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Approximately 50% of all cancer patients will receive radiation therapy (RT) during the course of their illness. In most solid tumors, hypoxia occurs to some degree as a result of several factors, including the rapid growth rate of cancer cells and the highly disorganized/inefficient vasculature. X-rays and electron beams are the main forms of radiation to treat cancer. Most of the damage is not caused by the radiation energy directly damaging tumor cells (Direct effect), but rather by the radiation energy creating highly reactive substances, especially so-called free radicals, that damage important structures in cells leading