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CAS 115436-72-1
PharmaCompass
CAS 115436-72-1
Also known as: Sodium risedronate, Actonel, 115436-72-1, Unii-ofg5exg60l, Risedronic acid monosodium salt, Ne 58095
Molecular Formula
C7H10NNaO7P2
Molecular Weight
305.094  g/mol
InChI Key
DRFDPXKCEWYIAW-UHFFFAOYSA-M
FDA UNII
OFG5EXG60L

An aminobisphosphonate derivative of etidronic acid and CALCIUM CHANNEL BLOCKER that inhibits BONE RESORPTION and is used for the treatment of OSTEOPOROSIS.
1 2D Structure

CAS 115436-72-1

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
sodium;hydroxy-(1-hydroxy-1-phosphono-2-pyridin-3-ylethyl)phosphinate
2.1.2 InChI
InChI=1S/C7H11NO7P2.Na/c9-7(16(10,11)12,17(13,14)15)4-6-2-1-3-8-5-6;/h1-3,5,9H,4H2,(H2,10,11,12)(H2,13,14,15);/q;+1/p-1
2.1.3 InChI Key
DRFDPXKCEWYIAW-UHFFFAOYSA-M
2.1.4 Canonical SMILES
C1=CC(=CN=C1)CC(O)(P(=O)(O)O)P(=O)(O)[O-].[Na+]
2.2 Other Identifiers
2.2.1 UNII
OFG5EXG60L
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. Sodium Risedronate

2. Actonel

3. 115436-72-1

4. Unii-ofg5exg60l

5. Risedronic Acid Monosodium Salt

6. Ne 58095

7. Risedronic Acid Sodium Salt

8. C7h10nnao7p2

9. Monosodium (1-hydroxy-2-(3-pyridinyl)ethylidene)bisphosphonate

10. Sodium Trihydrogen (1-hydroxy-2-(3-pyridyl)ethylidene)diphosphonate

11. Risedronate (sodium)

12. Q-201723

13. Risedremate Sodium

14. Phosphonic Acid, (1-hydroxy-2-(3-pyridinyl)ethylidene)bis-, Monosodium Salt

15. Monosodium Risedronate Hemipentahydrate

16. Risedronate Sodium [usan]

17. C7h10no7p2.na

18. Optinate

19. Risedronic Acid Sodium

20. Acrel

21. Risedronate Sodium [usan:usp]

22. Optinate Septimum

23. Monosodium Risedronate

24. Risedronate Na

25. Risedronate Sodium Salt

26. Ofg5exg60l

27. Risedronate Sodium (usp)

28. Ac1q1vb7

29. Chembl1654

30. Schembl18377

31. Ac1n5g27

32. Chebi:8868

33. Risedronic Acid, Monosodium Salt

34. Ctk8f0842

35. Drfdpxkcewyiaw-uhfffaoysa-m

36. Bb_sc-1157

37. Act03362

38. Risedronic Acid, Sodium Salt

39. 105462-24-6 (parent)

