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CAS 144689-63-4
PharmaCompass
CAS 144689-63-4
Also known as: 144689-63-4, Benicar, Olmetec, Cs-866, Cs 866, Olmesartan (medoxomil)
Molecular Formula
C29H30N6O6
Molecular Weight
558.595  g/mol
InChI Key
UQGKUQLKSCSZGY-UHFFFAOYSA-N
FDA UNII
6M97XTV3HD

An ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKER that is used to manage HYPERTENSION.
1 2D Structure

CAS 144689-63-4

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 5-(2-hydroxypropan-2-yl)-2-propyl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazole-4-carboxylate
2.1.2 InChI
InChI=1S/C29H30N6O6/c1-5-8-23-30-25(29(3,4)38)24(27(36)39-16-22-17(2)40-28(37)41-22)35(23)15-18-11-13-19(14-12-18)20-9-6-7-10-21(20)26-31-33-34-32-26/h6-7,9-14,38H,5,8,15-16H2,1-4H3,(H,31,32,33,34)
2.1.3 InChI Key
UQGKUQLKSCSZGY-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CCCC1=NC(=C(N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NNN=N4)C(=O)OCC5=C(OC(=O)O5)C)C(C)(C)O
2.2 Other Identifiers
2.2.1 UNII
6M97XTV3HD
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. 144689-63-4

2. Benicar

3. Olmetec

4. Cs-866

5. Cs 866

6. Olmesartan (medoxomil)

7. Benevas

8. Olvance

9. Unii-6m97xtv3hd

10. Olmesartan Medoximil

11. Benicar (tn)

12. Olmetec (tn)

13. Ks-1182

14. 6m97xtv3hd

15. Benicar Hct

16. Cs-866dm

17. Cs-866rn

18. C29h30n6o6

19. De-092

20. Ncgc00095136-01

21. (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 5-(2-hydroxypropan-2-yl)-2-propyl-3-[[4-[2-(2h-tetrazol-5-yl)phenyl]phenyl]methyl]imidazole-4-carboxylate

22. 1h-imidazole-5-carboxylic Acid, 4-(1-hydroxy-1-methylethyl)-2-propyl-1-((2'-(1h-tetrazol-5-yl) (1,1'-biphenyl)-4-yl)methyl)-, (5-methyl-2-oxo-1,3-dioxol-4-yl) Methyl Ester

23. 1h-imidazole-5-carboxylic Acid, 4-(1-hydroxy-1-methylethyl)-2-propyl-1-((2'-(1h-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)-, (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl Ester

24. Olsertain

25. (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 1-((2'-(1h-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-4-(2-hydroxypropan-2-yl)-2-propyl-1h-imidazole-5-carboxylate

26. (5-methyl-2-oxo-2h-1,3-dioxol-4-yl)methyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-({4-[2-(1h-1,2,3,4-tetrazol-5-yl)phenyl]phenyl}methyl)-1h-imidazole-5-carboxylate

27. 1h-imidazole-5-carboxylic Acid, 4-(1-hydroxy-1-methylethyl)-2-propyl-1-((2'-(1h-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)-,(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl Ester

28. 5-(2-hydroxypropan-2-yl)-2-propyl-3-[[4-[2-(2h-tetrazol-5-yl)phenyl]phenyl]methyl]-4-imidazolecarboxylic Acid (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl Ester

29. Votume

30. Openvas

31. Olmesartanmedoxomil

32. (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 5-(2-hydroxypropan-2-yl)-2-propyl-3-[[4-[2-(1h-tetrazol-5-yl)phenyl]phenyl]methyl]imidazole-4-carboxylate

