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The net proceeds will be focusing on the development of SC291, which is a hypoimmune allogeneic CD19-directed CAR T cell therapy, for relapsed and/or refractory B-cell malignancies, including Non-Hodgkin lymphoma and Chronic lymphocytic leukemia.


Lead Product(s): SC291

Therapeutic Area: Oncology Product Name: SC291

Highest Development Status: Phase IProduct Type: Cell and Gene therapy

Partner/Sponsor/Collaborator: Morgan Stanley

Deal Size: $189.7 million Upfront Cash: Undisclosed

Deal Type: Public Offering February 12, 2024

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The net proceeds will be focusing on the development of SC291, which is a hypoimmune allogeneic CD19-directed CAR T cell therapy, for relapsed and/or refractory B-cell malignancies, including Non-Hodgkin lymphoma and Chronic lymphocytic leukemia.


Lead Product(s): SC291

Therapeutic Area: Oncology Product Name: SC291

Highest Development Status: Phase IProduct Type: Cell and Gene therapy

Partner/Sponsor/Collaborator: Morgan Stanley

Deal Size: $165.0 million Upfront Cash: Undisclosed

Deal Type: Public Offering February 08, 2024

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The net proceeds will be focusing on the development of SC291, which is a hypoimmune allogeneic CD19-directed CAR T cell therapy, for relapsed and/or refractory B-cell malignancies, including Non-Hodgkin lymphoma and Chronic lymphocytic leukemia.


Lead Product(s): SC291

Therapeutic Area: Oncology Product Name: SC291

Highest Development Status: Phase IProduct Type: Cell and Gene therapy

Partner/Sponsor/Collaborator: Morgan Stanley

Deal Size: $125.0 million Upfront Cash: Undisclosed

Deal Type: Public Offering February 07, 2024

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SC262 is a hypoimmune, CD22-directed allogeneic CAR T cell therapy derived from healthy donor CD4+ and CD8+ T cells. It is under preclinical development for the treatment of patients with relapsed or refractory B-cell malignancies.


Lead Product(s): SC262

Therapeutic Area: Oncology Product Name: SC262

Highest Development Status: IND EnablingProduct Type: Cell and Gene therapy

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable December 05, 2023

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UP421 is an allogeneic, primary islet cell therapy engineered with Sana’s hypoimmune (HIP) technology, which is being evaluated for the treatment of patients with type 1 diabetes.


Lead Product(s): UP421

Therapeutic Area: Endocrinology Product Name: UP421

Highest Development Status: PreclinicalProduct Type: Cell and Gene therapy

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable November 17, 2023

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SC291, a Hypoimmune-modified, CD19-directed Allogeneic CAR T Therapy, for Patients with Lupus Nephritis, Extrarenal Lupus, and ANCA-associated Vasculitis.


Lead Product(s): SC291

Therapeutic Area: Nephrology Product Name: SC291

Highest Development Status: IND EnablingProduct Type: Cell and Gene therapy

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable November 09, 2023

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SC291 is a CD19-targeted allogeneic CAR T cell therapy developed using Sana’s hypoimmune platform. SC291 may result in longer CAR T cell persistence and a higher rate of durable complete responses for patients with B-cell lymphomas or leukemias.


Lead Product(s): SC291

Therapeutic Area: Oncology Product Name: SC291

Highest Development Status: IND EnablingProduct Type: Cell and Gene therapy

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable January 26, 2023

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The company expects to study SG295, an in vivo CAR T with CD8-targeted fusosome delivery of a CD19-targeted CAR, in B cell malignancies. With increased potency, SG295 has the potential to generate a comparable no. of CAR T cells to current ex vivo manufacturing processes.


Lead Product(s): SG295

Therapeutic Area: Oncology Product Name: SG295

Highest Development Status: PreclinicalProduct Type: Cell and Gene therapy

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable December 11, 2022

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The SC291 preclinical data demonstrate these hypoimmunogenic CAR T cells are able to evade both the innate and adaptive arms of the immune system while retaining their antitumor activity.


Lead Product(s): SC291

Therapeutic Area: Oncology Product Name: SC291

Highest Development Status: PreclinicalProduct Type: Cell and Gene therapy

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable November 03, 2022

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First demonstration of SC291, survival of allogeneic islet cells, cardiomyocytes, and retinal pigment epithelium cells transplanted into an immunocompetent non-human primate model without any immune suppression.


Lead Product(s): SC291

Therapeutic Area: Oncology Product Name: SC291

Highest Development Status: PreclinicalProduct Type: Cell and Gene therapy

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable June 17, 2022

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