Company profile for QurAlis

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About

QurAlis is developing precision therapeutics for ALS, a terminal disease that causes muscle paralysis through degeneration of the motor system. We are digging deep into the root causes of the multiple sub-forms of this destructive disease and focus our programs on tackling specific disease-causing mechanisms. The QurAlis strategy is to attack ALS one gene at a time by using a transformative system in which cells from ALS pa...
QurAlis is developing precision therapeutics for ALS, a terminal disease that causes muscle paralysis through degeneration of the motor system. We are digging deep into the root causes of the multiple sub-forms of this destructive disease and focus our programs on tackling specific disease-causing mechanisms. The QurAlis strategy is to attack ALS one gene at a time by using a transformative system in which cells from ALS patients are used to model the disease in the lab to identify new drugs. QurAlis cofounders Kevin Eggan and Clifford Woolf, both Harvard professors, have pioneered this discovery technology for ALS.

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CONTACT DETAILS

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Country
Country
U.S.A
Address
Address
700 Main Street, North Cambridge, MA 02139
Telephone
Telephone
(+1) 617.682.6015
Linkedin
Linkedin
youtube
YouTube
Twitter
Twitter

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Events

Webinars & Exhibitions

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Meeting

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NEWS #PharmaBuzz

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https://www.businesswire.com/news/home/20251229117640/en/QurAlis-Confirms-Signal-of-Target-Engagement-in-ALS-Patients-in-Phase-1-Clinical-Trial-of-QRL-101-a-Potentially-Best-in-Class-Selective-Kv7.27.3-Ion-Channel-Opener

BUSINESSWIRE
29 Dec 2025

https://www.pharmiweb.com/press-release/2025-12-18/quralis-invited-to-present-at-44th-annual-jp-morgan-healthcare-conference

PHARMIWEB
18 Dec 2025

https://www.businesswire.com/news/home/20251202434479/en/QurAlis-to-Present-Data-From-its-Phase-1-Clinical-Trial-of-QRL-101-a-Potential-Best-in-Class-Selective-Kv7.27.3-Ion-Channel-Opener-at-American-Epilepsy-Society-2025-Annual-Meeting

BUSINESSWIRE
02 Dec 2025

https://www.businesswire.com/news/home/20251120380958/en/QurAlis-to-Participate-in-Piper-Sandler-37th-Annual-Healthcare-Conference

BUSINESSWIRE
20 Nov 2025

https://www.businesswire.com/news/home/20251110510651/en/QurAlis-Announces-Appointment-of-Manoj-Malhotra-M.D.-as-Chief-Medical-Officer

BUSINESS WIRE
10 Nov 2025

https://www.businesswire.com/news/home/20251103871526/en/QurAlis-to-Participate-in-Upcoming-Investor-Conferences-in-November

BUSINESSWIRE
03 Nov 2025

Drugs in Development

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Details:

Under the licensing agreement, QurAlis explore the biology of FXS to determine and confirm relevant targets that could enable antisense oligonucleotide (ASO)-mediated correction for FXS.


Lead Product(s): Undisclosed

Therapeutic Area: Genetic Disease Brand Name: Undisclosed

Study Phase: DiscoveryProduct Type: Undisclosed

Recipient: UMass Chan Medical School

Deal Size: Undisclosed Upfront Cash: Undisclosed

Deal Type: Licensing Agreement May 15, 2025

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QurAlis

U.S.A
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BIO Partnering at JPM
Not Confirmed

QurAlis

U.S.A
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BIO Partnering at JPM
Not Confirmed

Details : Under the licensing agreement, QurAlis explore the biology of FXS to determine and confirm relevant targets that could enable antisense oligonucleotide (ASO)-mediated correction for FXS.

Product Name : Undisclosed

Product Type : Undisclosed

Upfront Cash : Undisclosed

May 15, 2025

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Details:

QRL-101 is a Other Small Molecule drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of undefined medical condition.