33. Olmesartan Medoxomil [usan:inn:ban]

34. Spectrum_001944

35. Spectrum2_000506

36. Spectrum3_001676

37. Spectrum4_000740

38. Spectrum5_001556

39. D07ubg

40. Benicar, Olmetec,olmesartan

41. Dsstox_cid_25924

42. Dsstox_rid_81226

43. Dsstox_gsid_45924

44. Schembl16403

45. Bspbio_003491

46. Gtpl591

47. Kbiogr_001040

48. Kbioss_002498

49. Mls006010109

50. Bio-0071

51. Spectrum1505205

52. Spbio_000431

53. Olmesartan Medoxomil (benicar)

54. Ac1l2y71

55. Chembl1200692

56. Dtxsid9045924

57. Chebi:31932

58. Chebi:93384

59. Kbio2_002490

60. Kbio2_005058

61. Kbio2_007626

62. Kbio3_002711

63. Ks-00000ivq

64. Aob3863

65. Olmesartan Medoxomil (jan/usan)

66. Uqgkuqlkscszgy-uhfffaoysa-n

67. Cs866

68. Hms1922l15

69. Hms2089k18

70. Hms2093k16

71. Hms3651e13

72. Pharmakon1600-01505205

73. Ebd35964

74. Olmesartan Medoxomil (jp17/usan)

75. Zinc4149248

76. Tox21_111445

77. Bdbm50442892

78. Ccg-39596

79. Forest Brand Of Olmesartan Medoxomil

80. Mfcd00944911

81. Nsc758924

82. Olmesartan Medoxomil Tablets (jp17)

83. S1604

84. Sankyo Brand Of Olmesartan Medoxomil

85. Stl451024

86. Akos015894907

87. Akos015914772

88. Ac-1601

89. An-1125

90. Bcp9000555

91. Ccg-221184

92. Cs-0577

93. Mcule-2480015750

94. Nsc-758924

95. Olmesartan Medoxomil, >=98% (hplc)

96. Rp17784

97. Ncgc00095136-02

98. Ncgc00095136-03

99. (5-methyl-2-oxo-1,3-dioxolen-4-yl)methoxy-4-(1-hydroxy-1-methylethyl)-2-propyl-1-(4-(2-(tetrazol-5-yl)phenyl)phenyl)methylimidazol-5-carboxylate

100. Ak-72894

101. Bc208264

102. Bc209016

103. Br-72894

104. Cpd004727564

105. Dr003267

106. He311789

107. Hy-17005

108. Nu006784

109. Sam001246634

110. Sc-17112

111. Smr002203616

112. Sbi-0206741.p001

113. Ab0012006

114. Ab1009487

115. Berlin-chemie Brand Of Olmesartan Medoxomil

116. Ls-181818

117. Cas-144689-63-4

118. Ft-0601603

119. O0510

120. St24031498

121. D01204

122. J10058

123. S-1787

124. Ab01275443-01

125. Ab01275443_02

126. Ab01275443_03

127. 689o634

128. A808260

129. L001061

130. Sr-05000001987

131. I06-0025

132. J-501595

133. Sr-05000001987-2

134. Brd-k78485176-001-02-9

135. I14-41691

136. Z1550675457

137. Olmesartan Medoxomil, European Pharmacopoeia (ep) Reference Standard

138. Olmesartan Medoxomil, United States Pharmacopeia (usp) Reference Standard

139. Olmesartan Medoxomil For System Suitability, European Pharmacopoeia (ep) Reference Standard

140. Olmesartan Medoxomil, Pharmaceutical Secondary Standard; Certified Reference Material

141. (5-methyl-2-oxidanylidene-1,3-dioxol-4-yl)methyl 5-(2-oxidanylpropan-2-yl)-2-propyl-3-[[4-[2-(2h-1,2,3,4-tetrazol-5-yl)phenyl]phenyl]methyl]imidazole-4-carboxylate

142. (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 1-((2'-(1h-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-4-(2-h

143. (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 1-((2'-(1h-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-4-(2-hydroxypropan-2-yl)-2-propyl-1h-i Midazole-5-carboxylate

144. (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 1-((2'-(1h-tetrazol-5-yl)-[1,1'-biphenyl]4-yl)methyl)-4-(2-hydroxypropan-2-yl)-2-propyl-1h-imidazole-5-carboxylate

