, Madhya Pradesh, Medilux Laboratories has been committed to strategic research, delivering a complex range of chemistries that are globally benchmarked. Our products and services are rapidly making strides in the global pharmaceutical space, giving us the impetus to constantly strive for excellence in addition to providing quality customer service. Supported by a workforce of over 150 dedicate
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                                                  Prajna Generics

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                                                    2-{3-[4-(3-Chlorophenyl)piperazin-1-yl]propyl} [1,2,4]t...

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                                                    19794-93-5
                                                    Trazodone Hydrochloride
                                                    Prajna is an innovation driven pharmaceutical company. We dedicated to Research, Process development and ...
                                                    Prajna is an innovation driven pharmaceutical company. We dedicated to Research, Process development and Manufacturing APIs and Advanced Intermediates for Active Pharmaceutical Ingredients (APIs) for the global pharmaceutical companies. It provides value-added services in Contract Research, Custom Synthesis, and Specialties Scientific technology (Green Process, APIs Process Development, Polymorphism, Crystallisation and Purification) for Pharmaceutical and Life Sciences industry.
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                                                    Riddhesh Pharmachem

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                                                      1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one

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                                                      6969-71-7
                                                      Trazodone Hydrochloride
                                                      Riddhesh Pharmachem is a contract research and contract manufacturer from India. It has developed a servi...
                                                      Riddhesh Pharmachem is a contract research and contract manufacturer from India. It has developed a service-oriented system that has allowed it to become a leading manufacturer and supplier of raw materials for Pharmaceutical and Chemical companies globally and regionally. During a very successful period of business incubation within the Group, Riddhesh Pharmachem has developed its substantial sector-specific expertise and established its reputation. The business has moved into the global market and integrated into worldwide manufacturers and suppliers which are looking to contract manufacturers or suppliers from India.
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                                                      Shivam Petrochem Industries

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                                                        3-Chloro-Phenylpiperazine

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                                                        13078-15-4
                                                        Trazodone Hydrochloride
                                                        Shivam Petrochem Industries was founded with the aim of meeting the needs of pharmaceutical companies by ...
                                                        Shivam Petrochem Industries was founded with the aim of meeting the needs of pharmaceutical companies by offering tailored solutions. As an ISO 9001:2015 certified company, we strictly adhere to GMP guidelines in the production of pharmaceutical intermediates. Our commitment to rigorous policies, values, and regulatory standards ensures top-notch quality, punctual delivery, and customer contentment.
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                                                        SPC Lifesciences Pvt. Ltd

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                                                          1-(3-Chlorophenyl)-4-(3-chloropropyl) piperazine HCl

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                                                          52605-52-4
                                                          Trazodone Hydrochloride
                                                          Established in 2006, SPC Lifesciences is a truly knowledge driven and fully integrated pharmaceutical com...
                                                          Established in 2006, SPC Lifesciences is a truly knowledge driven and fully integrated pharmaceutical company creating global solutions. We are a dynamic chemical synthesis company associated with the pharmaceutical and life sciences industry. For projects that involve complex chemistry and technological excellence & Import substitutes, we have a team that has a proven track record delivering - every time. We are the leading manufacturer & exporter of a broad range of pharmaceutical active ingredients and intermediates which are extensively used in various finished doses & research laboratories.
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                                                            1,2,4-Triazolo (4,3-a) Pyridine-3-(2H)-One

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                                                            6969-71-7
                                                            Trazodone Hydrochloride
                                                            Established in 2006, SPC Lifesciences is a truly knowledge driven and fully integrated pharmaceutical com...
                                                            Established in 2006, SPC Lifesciences is a truly knowledge driven and fully integrated pharmaceutical company creating global solutions. We are a dynamic chemical synthesis company associated with the pharmaceutical and life sciences industry. For projects that involve complex chemistry and technological excellence & Import substitutes, we have a team that has a proven track record delivering - every time. We are the leading manufacturer & exporter of a broad range of pharmaceutical active ingredients and intermediates which are extensively used in various finished doses & research laboratories.
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                                                            SPC Lifesciences Pvt. Ltd

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                                                              1-(3-Chlorophenyl)-4-(3-chloropropyl) piperazine HCl

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                                                              52605-52-4
                                                              Etoperidone
                                                              Established in 2006, SPC Lifesciences is a truly knowledge driven and fully integrated pharmaceutical com...
                                                              Established in 2006, SPC Lifesciences is a truly knowledge driven and fully integrated pharmaceutical company creating global solutions. We are a dynamic chemical synthesis company associated with the pharmaceutical and life sciences industry. For projects that involve complex chemistry and technological excellence & Import substitutes, we have a team that has a proven track record delivering - every time. We are the leading manufacturer & exporter of a broad range of pharmaceutical active ingredients and intermediates which are extensively used in various finished doses & research laboratories.
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                                                              SPC Lifesciences Pvt. Ltd

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                                                                Bis (2-chloroethyl) amine HCl

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                                                                821-48-7
                                                                Trazodone Hydrochloride
                                                                Established in 2006, SPC Lifesciences is a truly knowledge driven and fully integrated pharmaceutical com...
                                                                Established in 2006, SPC Lifesciences is a truly knowledge driven and fully integrated pharmaceutical company creating global solutions. We are a dynamic chemical synthesis company associated with the pharmaceutical and life sciences industry. For projects that involve complex chemistry and technological excellence & Import substitutes, we have a team that has a proven track record delivering - every time. We are the leading manufacturer & exporter of a broad range of pharmaceutical active ingredients and intermediates which are extensively used in various finished doses & research laboratories.
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                                                                SPC Lifesciences Pvt. Ltd

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                                                                  1-(3-Chlorophenyl)-4-(3-chloropropyl) piperazine HCl

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                                                                  52605-52-4
                                                                  Nefazodone
                                                                  Established in 2006, SPC Lifesciences is a truly knowledge driven and fully integrated pharmaceutical com...
                                                                  Established in 2006, SPC Lifesciences is a truly knowledge driven and fully integrated pharmaceutical company creating global solutions. We are a dynamic chemical synthesis company associated with the pharmaceutical and life sciences industry. For projects that involve complex chemistry and technological excellence & Import substitutes, we have a team that has a proven track record delivering - every time. We are the leading manufacturer & exporter of a broad range of pharmaceutical active ingredients and intermediates which are extensively used in various finished doses & research laboratories.
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                                                                  fermion-oy-2024-05-13

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                                                                  Inke S.A: APIs manufacturing plant.

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