Drug NameActive IngredientApplicantEstimated Sales (in Million USD)Chemical / BiologicalTherapeutic AreaFDA Approved IndicationApproval Date
DupixentDupilumabRegeneron / Sanofi $4,938 BiologicalDermatologyTo treat adults with moderate-to-severe eczema (atopic dermatitis)28/03/2017
OcrevusOcrelizumabGenentech$4,088 BiologicalImmunology / MusculoskeletalTo treat patients with relapsing and primary progressive forms of multiple sclerosis28/03/2017
BavencioAvelumabEMD Serono / Pfizer$3,000 BiologicalDermatology / OncologyTo treat metastatic Merkel cell carcinoma23/03/2017
CalquenceAcalabrutinibAstrazeneca / Acerta Pharma$2,500 ChemicalHematology / OncologyTo treat adults with mantle cell lymphoma31/10/2017
KisqaliRibociclib SuccinateNovartis Pharms Corp$2,500 ChemicalOncology / Obstetrics / Gynecology (Women’s Health)To treat postmenopausal women with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced or metastatic breast cancer13/03/2017
OzempicSemaglutideNovo Nordisk$2,243 ChemicalEndocrinology / Family MedicineTo improve glycemic control in adults with type 2 diabetes mellitus05/12/2017
HemlibraEmicizumabRoche $2,000 BiologicalHematologyTo prevent or reduce the frequency of bleeding episodes in adult and pediatric patients with hemophilia A who have developed antibodies called Factor VIII (FVIII) inhibitors.16/11/2017
ImfinziDurvalumabAstrazeneca / Medimmune$1,900 BiologicalUrology / OncologyTo treat patients with locally advanced or metastatic urothelial carcinoma01/05/2017
ZejulaNiraparibTesaro Inc$1,794 ChemicalOncology / Obstetrics / Gynecology (Women’s Health)For the maintenance treatment for recurrent epithelial ovarian, fallopian tube or primary peritoneal cancers27/03/2017
VerzenioAbemaciclibEli Lilly$1,792 ChemicalObstetrics / Gynecology (Women’s Health) / OncologyTo treat certain advanced or metastatic breast cancers28/09/2017
TremfyaGuselkumab Janssen Biotech$1,460 BiologicalDermatology / ImmunologyFor the treatment of adult patients with moderate-to-severe plaque psoriasis13/07/2017
NerlynxNeratinib MaleatePuma Biotech$1,300 ChemicalOncologyFor the extended adjuvant treatment of adult patients with early stage HER2-overexpressed/amplified breast cancer, to follow adjuvant trastuzumab-based therapy.17/07/2017
MavyretGlecaprevir & PibrentasvirAbbvie Inc$1,254 ChemicalHepatology (Liver, Pancreatic, Gall Bladder) / Infections and Infectious DiseasesTo treat adults with chronic hepatitis C virus 03/08/2017
VoseviSofosbuvir, Velpatasvir & VoxilaprevirGilead Sciences Inc$1,143 ChemicalHepatology (Liver, Pancreatic, Gall Bladder) / ImmunologyTo treat adults with chronic hepatitis C virus18/07/2017
SteglatroErtugliflozinPfizer / Merck$1,000 ChemicalEndocrinology / Family MedicineTo improve glycemic control in adults with type 2 diabetes mellitus19/12/2017
VyzultaLatanoprostene BunodValeant Pharmaceuticals International / Bausch & Lomb / Nicox$1,000 ChemicalOphthalmologyTo treat intraocular pressure in patients with open-angle glaucoma or ocular hypertension02/11/2017
BevyxxaBetrixabanPortola Pharms Inc$1,000 ChemicalCardiology / Vascular DiseasesFor the prophylaxis of venous thromboembolism (VTE) in adult patients hospitalized for an acute medical illness23/06/2017
KevzaraSarilumabRegeneron  / Sanofi $1,000 BiologicalMusculoskeletal / RheumatologyTo treat adult rheumatoid arthritis22/05/2017
IngrezzaValbenazine TosylateNeurocrine Biosciences Inc$1,000 ChemicalNeurologyTo treat adults with tardive dyskinesia 11/04/2017
AustedoDeutetrabenazine Teva Pharmaceutical Industries $850 ChemicalNeurologyFor the treatment of chorea associated with Huntington’s disease 03/04/2017 
AlunbrigBrigatinibAriad Pharmaceuticals Inc$800 ChemicalOncologyTo treat patients with anaplastic lymphoma kinase (ALK)-positive metastatic non-small cell lung cancer (NSCLC) who have progressed on or are intolerant to crizotinib28/04/2017
AliqopaCopanlisib DihydrochlorideBayer$700 ChemicalOncology / HematologyTo treat adults with relapsed follicular lymphoma14/09/2017
