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Enterprise Therapeutics
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Country
Country
United Kingdom
Address
Address
Sussex Innovation Centre University of Sussex Science Park Square Falmer Brighton, BN1 9SB
Telephone
Telephone
+44 (0)1273 234667

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The financing will fund the Phase 2a clinical trial of the Company’s lead programme, ETD001, a novel first in class ENaC blocker, to deliver clinical proof of concept to treat cystic fibrosis.


Lead Product(s): ETD001

Therapeutic Area: Genetic Disease Product Name: ETD001

Highest Development Status: Phase IProduct Type: Small molecule

Partner/Sponsor/Collaborator: Panakes Partners

Deal Size: $33.1 million Upfront Cash: Undisclosed

Deal Type: Series B Financing January 30, 2024

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By increasing the amount of airway fluid available to hydrate mucus, ETD001 addresses the underlying mechanisms of mucus congestion, and is expected to restore lung function, reduce the frequency of lung infections and improve patient quality of life.


Lead Product(s): ETD001

Therapeutic Area: Genetic Disease Product Name: ETD001

Highest Development Status: Phase IProduct Type: Small molecule

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable June 14, 2021

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Enterprise Therapeutics' TMEM16A portfolio includes ETD002, first of its compounds to hit clinical stage. In pre-clinical models the compound has been found to enhances the activity of TMEM16A.


Lead Product(s): ETD002

Therapeutic Area: Pulmonary/Respiratory Diseases Product Name: ETD002

Highest Development Status: Phase IProduct Type: Small molecule

Partner/Sponsor/Collaborator: F. Hoffmann-La Roche

Deal Size: Undisclosed Upfront Cash: $96.8 milion

Deal Type: Acquisition October 07, 2020

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ETD002. The first-in-man safety study is being conducted in healthy participants with ETD002, a TMEM16A potentiator aimed at treating all people with cystic fibrosis (CF).


Lead Product(s): ETD002

Therapeutic Area: Genetic Disease Product Name: ETD002

Highest Development Status: Phase IProduct Type: Small molecule

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable August 17, 2020

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Paper demonstrates first in class TMEM16A chloride channel potentiators, to accelerate mucociliary clearance.


Lead Product(s): ETX001

Therapeutic Area: Genetic Disease Product Name: Undisclosed

Highest Development Status: PreclinicalProduct Type: Small molecule

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable January 08, 2020

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