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    Paliroden

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    2D Structure
    Also known as: 188396-77-2, Paliroden [inn], Sr57667b, Palirodene, Palirodeno, Unii-17vj76l90t
    Molecular Formula
    C26H24F3N
    Molecular Weight
    407.5  g/mol
    InChI Key
    CNEWKIDCGDXBDE-UHFFFAOYSA-N
    FDA UNII
    17VJ76L90T
    Paliroden is an orally active neurotrophic, non-peptidic compound that activates synthesis of endogenous neurotrophines. Studies show that use of paliroden increased the rate of formation of both neural progenitors and mature neurons. It is indicated for use in Alzheimer's Disease and Parkinsons.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    1-[2-(4-phenylphenyl)ethyl]-4-[3-(trifluoromethyl)phenyl]-3,6-dihydro-2H-pyridine
    2.1.2 InChI
    InChI=1S/C26H24F3N/c27-26(28,29)25-8-4-7-24(19-25)23-14-17-30(18-15-23)16-13-20-9-11-22(12-10-20)21-5-2-1-3-6-21/h1-12,14,19H,13,15-18H2
    2.1.3 InChI Key
    CNEWKIDCGDXBDE-UHFFFAOYSA-N
    2.2 Other Identifiers
    2.2.1 UNII
    17VJ76L90T
    2.3 Synonyms
    2.3.1 Depositor-Supplied Synonyms

    1. 188396-77-2

    2. Paliroden [inn]

    3. Sr57667b

    4. Palirodene

    5. Palirodeno

    6. Unii-17vj76l90t

    7. 17vj76l90t

    8. Sr5-7667b

    9. 1-(2-(biphenyl-4-yl)ethyl)-4-(3-(trifluoromethyl)phenyl)-1,2,3,6-tetrahydropyridine

    10. 1-(2-([1,1'-biphenyl]-4-yl)ethyl)-4-(3-(trifluoromethyl)phenyl)-1,2,3,6-tetrahydropyridine

    11. Palirodenum

    12. 1-(2-((1,1'-biphenyl)-4-yl)ethyl)-4-(3-(trifluoromethyl)phenyl)-1,2,3,6-tetrahydropyridine

    13. 1-(2-{[1,1'-biphenyl]-4-yl}ethyl)-4-[3-(trifluoromethyl)phenyl]-1,2,3,6-tetrahydropyridine

    14. 1-[2-([1,1'-biphenyl]-4-yl)ethyl]-4-[3-(trifluoromethyl)phenyl]-1,2,3,6-tetrahydropyridine

    15. Refchem:169612

    16. Sr57667 Base

    17. 1-[2-(4-phenylphenyl)ethyl]-4-[3-(trifluoromethyl)phenyl]-3,6-dihydro-2h-pyridine

    18. Orb1706848

    19. Schembl4587135

    20. Chembl2107767

    21. Schembl29375649

    22. C26h24f3n

    23. Dtxsid60870180

    24. Cnewkidcgdxbde-uhfffaoysa-n

    25. Nha39677

    26. Ex-a12275

    27. Mfcd30747895

    28. Akos040742362

    29. Cs-6710

    30. Db05454

    31. Da-56559

    32. Ms-26996

    33. Hy-101580

    34. Ns00072159

    35. Q27251945

    2.4 Create Date
    2006-10-26
    3 Chemical and Physical Properties
    Molecular Weight 407.5 g/mol
    Molecular Formula C26H24F3N
    XLogP36.6
    Hydrogen Bond Donor Count0
    Hydrogen Bond Acceptor Count4
    Rotatable Bond Count5
    Exact Mass Da
    Monoisotopic Mass Da
    Topological Polar Surface Area3.2
    Heavy Atom Count30
    Formal Charge0
    Complexity555
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Indication

    Investigated for use/treatment in Alzheimer's disease and Parkinson's disease.

    5 Pharmacology and Biochemistry
    5.1 Mechanism of Action

    SR 57667 may be an irreversible MAOB inhibitor.

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