145. (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 1-((2'-(2h-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-4-(2-hydroxypropan-2-yl)-2-propyl-1h-imidazole-5-carboxylate

146. (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 1-((2'-(2h-tetrazol-5-yl)biphenyl-4-yl)methyl)-4-(2-hydroxypropan-2-yl)-2-propyl-1h-imidazole-5-carboxylate

147. (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 1-[[2'-(1h-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]methyl]-4-(2-hydroxypr

148. (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-(2-hydroxy-2-propanyl)-2-propyl-1-[[2'-(1h-tetrazol-5-yl)-4-biphenylyl]methyl]-1h-imidazole-5-carboxylate

149. (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-{[2'-(1h-tetrazol-5-yl)biphenyl-4-yl]methyl}-1h-imidazole-5-carboxylate

150. (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 5-(1-hydroxy-1-methyl-ethyl)-2-propyl-3-[[4-[2-(2h-tetrazol-5-yl)phenyl]phenyl]methyl]imidazole-4-carboxylate

151. (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 5-(2-hydroxypropan-2-yl)-2-propyl-3-({4-[2-(2h-1,2,3,4-tetrazol-5-yl)phenyl]phenyl}methyl)imidazole-4-carboxylate

152. (5-methyl-2-oxo-1,3-dioxolen-4-yl)methyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[[2'-(1h-tetrazol-5-yl)biphenyl-4-yl]methyl]imidazole-5-carboxylate

153. (5-methyl-2-oxo-1,3-dioxolen-4-yl)methyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1-{4-[2-(tetrazol-5-yl)phenyl]phenyl}methylimidazole-5-carboxylate

154. (5-methyl-2-oxo-1,3-dioxolen-4-yl)methyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1-{4-[2-(tetrazol-5-yl)phenyl]phenylmethyl}imidazol-5-carboxylate;

155. (5-methyl-2-oxo-1,3-dioxolen-4yl)methyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1-{4-[2-(tetrazol-5-yl)phenyl]phenyl}methylimidazole-5-carboxylate

156. (5-methyl-2-oxo-2h-1,3-dioxol-4-yl)methyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-{[2'-(1h-1,2,3,4-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]methyl}-1h-imidazole-5-carboxylate

157. 5-(1-hydroxy-1-methyl-ethyl)-2-propyl-3-[2'-(1h-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3h-imidazole-4-carboxylic Acid 5-methyl-2-oxo-[1,3]dioxol-4-ylmethyl Ester

158. 5-(1-hydroxy-1-methylethyl)-2-propyl-3-[2'-(1h-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3h-imidazole-4-carboxylic Acid 5-methyl-2-oxo-[1,3]dioxol-4-ylmethyl Ester

159. Olmesartan Medoxomil

160. 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[[2'-(2h-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1h-imidazole-5-carboxylic Acid-(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl Ester

161. Olmetec; 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[[2'-(1htetazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1h-imidazole-5-carboxylic Acid (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl Ester

2.4 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 558.595 g/mol
Molecular Formula C29H30N6O6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count10
Rotatable Bond Count11
Exact Mass558.223 g/mol
Monoisotopic Mass558.223 g/mol
Topological Polar Surface Area154 A^2
Heavy Atom Count41
Formal Charge0
Complexity969
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Information
1 of 8  
Drug NameOLMESARTAN MEDOXOMIL
Active IngredientOLMESARTAN MEDOXOMIL
CompanyACCORD HLTHCARE (Application Number: A207662); ALEMBIC PHARMS LTD (Application Number: A203012); ALKEM LABS LTD (Application Number: A206763); AUROBINDO PHARMA LTD (Application Number: A204798); GLENMARK PHARMS LTD (Application Number: A203281); JUBILANT GENERICS (Application Number: A205482); LUPIN LTD (Application Number: A206631); MACLEODS PHARMS LTD (Application Number: A204814); MYLAN PHARMS INC (Application Number: A078276); TEVA PHARMS USA (Application Number: A091079); TORRENT PHARMS LTD (Application Number: A202375); ZYDUS PHARMS USA INC (Application Number: A205192)

