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2D Structure
Also known as: 2-(diethylamino)ethanol, Diethylaminoethanol, 100-37-8, N,n-diethylethanolamine, Diethylethanolamine, Deae
Molecular Formula
C6H15NO
Molecular Weight
117.19  g/mol
InChI Key
BFSVOASYOCHEOV-UHFFFAOYSA-N
FDA UNII
S6DL4M053U

1 2D Structure

2D Structure

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
2-(diethylamino)ethanol
2.1.2 InChI
InChI=1S/C6H15NO/c1-3-7(4-2)5-6-8/h8H,3-6H2,1-2H3
2.1.3 InChI Key
BFSVOASYOCHEOV-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CCN(CC)CCO
2.2 Other Identifiers
2.2.1 UNII
S6DL4M053U
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 2-(diethylamino)ethanol

2. 2-(dimethylamino)ethanol Hydrochloride

3. 2-(n,n-dimethylamino)ethanol Hydrochloride

4. 2-diethylaminoethanol Hydrochloride

5. 2-diethylaminoethanol Hydrochloride, 14c-labeled

6. 2-diethylaminoethanol Sulfate (2:1)

7. 2-diethylaminoethanol Tartrate

8. 2-diethylaminoethanol, Sodium Salt

9. Deae

10. Deanol Hydrochloride

11. Diethylaminoethanol

12. Diethylethanolamine

13. Ethanol, 2-(dimethylamino)-, Hydrochloride (1:1)

14. Ethanol, 2-dimethylamino-, Hydrochloride

15. N,n-diethylethanolamine

2.3.2 Depositor-Supplied Synonyms

1. 2-(diethylamino)ethanol

2. Diethylaminoethanol

3. 100-37-8

4. N,n-diethylethanolamine

5. Diethylethanolamine

6. Deae

7. (diethylamino)ethanol

8. Ethanol, 2-(diethylamino)-

9. N,n-diethyl-2-aminoethanol

10. (2-hydroxyethyl)diethylamine

11. Diethyl(2-hydroxyethyl)amine

12. Diethylmonoethanolamine

13. 2-hydroxytriethylamine

14. Pennad 150

15. Diaethylaminoaethanol

16. 2-(diethylamino)ethan-1-ol

17. 2-(n,n-diethylamino)ethanol

18. N,n-diethylmonoethanolamine

19. N,n-diethyl-2-hydroxyethylamine

20. Beta-diethylaminoethanol

21. Beta-hydroxytriethylamine

22. 2-(diethylamino)ethyl Alcohol

23. Diethylamino Ethanol

24. N-diethylaminoethanol

25. 2-diethylamino-ethanol

26. 2-n-diethylaminoethanol

27. Diethyl Ethanolamine

28. Deea

29. Beta-diethylaminoethyl Alcohol

30. N-(diethylamino)ethanol

31. N,n-diethyl-n-(beta-hydroxyethyl)amine

32. Nsc 8759

33. N,n-diethylaminoethanol

34. 2-(diethylamino)-ethanol

35. 2-n-(diethylamino)ethanol

36. .beta.-(diethylamino)ethanol

37. Ethanol,2-diethylamino

38. S6dl4m053u

39. Beta-(diethylamino)ethyl Alcohol

40. Chebi:52153

41. .beta.-(diethylamino)ethyl Alcohol

42. Nsc-8759

43. N,n-diethyl-n-(.beta.-hydroxyethyl)amine

44. Dsstox_cid_1837

45. Dsstox_rid_76358

46. Dsstox_gsid_21837

47. Cas-100-37-8

48. Diaethylaminoaethanol [german]

49. Ccris 4793

50. Hsdb 329

51. Einecs 202-845-2

52. Un2686

53. Unii-s6dl4m053u

54. Ai3-16309

55. 2-diethylamino

56. Diathylaminoathanol

57. Diethylamlnoethanol

58. Mfcd00002850

59. N,n-diethyl Ethanolamine

60. N, N-diethylethanolamine

61. Beta-(diethylamino)ethanol

62. N,n-diethyl Ethanol Amine

63. 2-diethylaminoethanol [un2686] [corrosive]

