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OR502 a novel, humanized anti-leukocyte immunoglobulin like receptor B2 (LILRB2) antibody. It is being evaluated for the treatment of advanced solid tumors.


Lead Product(s): OR502,Cemiplimab

Therapeutic Area: Oncology Product Name: OR502

Highest Development Status: Phase I/ Phase IIProduct Type: Large molecule

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable November 29, 2023

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The CPRIT award will support the advancement of OR502, a best-in-class anti-LILRB2 antibody that rescues innate and adaptive immune responses from LILRB2-mediated immune suppression, poised to move to IND and clinical studies.


Lead Product(s): OR502

Therapeutic Area: Oncology Product Name: OR502

Highest Development Status: IND EnablingProduct Type: Large molecule

Partner/Sponsor/Collaborator: CPRIT

Deal Size: $13.0 million Upfront Cash: Undisclosed

Deal Type: Funding May 18, 2023

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The investment will support the advancement of OR502, a best-in-class anti-LILRB2 antibody that rescues innate and adaptive immune responses from LILRB2-mediated immune suppression, poised to move to IND and clinical studies.


Lead Product(s): OR502

Therapeutic Area: Oncology Product Name: OR502

Highest Development Status: IND EnablingProduct Type: Large molecule

Partner/Sponsor/Collaborator: RiverVest Venture Partners

Deal Size: $14.0 million Upfront Cash: Undisclosed

Deal Type: Financing May 18, 2023

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The supply agreement will support the evaluation of Libtayo in combination with OR2805, a fully human monoclonal antibody identified from an elite cancer responder using OncoResponse’s proprietary B-cell discovery platform.


Lead Product(s): OR2805,Cemiplimab

Therapeutic Area: Oncology Product Name: OR2805

Highest Development Status: PreclinicalProduct Type: Large molecule

Partner/Sponsor/Collaborator: Regeneron Pharmaceuticals

Deal Size: Undisclosed Upfront Cash: Undisclosed

Deal Type: Agreement September 07, 2022

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