2 of 8  
Drug NameAZOR
Active IngredientAMLODIPINE BESYLATE; OLMESARTAN MEDOXOMIL
CompanyDAIICHI SANKYO (Application Number: N022100)

3 of 8  
Drug NameBENICAR HCT
Active IngredientHYDROCHLOROTHIAZIDE; OLMESARTAN MEDOXOMIL
CompanyDAIICHI SANKYO (Application Number: N021532)

4 of 8  
Drug NameTRIBENZOR
Active IngredientAMLODIPINE BESYLATE; HYDROCHLOROTHIAZIDE; OLMESARTAN MEDOXOMIL
CompanyDAIICHI SANKYO (Application Number: N200175)

5 of 8  
Drug NameBENICAR
Active IngredientOLMESARTAN MEDOXOMIL
CompanyDAIICHI SANKYO (Application Number: N021286)

6 of 8  
Drug NameAMLODIPINE AND OLMESARTAN MEDOXOMIL
Active IngredientAMLODIPINE BESYLATE; OLMESARTAN MEDOXOMIL
CompanyAJANTA PHARMA LTD (Application Number: A207216); ALEMBIC PHARMS LTD (Application Number: A207073); ALKEM LABS LTD (Application Number: A209042); AUROBINDO PHARMA LTD (Application Number: A206906); GLENMARK PHARMS LTD (Application Number: A207807); JUBILANT GENERICS (Application Number: A207450); MACLEODS PHARMS LTD (Application Number: A206884); MICRO LABS (Application Number: A207435); TEVA PHARMS USA (Application Number: A091154); TORRENT PHARMS LTD (Application Number: A202933); ZYDUS PHARMS USA INC (Application Number: A207771)

7 of 8  
Drug NameOLMESARTAN MEDOXOMIL AND HYDROCHLOROTHIAZIDE
Active IngredientHYDROCHLOROTHIAZIDE; OLMESARTAN MEDOXOMIL
CompanyALEMBIC PHARMS LTD (Application Number: A204233); AUROBINDO PHARMA LTD (Application Number: A205391); MYLAN PHARMS INC (Application Number: A078827); PRINSTON INC (Application Number: A207804); TEVA PHARMS USA (Application Number: A200532); TORRENT PHARMS LTD (Application Number: A206515)

8 of 8  
Drug NameOLMESARTAN MEDOXOMIL, AMLODIPINE AND HYDROCHLOROTHIAZIDE
Active IngredientAMLODIPINE BESYLATE; HYDROCHLOROTHIAZIDE; OLMESARTAN MEDOXOMIL
CompanyPAR PHARM INC (Application Number: A206137); TEVA PHARMS USA (Application Number: A202491); TORRENT PHARMS LTD (Application Number: A203580)

5 Pharmacology and Biochemistry
5.1 Pharmacology

Olmesartan Medoxomil is a synthetic imidazole derivative prodrug with an antihypertensive property. Upon hydrolysis, olmesartan medoxomil is converted to olmesartan. Olmesartan selectively binds to the angiotensin type 1 (AT1) receptor of angiotensin II in vascular smooth muscle and adrenal gland, thereby competing angiotensin II binding to the receptor. This prevents angiotensin II-induced vasoconstriction and decreases aldosterone production, thereby preventing aldosterone-stimulated sodium retention and potassium excretion.


5.2 MeSH Pharmacological Classification

Angiotensin II Type 1 Receptor Blockers

Agents that antagonize ANGIOTENSIN II TYPE 1 RECEPTOR. Included are ANGIOTENSIN II analogs such as SARALASIN and biphenylimidazoles such as LOSARTAN. Some are used as ANTIHYPERTENSIVE AGENTS.


Antihypertensive Agents

Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.


5.3 ATC Code

C - Cardiovascular system
C09 - Agents acting on the renin-angiotensin system
C09C - Angiotensin ii antagonists, plain
C09CA - Angiotensin ii antagonists, plain
C09CA08 - Olmesartan medoxomil


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