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    List of Drug Master Files (JDMF) of Active Pharmaceutical Ingredients (APIs) submitted by Merck Group to the Review Authority in Japan (PMDA). Original Data : PMDA

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    Bisoprolol fumarate

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    MERCK&CIE
    2014-01-07
    2008-05-15
    220MF10126
    WEISSHAUSMATTE CH-6460 AL...
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    Bisoprolol fumarate

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    MERCK&CIE KG
    2006-04-27
    2005-11-21
    217MF11012
    WEISSHAUSMATTE CH-6460 AL...
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    Calcium folinate

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    Merck & Cie
    2011-08-19
    2006-03-17
    218MF10352
    Weisshausmatte CH-6460 Al...
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      Cetuximab concentrated bulk

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      Merck Serono S. A.
      2023-12-06
      2023-12-06
      305MF10129
      Zone industriale de l\'Au...
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        Cetuximab concentrated bulk

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        Merck Serono S. A.
        2020-08-05
        2019-09-11
        301MF10063
        Zone industriale de l'Aur...
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        Co-carboxylase

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        Merck KGaA
        2009-12-07
        2009-12-07
        221MF10266
        Frankfurter Strasse 250 6...
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        Dactinomycin USP

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        SIGMA-ALDRICH ISRAEL Ltd.
        2017-02-13
        2009-08-13
        221MF10187
        13 Kiryat Mada Street, Ha...
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          Ella peg Ade Ma Ze

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          Exelead, Inc.
          2023-11-08
          2018-02-05
          230MF10020
          6925 Guion Road, Indianap...
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          Levofolinate calcium

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          Merck & Cie
          2018-12-03
          2005-12-20
          217MF11281
          Weisshausmatte CH-6460 Al...
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          Medium / medium additive · EX-CELL (TM) 302 (Modified ...

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          SAFC Biosciences, Inc.
          2018-01-15
          2018-01-15
          230MF40003
          13804 West 107th Street L...
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          Medium / Medium Additive ・ EX-CELL (TM) 6GRO w / L-Gl...

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          Sigma-Aldrich Company Lim...
          2022-03-10
          2022-03-10
          304MF40011
          Second Avenue Heatherhous...
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          Medium / Medium Additive ・ EX-CELL (TM) 6GRO w / L-Gl...

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          SAFC Biosciences, Inc.
          2022-03-10
          2022-03-10
          304MF40012
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          Medium / Medium Additives-EX-CELL Advanced CHO Feed 1 (...

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          SAFC Biosciences, Inc.
          2020-01-24
          2020-01-24
          302MF40001
          13804 West 107th Street L...
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          Medium / Medium Additives-EX-CELL Advanced CHO Feed 1 (...

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          Sigma-Aldrich Company Lim...
          2020-01-24
          2020-01-24
          302MF40004
          Second Avenue Heatherhous...
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          Medium/medium additive R7B-2 w/o L-Tyrosine

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          Sigma-Aldrich Company Lim...
          2022-05-18
          2022-05-18
          304MF40021
          Second Avenue Heatherhous...
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          Medium/medium additive R7B-2 w/o L-Tyrosine

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          SAFC Biosciences, Inc.
          2022-05-18
          2022-05-18
          304MF40022
          13804 West 107th Street L...
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          Nicotinic acid benzyl ester

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          Merck KGaA
          2010-01-22
          2010-01-22
          222MF10027
          Frankfurter Strasse 250 6...
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          Saffinamide mesylate

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          Merck KGaA
          2018-08-02
          2018-08-02
          230MF10101
          Frankfurter Strasse 250 6...
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          Media/Media Additives GS2-N Low B12 No Hydrocort

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          SAFC Biosciences, Inc.
          2022-12-23
          2022-12-23
          304MF40050
          13804 West 107th Street L...
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          Media/Media Additives GS2-N Low B12 No Hydrocort

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          Sigma-Aldrich Company Lim...
          2022-12-23
          2022-12-23
          304MF40049
          Second Avenue Heatherhous...
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          Media/Media Additives ・Trace Element E 1000X Solution

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          Sigma-Aldrich Manufacturi...
          2022-05-25
          2022-05-25
          304MF40026
          3506 South Broadway, Sain...
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          Medium / media supplements · EX-CELL (TM) 325 PF CHO P...

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          SAFC Biosciences, Inc.
          2017-11-07
          2017-11-07
          229MF40024
          13804 West 107th Street L...
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          Medium / Medium Additive / IMB8

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          SAFC Biosciences, Inc.
          2019-10-08
          2019-10-08
          301MF40019
          13804 West 107th Street L...
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          Medium / Medium Additive / IMB9

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          SAFC Biosciences, Inc.
          2019-10-08
          2019-10-08
          301MF40022
          13804 West 107th Street L...
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          Medium / Medium Additive / IMF8

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          SAFC Biosciences, Inc.
          2019-10-08
          2019-10-08
          301MF40020
          13804 West 107th Street L...
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          Medium / Medium Additive / PER2

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          SAFC Biosciences, Inc.
          2019-10-08
          2019-10-08
          301MF40024
          13804 West 107th Street L...
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          Medium / medium additive · C8862: EX-CELL CHO DHFR - M...

