Looking for 7784-46-5 / Sodium Metaarsenite API manufacturers, exporters & distributors?
Sodium Metaarsenite manufacturers, exporters & distributors
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API | Excipient name
Sodium Metaarsenite
Synonyms
7784-46-5, Sodium dioxoarsenate, Sodium;oxoarsinite, Sodium meta-arsenite, Sodium (meta)arsenite, Arsenite, sodium
Unique Ingredient Identifier (UNII)
48OVY2OC72
About Sodium Metaarsenite
Sodium Metaarsenite is a highly soluble, orally available trivalent arsenic-containing telomerase inhibitor with potential antitumor activity. Although the exact mechanism through which sodium metaarsenite exerts its effect has yet to be fully elucidated, this agent appears to target and bind to telomeric sequences, specifically TTAGGG repeats, leading to a shortening of telomeres, and subsequent induction of apoptosis and inhibition of tumor cell growth. In addition, sodium metaarsenite also leads to the translocation of the catalytic subunit of telomerase into the cytoplasm and inhibition of the activity of telomerase. Telomerase is active in most tumors cells and is responsible for the maintenance of telomere length and plays a key role in cellular proliferation, but is quiescent in normal, healthy cells. The susceptibility to sodium metaarsenite seems to be inversely correlated with initial length of telomeres.
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For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.