Lead Product(s): QRL-101

Therapeutic Area: Undisclosed Brand Name: Undisclosed

Study Phase: Phase IProduct Type: Miscellaneous

Sponsor: Undisclosed

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable March 14, 2025

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QurAlis

U.S.A
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BIO Partnering at JPM
Not Confirmed

QurAlis

U.S.A
arrow
BIO Partnering at JPM
Not Confirmed

Details : QRL-101 is a Other Small Molecule drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of undefined medical condition.

Product Name : Undisclosed

Product Type : Miscellaneous

Upfront Cash : Inapplicable

March 14, 2025

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Details:

QRL-101 is a potentially best-in-class selective Kv7.2/7.3 ion channel opener for the treatment of hyperexcitability-induced disease progression in ALS


Lead Product(s): QRL-101

Therapeutic Area: Neurology Brand Name: Undisclosed

Study Phase: Phase IProduct Type: Miscellaneous

Sponsor: Undisclosed

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable March 12, 2025

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QurAlis

U.S.A
arrow
BIO Partnering at JPM
Not Confirmed

QurAlis

U.S.A
arrow
BIO Partnering at JPM
Not Confirmed

Details : QRL-101 is a potentially best-in-class selective Kv7.2/7.3 ion channel opener for the treatment of hyperexcitability-induced disease progression in ALS

Product Name : Undisclosed

Product Type : Miscellaneous

Upfront Cash : Inapplicable

March 12, 2025

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Details:

QRL-101 is a Other Small Molecule drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of Amyotrophic Lateral Sclerosis.


Lead Product(s): QRL-101

Therapeutic Area: Neurology Brand Name: Undisclosed

Study Phase: Phase IProduct Type: Miscellaneous

Sponsor: Undisclosed

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable December 03, 2024

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QurAlis

U.S.A
arrow
BIO Partnering at JPM
Not Confirmed

QurAlis

U.S.A
arrow
BIO Partnering at JPM
Not Confirmed

Details : QRL-101 is a Other Small Molecule drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of Amyotrophic Lateral Sclerosis.

Product Name : Undisclosed

Product Type : Miscellaneous

Upfront Cash : Inapplicable

December 03, 2024

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Details:

QRL-201 is a first-in-class therapeutic product candidate aiming to restore STMN2 expression in Amyotrophic lateral sclerosis patients.


Lead Product(s): QRL-201

Therapeutic Area: Neurology Brand Name: Undisclosed

Study Phase: Phase IProduct Type: Oligonucleotide

Sponsor: Undisclosed

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable November 19, 2024

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05

QurAlis

U.S.A
arrow
BIO Partnering at JPM
Not Confirmed

QurAlis

U.S.A
arrow
BIO Partnering at JPM
Not Confirmed

Details : QRL-201 is a first-in-class therapeutic product candidate aiming to restore STMN2 expression in Amyotrophic lateral sclerosis patients.

Product Name : Undisclosed

Product Type : Oligonucleotide

Upfront Cash : Inapplicable

November 19, 2024

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Details:

QRL-101 is a Other Small Molecule drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of undefined medical condition.


Lead Product(s): QRL-101

Therapeutic Area: Undisclosed Brand Name: Undisclosed

Study Phase: Phase IProduct Type: Miscellaneous

Sponsor: Centre for Human Drug Research

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable November 08, 2024

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QurAlis

U.S.A
arrow
BIO Partnering at JPM
Not Confirmed

QurAlis

U.S.A
arrow
BIO Partnering at JPM
Not Confirmed

Details : QRL-101 is a Other Small Molecule drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of undefined medical condition.

Product Name : Undisclosed

Product Type : Miscellaneous

Upfront Cash : Inapplicable

November 08, 2024

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Details:

QRL-101 is a Other Small Molecule drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of undefined medical condition.