40. Ac-732

41. Cs0033

42. Mfcd00867080

43. Mfcd01706268

44. S1428

45. Akos015833432

46. Ab09807

47. Api0004080

48. Ccg-213235

49. Rtc-070962

50. Ncgc00346521-01

51. Ac-20120

52. An-15580

53. As-13309

54. Cpd000469279

55. H864

56. He298537

57. Sam001246537

58. Ab2000101

59. Ls-106650

60. Tc-070962

61. Ft-0631078

62. M2289

63. D00942

64. J10129

65. K-1095

66. Ab01274790-01

67. I02-0324

68. 2-(3-pyridinyl)-2-hydroxyethylidene-1,1-bisphosphonate

69. Monosodium 1-hydroxy-2-(3-pyridyl)ethylidene-1,1-diphosphonate

70. (1-hydroxy-2-(3-pyridinyl)ethylidene)-bis(phosphonic Acid) Monosodium Salt

71. [1-hydroxy-2-(3-pyridinyl)ethylidene]bisphosphonic Acid Monosodium Salt

72. 1-hydroxy-2-(3-pyridinyl) Ethylidene Bis-phosphonic Acid Monosodium Salt

73. Hydrogen [1-hydroxy-1-phosphono-2-(pyridin-3-yl)ethyl]phosphonate (na+)

74. P,p'-[1-hydroxy-2-(3-pyridonyl)ethylidene]bis-phosphonic Acid Sodium Salt

75. Phosphonic Acid, (1-hydroxy-2-(3-pyridinyl)ethylidene)bis-, Disodium Salt

76. Phosphonic Acid, (2-hydroxy-2-(3-pyridinyl)ethylidene)bis-, Disodium Salt

77. Sodium Hydrogen (1-hydroxy-1-phosphono-2-(pyridin-3-yl)ethyl)phosphonate

78. Sodium Hydrogen(1-hydroxy-1-phosphono-2-(pyridin-3-yl)ethyl)phosphonate

79. Sodium Hydroxy-(1-hydroxy-1-phosphono-2-pyridin-3-ylethyl)phosphinate

80. Sodium Hydroxy-[1-hydroxy-1-phosphono-2-(3-pyridyl)ethyl]phosphinate

81. 1-hydroxy-1-[hydroxy(sodiooxy)phosphoryl]-2-(pyridin-3-yl)ethylphosphonic Acid

82. Sodium Hydroxy-1-hydroxy-1-phosphono-2-(pyridin-3-yl)ethylphosphinate

83. 122458-82-6

84. 934544-85-1

2.4 Create Date
2005-09-13
3 Chemical and Physical Properties
Molecular Weight 305.094 g/mol
Molecular Formula C7H10NNaO7P2
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count8
Rotatable Bond Count4
Exact Mass304.983 g/mol
Monoisotopic Mass304.983 g/mol
Topological Polar Surface Area151 A^2
Heavy Atom Count18
Formal Charge0
Complexity375
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Drug Information
1 of 3  
Drug NameACTONEL
Active IngredientRISEDRONATE SODIUM
CompanyAPIL (Application Number: N020835. Patents: 5994329, 5994329*PED, 6015801, 6015801*PED, 6165513, 6165513*PED, 6432932, 6432932*PED, 6465443, 6465443*PED, 7192938, 7192938*PED, 7718634, 7718634*PED)

2 of 3  
Drug NameATELVIA
Active IngredientRISEDRONATE SODIUM
CompanyAPIL (Application Number: N022560. Patents: 7645459, 7645460, 8246989)

3 of 3  
Drug NameRISEDRONATE SODIUM
Active IngredientRISEDRONATE SODIUM
CompanyAPOTEX INC (Application Number: A090877); AUROBINDO PHARMA LTD (Application Number: A200296); AUROBINDO PHARMA LTD (Application Number: A206768); MACLEODS PHARMS LTD (Application Number: A203533); MYLAN PHARMS INC (Application Number: A200477); SUN PHARMA GLOBAL (Application Number: A090886); TEVA PHARMS USA (Application Number: A077132); TEVA PHARMS USA (Application Number: A079215); TEVA PHARMS USA (Application Number: A203217)

4.2 Drug Indication

Treatment of postmenopausal osteoporosis, to reduce the risk of vertebral fractures and the treatment of established postmenopausal osteoporosis, to reduce the risk of hip fractures


5 Pharmacology and Biochemistry
5.1 Pharmacology

Risedronate Sodium is the sodium salt of risedronic acid, a synthetic pyridinyl bisphosphonate. Risedronic acid binds to hydroxyapatite crystals in bone and inhibits osteoclast-dependent bone resorption.


5.2 MeSH Pharmacological Classification

Bone Density Conservation Agents

Agents that inhibit BONE RESORPTION and/or favor BONE MINERALIZATION and BONE REGENERATION. They are used to heal BONE FRACTURES and to treat METABOLIC BONE DISEASES such as OSTEOPOROSIS.


Calcium Channel Blockers

A class of drugs that act by selective inhibition of calcium influx through cellular membranes.


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