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Chemistry

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Also known as: Sodium risedronate, 115436-72-1, Actonel, Atelvia, Risedronate (sodium), Ne 58095
Molecular Formula
C7H10NNaO7P2
Molecular Weight
305.09  g/mol
InChI Key
DRFDPXKCEWYIAW-UHFFFAOYSA-M
FDA UNII
OFG5EXG60L

Risedronate Sodium
A pyridine and diphosphonic acid derivative that acts as a CALCIUM CHANNEL BLOCKER and inhibits BONE RESORPTION.
1 2D Structure

Risedronate Sodium

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
sodium;hydroxy-(1-hydroxy-1-phosphono-2-pyridin-3-ylethyl)phosphinate
2.1.2 InChI
InChI=1S/C7H11NO7P2.Na/c9-7(16(10,11)12,17(13,14)15)4-6-2-1-3-8-5-6;/h1-3,5,9H,4H2,(H2,10,11,12)(H2,13,14,15);/q;+1/p-1
2.1.3 InChI Key
DRFDPXKCEWYIAW-UHFFFAOYSA-M
2.1.4 Canonical SMILES
C1=CC(=CN=C1)CC(O)(P(=O)(O)O)P(=O)(O)[O-].[Na+]
2.2 Other Identifiers
2.2.1 UNII
OFG5EXG60L
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 1-hydroxy-2-(3-pyridyl)ethylidene Diphosphonate

2. 2-(3-pyridinyl)-1-hydroxyethylidene-bisphosphonate

3. 2-(3-pyridinyl)-1-hydroxyethylidenebisphosphonate

4. Actonel

5. Atelvia

6. Bisphosphonate Risedronate Sodium

7. Risedronate

8. Risedronate Sodium, Bisphosphonate

9. Risedronic Acid

10. Risedronic Acid, Monosodium Salt

11. Sodium, Bisphosphonate Risedronate

2.3.2 Depositor-Supplied Synonyms

1. Sodium Risedronate

2. 115436-72-1

3. Actonel

4. Atelvia

5. Risedronate (sodium)

6. Ne 58095

7. Risedronic Acid Monosodium Salt

8. Risedronate Monosodium

9. Ofg5exg60l

10. Risedronate Sodium Anhydrous

11. Ne-58095 Anhydrous

12. Sodium Trihydrogen (1-hydroxy-2-(3-pyridyl)ethylidene)diphosphonate

13. 115436-72-1 (sodium)