Lead Product(s): QRL-101

Therapeutic Area: Undisclosed Brand Name: Undisclosed

Study Phase: Phase IProduct Type: Miscellaneous

Sponsor: Undisclosed

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable August 01, 2024

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07

QurAlis

U.S.A
arrow
BIO Partnering at JPM
Not Confirmed

QurAlis

U.S.A
arrow
BIO Partnering at JPM
Not Confirmed

Details : QRL-101 is a Other Small Molecule drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of undefined medical condition.

Product Name : Undisclosed

Product Type : Miscellaneous

Upfront Cash : Inapplicable

August 01, 2024

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Details:

QurAlis granted Lilly an exclusive, worldwide license to develop and commercialize QRL-204, a potentially best-in-class splice-switching ASO and other UNC13A-targeting compounds.


Lead Product(s): QRL-204

Therapeutic Area: Neurology Brand Name: Undisclosed

Study Phase: PreclinicalProduct Type: Miscellaneous

Sponsor: Eli Lilly

Deal Size: $622.0 million Upfront Cash: $45.0 million

Deal Type: Licensing Agreement June 03, 2024

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QurAlis

U.S.A
arrow
BIO Partnering at JPM
Not Confirmed

QurAlis

U.S.A
arrow
BIO Partnering at JPM
Not Confirmed

Details : QurAlis granted Lilly an exclusive, worldwide license to develop and commercialize QRL-204, a potentially best-in-class splice-switching ASO and other UNC13A-targeting compounds.

Product Name : Undisclosed

Product Type : Miscellaneous

Upfront Cash : $45.0 million

June 03, 2024

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Details:

QRL-201 is a first-in-class precision therapeutic product candidate aiming to restore STATHMIN-2 (STMN2) expression in ALS patients. ANQUR is the first-ever study to evaluate a therapy that rescues STMN2 expression in ALS patients.


Lead Product(s): QRL-201

Therapeutic Area: Neurology Brand Name: Undisclosed

Study Phase: Phase IProduct Type: Oligonucleotide

Sponsor: Undisclosed

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable June 06, 2023

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QurAlis

U.S.A
arrow
BIO Partnering at JPM
Not Confirmed

QurAlis

U.S.A
arrow
BIO Partnering at JPM
Not Confirmed

Details : QRL-201 is a first-in-class precision therapeutic product candidate aiming to restore STATHMIN-2 (STMN2) expression in ALS patients. ANQUR is the first-ever study to evaluate a therapy that rescues STMN2 expression in ALS patients.

Product Name : Undisclosed

Product Type : Oligonucleotide

Upfront Cash : Inapplicable

June 06, 2023

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Details:

The proceeds from the financing will fund clinical development of QRL-201 and QRL-101, QurAlis's lead product candidates in ALS. QRL-201 is a first-in-class therapeutic product candidate aiming to restore STMN2 expression in ALS patients.


Lead Product(s): QRL-201

Therapeutic Area: Neurology Brand Name: Undisclosed

Study Phase: Phase IProduct Type: Oligonucleotide

Sponsor: EQT Life Sciences

Deal Size: $88.0 million Upfront Cash: Undisclosed

Deal Type: Series B Financing March 09, 2023

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10

QurAlis

U.S.A
arrow
BIO Partnering at JPM
Not Confirmed

QurAlis

U.S.A
arrow
BIO Partnering at JPM
Not Confirmed

Lead Product(s) : QRL-201

Therapeutic Area : Neurology

Highest Development Status : Phase I

Partner/Sponsor/Collaborator : EQT Life Sciences

Deal Size : $88.0 million

Deal Type : Series B Financing

Details : The proceeds from the financing will fund clinical development of QRL-201 and QRL-101, QurAlis's lead product candidates in ALS. QRL-201 is a first-in-class therapeutic product candidate aiming to restore STMN2 expression in ALS patients.

Product Name : Undisclosed

Product Type : Oligonucleotide

Upfront Cash : Undisclosed

March 09, 2023

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