ParsabivEtelcalcetideAmgen$600 ChemicalNephrology / EndocrinologyTo treat secondary hyperparathyroidism in adult patients with chronic kidney disease undergoing dialysis07/02/2017
XermeloTelotristat EtiprateLexicon Pharmaceuticals Inc$539 ChemicalGastroenterology / OncologyTo treat carcinoid syndrome diarrhea28/02/2017
VabomereMeropenem & VaborbactamThe Medicines Company$520 ChemicalUrology / Infections and Infectious DiseasesTo treat adults with complicated urinary tract infections 29/08/2017
IdhifaEnasidenib MesylateCelgene Corp / Agios Pharmaceuticals Inc$500 ChemicalOncology / HematologyTo treat relapsed or refractory acute myeloid leukemia01/08/2017
BrineuraCerliponase AlfaBiomarin Pharm$500 BiologicalNeurology / Genetic Disease / Musculoskeletal / Pediatrics /  NeonatologyTo treat a specific form of Batten disease27/04/2017
GiaprezaAngiotensin IILa Jolla Pharmaceutical Company $500 ChemicalCardiology / Vascular DiseasesTo increase blood pressure in adults with septic or other distributive shock21/12/2017
Fasenra Benralizumab Astrazeneca / Medimmune$500 BiologicalRespiratory For add-on maintenance treatment of patients with severe asthma aged 12 years and older, and with an eosinophilic phenotype 14/11/2017 
TymlosAbaloparatideRadius Health Inc$450 ChemicalMusculoskeletal / Obstetrics / Gynecology (Women’s Health)To treat osteoporosis in postmenopausal women28/04/2017
RydaptMidostaurinNovartis Pharms Corp$436 ChemicalOncology / HematologyTo treat acute myeloid leukemia and mastocytosis28/04/2017
XadagoSafinamide Mesylate Newron Pharmaceutical / Zambon S.P.A / US Worldmeds LLC$423 ChemicalNeurologyTo treat Parkinson’s disease21/03/2017
BaxdelaDelafloxacin MeglumineMelinta Therapeutics$400 ChemicalDermatology / Infections and Infectious DiseasesTo treat patients with acute bacterial skin infections19/06/2017
RhopressaNetarsudil DimesylateAerie Pharmaceuticals Inc$350 ChemicalOphthalmologyTo treat glaucoma or ocular hypertension18/12/2017
TrulancePlecanatideSynergy Pharmaceuticals$348 ChemicalGastroenterology / Family MedicineTo treat Chronic Idiopathic Constipation (CIC) in adult patients19/01/2017
BesponsaInotuzumab OzogamicinPfizer $347 BiologicalOncology / HematologyTo treat adults with relapsed or refractory acute lymphoblastic leukemia17/08/2017
RadicavaEdaravoneMitsubishi Tanabe$300 ChemicalNeurologyTo treat patients with amyotrophic lateral sclerosis (ALS)05/05/2017
SymproicNaldemedineShionogi / Purdue Pharma $219 ChemicalGastroenterologyFor the treatment of opioid-induced constipation23/03/2017
PrevymisLetermovirMerck & Co. Inc$200 ChemicalInfections and Infectious DiseasesTo prevent infection after bone marrow transplant08/11/2017
SiliqBrodalumabValeant Pharmaceuticals International Inc$150 BiologicalDermatologyTo treat adults with moderate-to-severe plaque psoriasis15/02/2017
SolosecSecnidazoleSymbiomix Therapeutics$100 ChemicalObstetrics / Gynecology (Women’s Health) / Infections and Infectious DiseasesTo treat bacterial vaginosis15/09/2017
EmflazaDeflazacortMarathon Pharmaceuticals LLC$100 ChemicalPediatrics / Neonatology & MusculoskeletalTo treat patients age 5 years and older with Duchenne muscular dystrophy (DMD)09/02/2017
BenznidazoleBenznidazoleChemo Group / Insud Pharma$75 ChemicalInfections and Infectious DiseasesTo treat children ages 2 to 12 years old with Chagas disease29/08/2017
MepseviiVestronidase Alfa-VjbkUltragenyx Pharm Inc$70 BiologicalGenetic DiseaseTo treat pediatric and adult patients with an inherited metabolic condition called mucopolysaccharidosis type VII (MPS VII), also known as Sly syndrome.15/11/2017
MacrilenMacimorelin AcetateAeterna Zentaris Inc$45 ChemicalEndocrinologyFor the diagnosis of adult growth hormone deficiency20/12/2017
XepiOzenoxacinFerrer International / Medimetriks Pharmaceuticals Inc$10 ChemicalDermatology / Infections and Infectious DiseasesTo treat impetigo11/12/2017