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    Technical details about Protokylol, learn more about the structure, uses, toxicity, action, side effects and more

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    Protokylol

    DOSSIERs // Finished Dosage Forms

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    2D Structure
    1. Also known as: Palison, 136-69-6, Protokylol hcl, Caytine hydrochloride, Nsc-113490, 7u7o8q48io
    Molecular Formula
    C18H22ClNO5
    Molecular Weight
    367.8  g/mol
    InChI Key
    LOVXREQUMZKFCM-UHFFFAOYSA-N
    FDA UNII
    7U7O8Q48IO
    Protokylol Hydrochloride is the hydrochloride salt form of protokylol, a derivative of the beta-adrenergic receptor agonist isoproterenol with bronchodilator activity. Protokylol binds to beta-2 adrenergic receptors in bronchial smooth muscle, thereby activating intracellular adenyl cyclase, an enzyme that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic-3',5'-adenosine monophosphate (cAMP). Increased cAMP levels cause relaxation of bronchial smooth muscle, relieve bronchospasms, improve mucociliary clearance and inhibit the release of mediators of immediate hypersensitivity from cells, especially from mast cells.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    4-[2-[1-(1,3-benzodioxol-5-yl)propan-2-ylamino]-1-hydroxyethyl]benzene-1,2-diol;hydrochloride
    2.1.2 InChI
    InChI=1S/C18H21NO5.ClH/c1-11(6-12-2-5-17-18(7-12)24-10-23-17)19-9-16(22)13-3-4-14(20)15(21)8-13;/h2-5,7-8,11,16,19-22H,6,9-10H2,1H3;1H
    2.1.3 InChI Key
    LOVXREQUMZKFCM-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CC(CC1=CC2=C(C=C1)OCO2)NCC(C3=CC(=C(C=C3)O)O)O.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    7U7O8Q48IO
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Alpha-(alpha-methyl-3,4-methylenedioxyphenethylamino)methyl Protocatechuyl Alcohol

    2. Caytine

    3. Protokylol

    2.3.2 Depositor-Supplied Synonyms

    1. Palison

    2. 136-69-6

    3. Protokylol Hcl

    4. Caytine Hydrochloride

    5. Nsc-113490

    6. 7u7o8q48io

    7. Caytine Hydrochloride; Nsc 113490

    8. Asmetil

    9. Biturix

    10. Beres

    11. Atma-sanol

    12. 4-[2-[1-(1,3-benzodioxol-5-yl)propan-2-ylamino]-1-hydroxyethyl]benzene-1,2-diol;hydrochloride

    13. Einecs 205-254-8

    14. Nsc 113490

    15. Unii-7u7o8q48io

    16. Protokylolhydrochlorid

    17. Protoklol Hydrochloride

    18. 4-(2-{[2-(1,3-benzodioxol-5-yl)-1-methylethyl]amino}-1-hydroxyethyl)-1,2-benzenediol Hydrochloride

    19. 1,2-benzenediol, 4-(2-((2-(1,3-benzodioxol-5-yl)-1-methylethyl)amino)-1-hydroxyethyl)-, Hcl

    20. 4-(2-((2-(1,3-benzodioxol-5-yl)-1-methylethyl)amino)-1-hydroxyethyl)-1,2-benzenediol Hcl

    21. 1,2-benzenediol, 4-(2-((2-(1,3-benzodioxol-5-yl)-1-methylethyl)amino)-1-hydroxyethyl)-, Hydrochloride

    22. Schembl210099

    23. Chembl1200893

    24. Dtxsid30929210

    25. Nsc113490

    26. Protokylol Hydrochloride [mi]

    27. Protokylol Hydrochloride [mart.]

    28. Protokylol Hydrochloride [who-dd]

    29. Alpha-(((alpha-methyl-3,4-methylenedioxyphenethyl)amino)methyl)protocatechuyl Alcohol, Hydrochloride

    30. Benzyl Alcohol, 3,4-dihydroxy-alpha-(((alpha-methyl-3,4-(methylenedioxy)phenethyl)amino)methyl)-, Hydrochloride

    31. Ft-0674124

    32. Protokylol Hydrochloride [green Book]

    33. Protokylol Hydrochloride [orange Book]

    34. Q27268861

    35. Wln: T56 Bo Do Chj G1y1 & M1yqr Cq Dq & Gh

    36. 1, 4-[2-[[2-(1,3-benzodioxol-5-yl)-1-methylethyl]amino]-1-hydroxyethyl]-, Hydrochloride

    37. .alpha.-(((.alpha.-methyl-3,4-methylenedioxyphenethyl)amino)methyl)protocatechuyl Alcohol, Hydrochloride

    38. 4-(2-{[1-(2h-1,3-benzodioxol-5-yl)propan-2-yl]amino}-1-hydroxyethyl)benzene-1,2-diol--hydrogen Chloride (1/1)

    39. Benzyl Alcohol,4-dihydroxy-.alpha.-[[[.alpha.-methyl-3,4-(methylenedioxy)phenethyl]amino]methyl]-, Hydrochloride

    2.4 Create Date
    2005-08-08
    3 Chemical and Physical Properties
    Molecular Weight 367.8 g/mol
    Molecular Formula C18H22ClNO5
    Hydrogen Bond Donor Count5
    Hydrogen Bond Acceptor Count6
    Rotatable Bond Count6
    Exact Mass367.1186505 g/mol
    Monoisotopic Mass367.1186505 g/mol
    Topological Polar Surface Area91.2 Ų
    Heavy Atom Count25
    Formal Charge0
    Complexity396
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count2
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
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