14. Risedronic Acid Sodium

15. Benet

16. Nsc-722598

17. Nsc-759280

18. Actonel (tn)

19. Phosphonic Acid, (1-hydroxy-2-(3-pyridinyl)ethylidene)bis-, Monosodium Salt

20. Sodium Hydrogen (1-hydroxy-1-phosphono-2-(pyridin-3-yl)ethyl)phosphonate

21. Risedronate Sodium [usan]

22. Risedronic Acid Sodium Salt

23. Mfcd00867080

24. 122458-82-6

25. Unii-ofg5exg60l

26. Optinate

27. Acrel

28. Risedronate Sodium [usan:usp]

29. Sodium Hydrogen [1-hydroxy-1-phosphono-2-(pyridin-3-yl)ethyl]phosphonate

30. Optinate Septimum

31. Monosodium Risedronate

32. Monosodium (1-hydroxy-2-(3-pyridinyl)ethylidene)bisphosphonate

33. Ne 58095 Sodium

34. Risedronate Sodium (usp)

35. Chembl1654

36. Schembl18377

37. Risedronate Sodium, Min 97%

38. Chebi:8868

39. Dtxsid20924178

40. Risedronate Sodium [vandf]

41. Risedronate Sodium [mart.]

42. Act03362

43. Bcp22742

44. Hy-b0119

45. Risedronate Sodium [usp-rs]

46. Risedronate Sodium [who-dd]

47. Ac-732

48. Mfcd01706268

49. S1428

50. Akos015833432

51. Ab09807

52. Ccg-213235

53. Cs-1883

54. Nsc 722598

55. Nsc 759280

56. Risedronate Sodium [orange Book]

57. Ncgc00346521-01

58. Ac-20120

59. As-13309

60. Risedronate Sodium [usp Monograph]

61. Ft-0631078

62. M2289

63. Risedronic Acid Monosodium Salt [mi]

64. D00942

65. H11438

66. Ab01274790-01

67. Q-201723

68. Q27285633

69. 2-(3-pyridinyl)-2-hydroxyethylidene-1,1-bisphosphonate

70. Monosodium 1-hydroxy-2-(3-pyridyl)ethylidene-1,1-diphosphonate

71. 1-hydroxy-2-(3-pyridinyl) Ethylidene Bis-phosphonic Acid Monosodium Salt

72. Hydrogen [1-hydroxy-1-phosphono-2-(pyridin-3-yl)ethyl]phosphonate (na+)

73. P,p'-[1-hydroxy-2-(3-pyridonyl)ethylidene]bis-phosphonic Acid Sodium Salt

74. Phosphonic Acid, (1-hydroxy-2-(3-pyridinyl)ethylidene)bis-, Disodium Salt

75. Phosphonic Acid, (2-hydroxy-2-(3-pyridinyl)ethylidene)bis-, Disodium Salt

76. Risedronate Sodium, United States Pharmacopeia (usp) Reference Standard

77. Risedronate Sodium;risedronic Acid Sodium;ne-58095; Ne 58095; Ne58095

78. Sodium Hydrogen-1-hydroxy-1-phosphono-2-(pyridin-3-yl)ethylphosphonate

79. Sodium;hydroxy-(1-hydroxy-1-phosphono-2-pyridin-3-ylethyl)phosphinate

80. (1-hydroxy-2-(pyridin-3-yl)ethane-1,1-diyl)bis(phosphonic Acid) Sodium Salt

81. Risedronate Sodium 2.5-hydrate, European Pharmacopoeia (ep) Reference Standard

82. Risedronate Sodium, Pharmaceutical Secondary Standard; Certified Reference Material

83. 934544-85-1

2.4 Create Date
2005-09-13
3 Chemical and Physical Properties
Molecular Weight 305.09 g/mol
Molecular Formula C7H10NNaO7P2
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count8
Rotatable Bond Count4
Exact Mass304.98301994 g/mol
Monoisotopic Mass304.98301994 g/mol
Topological Polar Surface Area151 Ų
Heavy Atom Count18
Formal Charge0
Complexity375
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Drug Information
1 of 6  
Drug NameActonel
PubMed HealthAntacid, Calcium Containing (By mouth)
Drug ClassesAntacid, Aluminum Containing, Antacid, Aluminum/Calcium/Magnesium Containing, Antacid, Calcium Containing, Antacid, Magnesium Containing, Antiflatulent, Calcium Supplement
Drug LabelACTONEL (risedronate sodium) tablets is a pyridinyl bisphosphonate that inhibits osteoclast-mediated bone resorption and modulates bone metabolism. Each ACTONEL tablet for oral administration contains the equivalent of 5, 30, 35, 75, or 150 mg of anh...
Active IngredientRisedronate sodium
Dosage FormTablet
RouteOral
Strength5mg; 30mg; 150mg; 35mg
Market StatusPrescription
CompanyWarner Chilcott

2 of 6  
Drug NameAtelvia
Drug LabelAtelvia (risedronate sodium) delayed-release tablets contain a pH-sensitive enteric coating and a chelating agent (EDTA). Risedronate is a pyridinyl bisphosphonate that inhibits osteoclast-mediated bone resorption and modulates bone metabolism. Each...
Active IngredientRisedronate sodium
Dosage FormTablet, delayed release
RouteOral
Strength35mg
Market StatusPrescription
CompanyWarner Chilcott

3 of 6  
Drug NameRisedronate sodium
PubMed HealthRisedronate (By mouth)
Drug ClassesCalcium Regulator
Drug LabelACTONEL (risedronate sodium) tablets is a pyridinyl bisphosphonate that inhibits osteoclast-mediated bone resorption and modulates bone metabolism. Each ACTONEL tablet for oral administration contains the equivalent of 5, 30, 35, 75, or 150 mg of anh...
Active IngredientRisedronate sodium
Dosage FormTablet
Routeoral; Oral
Strength30mg; 150mg; 75mg; 5mg; 35mg
Market StatusTentative Approval; Prescription
CompanyMylan Pharms; Apotex; Aurobindo Pharma; Teva Pharms Usa; Sun Pharma Global; Teva Pharms

4 of 6  
Drug NameActonel
PubMed HealthAntacid, Calcium Containing (By mouth)
Drug ClassesAntacid, Aluminum Containing, Antacid, Aluminum/Calcium/Magnesium Containing, Antacid, Calcium Containing, Antacid, Magnesium Containing, Antiflatulent, Calcium Supplement
Drug LabelACTONEL (risedronate sodium) tablets is a pyridinyl bisphosphonate that inhibits osteoclast-mediated bone resorption and modulates bone metabolism. Each ACTONEL tablet for oral administration contains the equivalent of 5, 30, 35, 75, or 150 mg of anh...
Active IngredientRisedronate sodium
Dosage FormTablet
RouteOral
Strength5mg; 30mg; 150mg; 35mg
Market StatusPrescription
CompanyWarner Chilcott

5 of 6  
Drug NameAtelvia
Drug LabelAtelvia (risedronate sodium) delayed-release tablets contain a pH-sensitive enteric coating and a chelating agent (EDTA). Risedronate is a pyridinyl bisphosphonate that inhibits osteoclast-mediated bone resorption and modulates bone metabolism. Each...
Active IngredientRisedronate sodium
Dosage FormTablet, delayed release
RouteOral
Strength35mg
Market StatusPrescription
CompanyWarner Chilcott

6 of 6  
Drug NameRisedronate sodium
PubMed HealthRisedronate (By mouth)
Drug ClassesCalcium Regulator
Drug LabelACTONEL (risedronate sodium) tablets is a pyridinyl bisphosphonate that inhibits osteoclast-mediated bone resorption and modulates bone metabolism. Each ACTONEL tablet for oral administration contains the equivalent of 5, 30, 35, 75, or 150 mg of anh...
Active IngredientRisedronate sodium
Dosage FormTablet
Routeoral; Oral
Strength30mg; 150mg; 75mg; 5mg; 35mg
Market StatusTentative Approval; Prescription
CompanyMylan Pharms; Apotex; Aurobindo Pharma; Teva Pharms Usa; Sun Pharma Global; Teva Pharms

5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Bone Density Conservation Agents

Agents that inhibit BONE RESORPTION and/or favor BONE MINERALIZATION and BONE REGENERATION. They are used to heal BONE FRACTURES and to treat METABOLIC BONE DISEASES such as OSTEOPOROSIS. (See all compounds classified as Bone Density Conservation Agents.)


Calcium Channel Blockers

A class of drugs that act by selective inhibition of calcium influx through cellular membranes. (See all compounds classified as Calcium Channel Blockers.)


5.2 FDA Pharmacological Classification
5.2.1 Pharmacological Classes
Bisphosphonate [EPC]; Diphosphonates [CS]; Bisphosphonate [EPC]

API Reference Price

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