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    Technical details about Pritelivir, learn more about the structure, uses, toxicity, action, side effects and more

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    Pritelivir

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    2D Structure
    1. Also known as: 348086-71-5, Bay 57-1293, Bay-57-1293, Aic316, Pritelivir [inn], N-methyl-n-(4-methyl-5-sulfamoylthiazol-2-yl)-2-(4-(pyridin-2-yl)phenyl)acetamide
    Molecular Formula
    C18H18N4O3S2
    Molecular Weight
    402.5  g/mol
    InChI Key
    IVZKZONQVYTCKC-UHFFFAOYSA-N
    FDA UNII
    07HQ1TJ4JE
    Pritelivir is a thiazolylamide and helicase-primase enzyme inhibitor that is active against herpes simplex virus types 1 and 2 (HSV-1 and HSV-2). Pritelivir inhibits the helicase-primase complex and prevents helicase or primase catalytic cycling of viral DNA, which interferes with DNA replication and growth. This agent does not require activation by HSV thymidine kinase and has a longer plasma half-life than nucleoside analogues.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    N-methyl-N-(4-methyl-5-sulfamoyl-1,3-thiazol-2-yl)-2-(4-pyridin-2-ylphenyl)acetamide
    2.1.2 InChI
    InChI=1S/C18H18N4O3S2/c1-12-17(27(19,24)25)26-18(21-12)22(2)16(23)11-13-6-8-14(9-7-13)15-5-3-4-10-20-15/h3-10H,11H2,1-2H3,(H2,19,24,25)
    2.1.3 InChI Key
    IVZKZONQVYTCKC-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CC1=C(SC(=N1)N(C)C(=O)CC2=CC=C(C=C2)C3=CC=CC=N3)S(=O)(=O)N
    2.2 Other Identifiers
    2.2.1 UNII
    07HQ1TJ4JE
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Aic316

    2. Bay 57-1293

    3. N-(5-(aminiosulfonyl)-4-methyl-1,3-thiazol-2-yl)-n-methyl-2-(4-(2-pyridinyl)phenyl)acetamide

    2.3.2 Depositor-Supplied Synonyms

    1. 348086-71-5

    2. Bay 57-1293

    3. Bay-57-1293

    4. Aic316

    5. Pritelivir [inn]

    6. N-methyl-n-(4-methyl-5-sulfamoylthiazol-2-yl)-2-(4-(pyridin-2-yl)phenyl)acetamide

    7. Bay57-1293

    8. Aic-316

    9. N-methyl-n-(4-methyl-5-sulfamoyl-1,3-thiazol-2-yl)-2-(4-pyridin-2-ylphenyl)acetamide

    10. 07hq1tj4je

    11. Pritelivir (bay 57-1293)

    12. 348086-71-5 (free Base)

    13. Bay 57-1293;aic316

    14. Unii-07hq1tj4je

    15. Benzeneacetamide, N-(5-(aminosulfonyl)-4-methyl-2-thiazolyl)-n-methyl-4-(2-pyridinyl)-

    16. N-(5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl)-n-methyl-2-(4-(2-pyridinyl)phenyl)acetamide

    17. N-[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-n-methyl-2-[4-(2-pyridinyl)phenyl]acetamide

    18. N-methyl-n-(4-methyl-5-sulfamoyl-1,3-thiazol-2-yl)-2-(4-(pyridin-2-yl)phenyl)acetamide

    19. N-methyl-n-(4-methyl-5-sulfamoyl-1,3-thiazol-2-yl)-2-[4-(pyridin-2-yl)phenyl]acetamide

    20. Pritelivir;aic316

    21. Pritelivir [who-dd]

    22. Pritelivirbay-57-1293

    23. Schembl1074614

    24. Pritelivir(bay 57-1293)

    25. Chembl4069597

    26. Aic 316

    27. Dtxsid70188344

    28. Ex-a247

    29. Hms3653b15

    30. Hms3744e03

    31. Bcp08742

    32. Yna08671

    33. Zinc3955689

    34. Mfcd18633192

    35. S7546

    36. Akos026750515

    37. Ccg-268675

    38. Cs-1693

    39. Db11844

    40. Ks-5353

    41. Sb19731

    42. Ncgc00378984-02

    43. Ac-33065

    44. Da-42669

    45. Hy-15303

    46. Ls-14637

    47. N-(5-(aminiosulfonyl)-4-methyl-1,3-thiazol-2-yl)-n-methyl-2-(4-(2-pyridinyl)phenyl)acetamide

    48. Ft-0732285

    49. Sw219861-1

    50. A13324

    51. A857450

    52. Q15410303

    53. N-methyl-n-(4-methyl-5-sulfamoyl-thiazol-2-yl)-2-[4-(2-pyridyl)phenyl]acetamide

    54. Bay-571293; Aic-316; Aic 316;n-[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-n-methyl-2-[4-(2-pyridinyl)phenyl]acetamide;n-methyl-n-(4-methyl-5-sulfamoylthiazol-2-yl)-2-(4-(pyridin-2-yl)phenyl)acetamide

    55. N-[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-n-methyl-2-[4-(2-pyridinyl)phenyl] Acetamide

    56. N-[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-n-methyl-2-[4-(2-pyridyl)phenyl]acetamide

    57. N-[5-(aminosulphonyl)-4-methyl-1,3-thiazol-2-yl]-n-methyl-2-[4-(2-pyridinyl)phenyl]acetamide

    2.4 Create Date
    2005-08-01
    3 Chemical and Physical Properties
    Molecular Weight 402.5 g/mol
    Molecular Formula C18H18N4O3S2
    XLogP32.1
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count7
    Rotatable Bond Count5
    Exact Mass402.08203280 g/mol
    Monoisotopic Mass402.08203280 g/mol
    Topological Polar Surface Area143 Ų
    Heavy Atom Count27
    Formal Charge0
    Complexity617
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Enzyme Inhibitors

    Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. (See all compounds classified as Enzyme Inhibitors.)

    Antiviral Agents

    Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly. (See all compounds classified as Antiviral Agents.)

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