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IGM Biosciences
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U.S.A
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325 East Middlefield Road Mountain View, CA 94043
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(650) 965-7873
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The company intends to use the net proceeds for its pipeline development including, IGM-8444, an IgM antibody targeting Death Receptor 5 (DR5) that is being developed for the treatment of patients with solid and hematologic malignancies.


Lead Product(s): IGM-8444,Bevacizumab,Fluorouracil

Therapeutic Area: Oncology Product Name: IGM-8444

Highest Development Status: Phase IProduct Type: Large molecule

Partner/Sponsor/Collaborator: BofA Securities

Deal Size: $80.0 million Upfront Cash: Undisclosed

Deal Type: Public Offering June 22, 2023

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IGM-8444 is an IgM antibody targeting death receptor 5 (DR5) that is being developed for the treatment of patients with solid tumor including metastatic colorectal cancerand hematologic malignancies.


Lead Product(s): IGM-8444,Bevacizumab,Fluorouracil

Therapeutic Area: Oncology Product Name: IGM-8444

Highest Development Status: Phase IProduct Type: Large molecule

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable June 02, 2023

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IGM-2323 (imvotamab), a novel IgM-based CD20 x CD3 bispecific antibody T cell engager (TCE), cleared two IND applications, enabling the initiation of Phase 1b studies in both severe systemic lupus erythematosus (SLE) and severe rheumatoid arthritis (RA).


Lead Product(s): Imvotamab

Therapeutic Area: Immunology Product Name: IGM-2323

Highest Development Status: IND EnablingProduct Type: Large molecule

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable May 31, 2023

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IGM-7354 is a targeted IL-15/IL-15R IgM immune stimulating antibody for the treatment of patients with solid tumors and hematologic malignancies. IGM-7354 may enhance the immune system’s activity in the tumor microenvironment.


Lead Product(s): IGM-7354

Therapeutic Area: Oncology Product Name: IGM-7354

Highest Development Status: Phase IProduct Type: Large molecule

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable January 17, 2023

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IGM-8444 is an IgM antibody targeting Death Receptor 5 (DR5) that is being developed for the treatment of patients with solid and hematologic malignancies.


Lead Product(s): IGM-8444,Bevacizumab,Fluorouracil

Therapeutic Area: Oncology Product Name: IGM-8444

Highest Development Status: Phase IProduct Type: Large molecule

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable January 09, 2023

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Imvotamab (IGM-2323), the first-in-class CD20xCD3 bispecific IgM antibody with dual mechanisms of action, in patients with advanced B cell malignancies.


Lead Product(s): Imvotamab

Therapeutic Area: Oncology Product Name: IGM-2323

Highest Development Status: Phase I/ Phase IIProduct Type: Large molecule

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable December 11, 2022

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The collaboration is for the creation, development, manufacture, and commercialization of IgM antibody agonists against three oncology targets and three immunology/inflammation targets.


Lead Product(s): Engineered IgM Antibody

Therapeutic Area: Oncology Product Name: Undisclosed

Highest Development Status: Discovery PlatformProduct Type: Large molecule

Partner/Sponsor/Collaborator: Sanofi

Deal Size: $6,150.0 million Upfront Cash: $150.0 million

Deal Type: Collaboration May 06, 2022

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Under collaboration Sanofi and IGM will lead research, develop and commercialize IgM antibody agonists against three oncology targets and three immunology/inflammation targets by leveraging proprietary IgM antibody technology platform.


Lead Product(s): Engineered IgM Antibody

Therapeutic Area: Oncology Product Name: Undisclosed

Highest Development Status: Discovery PlatformProduct Type: Large molecule

Partner/Sponsor/Collaborator: Sanofi

Deal Size: $6,165.0 million Upfront Cash: $150.0 million

Deal Type: Collaboration March 29, 2022

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Based on the results, two Phase 2 studies are being initiated to assess the safety and efficacy of two doses of IGM-2323, in patients with DLBCL and FL. Data demonstrate that IGM-2323 is highly active against multiple subtypes of relapsed/ refractory non-Hodgkin’s lymphoma.


Lead Product(s): IGM-2323

Therapeutic Area: Oncology Product Name: IGM-2323

Highest Development Status: Phase IProduct Type: Large molecule

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable December 11, 2021

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Studies suggest that anti-CSP (circumsporozoite protein) monoclonal antibodies may be useful in protecting against infection and disease. Because of their multimeric format, IgM and IgA antibodies directed against CSP could potentially exhibit significantly improved potency.


Lead Product(s): Anti-CSP IgM Antibodies

Therapeutic Area: Infections and Infectious Diseases Product Name: Undisclosed

Highest Development Status: PreclinicalProduct Type: Large molecule

Partner/Sponsor/Collaborator: Bill & Melinda Gates Foundation

Deal Size: Undisclosed Upfront Cash: Undisclosed

Deal Type: Collaboration December 08, 2021

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