Looking for 670220-93-6 / Crenolanib Besylate API manufacturers, exporters & distributors?
Crenolanib Besylate manufacturers, exporters & distributors
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API | Excipient name
Crenolanib Besylate
Synonyms
670220-93-6, Crenolanib besilate, Crenolanib besylate [usan], Aro-002-26, Cp-868,596-26, Mc4b01024k
Unique Ingredient Identifier (UNII)
MC4B01024K
About Crenolanib Besylate
Crenolanib Besylate is the besylate salt form of crenolanib, an orally bioavailable benzimidazole targeting the platelet-derived growth factor receptor (PDGFR) subtypes alpha and beta and FMS-related tyrosine kinase 3 (Flt3), with potential antineoplastic activity. Upon oral administration, crenolanib binds to and inhibits both wild-type and mutated forms of PDGFR and Flt3, which may result in the inhibition of PDGFR- and Flt3-related signal transduction pathways. This results in inhibition of tumor angiogenesis and tumor cell proliferation in PDGFR and/or Flt3 overexpressing tumor cells. PDGFR and Flt3, class III receptor tyrosine kinases, are upregulated or mutated in many tumor cell types.
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For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.