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          SAFC Sigma-Aldrich Corpor...
          2016-10-17
          2016-10-17
          228MF40026
          3050 Spruce Street Saint ...
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          • FDA
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          Medium / medium additive · CHO Feed Bioreactor Supplem...

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          Sigma-Aldrich manufacturi...
          2017-06-21
          2017-06-21
          229MF40009
          3506 South Broadway Saint...
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          • FDA
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          Medium / medium additive · EX-CELL 325 PF CHO Serum-Fr...

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          Sigma-Aldrich Company Lim...
          2017-11-07
          2017-11-07
          229MF40025
          Second Avenue Heatherhous...
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          • FDA
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          Medium / medium additive · EX-CELL EBx GRO-Ⅰ Serum-F...

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          Sigma-Aldrich manufacturi...
          2017-09-21
          2017-09-21
          229MF40018
          3506 South Broadway Saint...
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          Medium / medium additive · Ex-CELL EBx GRO-Ⅰ Serum-F...

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          SAFC Biosciences, Inc.
          2017-06-21
          2017-06-21
          229MF40011
          13804 West 107th Street L...
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          • FDA
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          Medium / medium additive · EX-CELL EBx PRO-Ⅰ Serum-F...

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          Sigma-Aldrich manufacturi...
          2017-09-21
          2017-09-21
          229MF40019
          3506 South Broadway Saint...
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          Medium / medium additive · EX-CELL EBx PRO-Ⅰ Serum-F...

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          SAFC Biosciences, Inc.
          2017-06-21
          2017-06-21
          229MF40012
          13804 West 107th Street L...
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          • FDA
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          Medium / medium additive · Fatty Acid Supplement

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          Sigma-Aldrich Manufacturi...
          2017-06-21
          2017-06-21
          229MF40010
          3506 South Broadway, Sain...
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          Medium / medium additive · Sigma EX-CELL 302 Serum-Fr ...

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          SAFC Biosciences, Inc.
          2015-10-21
          2015-10-21
          227MF40014
          13804 West 107th Street L...
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          Medium / medium additive · Sigma EX-CELL PF CHO Mediu ...

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          SAFC Biosciences, Inc.
          2015-12-11
          2015-12-11
          227MF40017
          13804 West 107th Street L...
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          • FDA
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          Medium / medium additive · StemlineⅡ Hematopoietic S...

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          Sigma-Aldrich Manufacturi...
          2017-11-21
          2017-11-21
          229MF40026
          3506 South Broadway, Sain...
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          • FDA
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          Medium / medium additive · X011Sb Cell Culture Medium

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          Merck KGaA
          2016-10-11
          2016-10-11
          228MF40024
          Frankfurter Strasse 250, ...
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          Medium / Medium Additive ・ CHOKO Production Medium Po...

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          SAFC Biosciences, Inc.
          2020-09-24
          2020-09-24
          302MF40029
          13804 West 107th Street L...
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          Medium / Medium Additive ・ CHOKO Production Medium Po...

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          Sigma-Aldrich Company Lim...
          2020-10-01
          2020-10-01
          302MF40038
          Second Avenue Heatherhous...
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          Medium / Medium Additive ・ IMF9-2X

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          SAFC Biosciences, Inc.
          2019-10-08
          2019-10-08
          301MF40023
          13804 West 107th Street L...
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          Medium / Medium Additive ・ TE1

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          Sigma-Aldrich Manufacturi...
          2019-10-08
          2019-10-08
          301MF40025
          3506 South Broadway, Sain...
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          Medium / Medium Additives FX-208 Cell Culture Medium

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          Merck KGaA
          2020-09-24
          2020-09-24
          302MF40031
          Frankfurter Strasse 250 6...
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          Medium / Medium Additives MX-209 Cell Culture Medium

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          Merck KGaA
          2020-09-24
          2020-09-24
          302MF40030
          Frankfurter Strasse 250 6...
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          Medium / Medium Additives ・ CHO Kit 2 Iron Chelator S...

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          Sigma-Aldrich Company Lim...
          2020-02-27
          2020-02-27
          302MF40007
          Second Avenue Heatherhous...
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          Medium / Medium Additives ・ CHOKO FMA Powerer

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          SAFC Biosciences, Inc.
          2020-09-24
          2020-09-24
          302MF40027
          13804 West 107th Street L...
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          Medium / Medium Additives ・ CHOKO FMA Powerer

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          Sigma-Aldrich Company Lim...
          2020-10-01
          2020-10-01
          302MF40036
          Second Avenue Heatherhous...
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          Medium / Medium Additives ・ CHOKO FMB Powerer

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          SAFC Biosciences, Inc.
          2020-09-24
          2020-09-24
          302MF40028
          13804 West 107th Street L...
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          Medium / Medium Additives ・ CHOKO FMB Powerer

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          Sigma-Aldrich Company Lim...
          2020-10-01
          2020-10-01
          302MF40037
          Second Avenue Heatherhous...
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          Medium / Medium Additives ・ CHOKO Stock Culture Mediu...

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          Sigma-Aldrich Company Lim...
          2020-10-01
          2020-10-01
          302MF40039
          Second Avenue Heatherhous...
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