64. .beta.-hydroxytriethylamine

65. Ec 202-845-2

66. Schembl3114

67. 2-diethylaminoethanol, 9ci

68. Chembl1183

69. Diaethylaminoaethanol(german)

70. 2-(diethylamino)-1-ethanol

71. Mls002174251

72. 2-(n,n-diethylamino)-ethanol

73. 2-(diethylamino)ethanol, 99%

74. Dtxsid5021837

75. Diethylaminoethanol [hsdb]

76. N-(beta-hydroxyethyl)diethylamine

77. Nsc8759

78. Hms3039i08

79. Zinc388479

80. 2-(diethylamino)ethanol, >=99%

81. Diethyl Ethanolamine [inci]

82. Diethylaminoethanol [mart.]

83. Wln: Q2n2 & 2

84. Adal1185323

85. Diethylaminoethanol [who-dd]

86. N-(hydroxyethyl)-n,n-diethyl Amine

87. Tox21_201463

88. Tox21_300037

89. Bbl012211

90. Stl163552

91. 2-(diethylamino)ethanol [mi]

92. 2-(diethylamino)ethanol, >=99.5%

93. Akos000119883

94. Un 2686

95. Ncgc00090925-01

96. Ncgc00090925-02

97. Ncgc00090925-03

98. Ncgc00253920-01

99. Ncgc00259014-01

100. A 22

101. Bp-20552

102. Smr001261425

103. Vs-03234

104. Db-012722

105. D0465

106. 2-diethylaminoethanol [un2686] [corrosive]

107. D88192

108. 2-(diethylamino)ethanol, Purum, >=99.0% (gc)

109. Q209373

110. 2-diethylaminoethanol 100 Microg/ml In Acetonitrile

111. J-520312

112. Diethyl Ethanolamine Diethylaminoethanol 2-hydroxytriethylamine

2.4 Create Date
2005-03-26
3 Chemical and Physical Properties
Molecular Weight 117.19 g/mol
Molecular Formula C6H15NO
XLogP30.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count4
Exact Mass117.115364102 g/mol
Monoisotopic Mass117.115364102 g/mol
Topological Polar Surface Area23.5 Ų
Heavy Atom Count8
Formal Charge0
Complexity43.8
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Anti-Inflammatory Agents, Non-Steroidal

Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)


4.2 Absorption, Distribution and Excretion

ORALLY ADMIN TO RATS, WAS MAINLY EXCRETED VIA KIDNEYS. ELIMINATED WITHIN FIRST 24 HR. AFTER 48 HR EXCRETED INDEPENDENTLY OF DOSE. AFTER 40 DAYS STILL BEING ELIMINATED. UP TO 60% ACCUMULATED IN LIVER. CNS & SPINAL CORD SHOWED HIGHEST CONCN AFTER 7 DAYS.

SCHULTE KE ET AL; ARZNEIM- FORSCH 22 (8): 1381 (1972)


The absorption of 2-diethylaminoethanol (administered orally as 2-diethylaminoethanol acid malate or 'Cerebrol') in healthy adult rats is very rapid, reaching a peak plasma level in 30 min. The biological half-life is 3.5 hr with 39% of the excreted product appearing in the urine after 48 hr.

Snyder, R. (ed.). Ethel Browning's Toxicity and Metabolism of Industrial Solvents. 2nd ed. Volume II: Nitrogen and Phosphorus Solvents. Amsterdam-New York-Oxford: Elsevier, 1990., p. 412


4.3 Metabolism/Metabolites

CHRONIC ORAL ADMIN ... TO RATS RESULTS IN LIVER ACCUM OF UP TO 60% OF THE DRUG. ... METABOLITES PRODUCED WERE DIETHYLAMINOETHANOL N-OXIDE, DIETHYLAMINOACETIC ACID & ETHYLAMINOETHANOL ... .

The Chemical Society. Foreign Compound Metabolism in Mammals Volume 3. London: The Chemical Society, 1975., p. 272


4.4 Biological Half-Life

The biological half-life is 3.5 hr ... .

Snyder, R. (ed.). Ethel Browning's Toxicity and Metabolism of Industrial Solvents. 2nd ed. Volume II: Nitrogen and Phosphorus Solvents. Amsterdam-New York-Oxford: Elsevier, 1990., p. 413