Please Wait
Applying Filters...
menu
    • menu
    Pfanstiehl, a global leader in the manufacture of cGMP high purity, low endotoxin, low metals (HPLE-LM)TM injectable grade excipients.

    Virtual Booth

    Contact Supplier

    Global Pharma Healthcare: Setting the global benchmark in quality, innovation, and care

    Virtual Booth

    Contact Supplier

    Transo-Pharm GmbH works globally to supply Active Pharmaceutical Ingredients adhering to the highest quality & GMP standards.

    Virtual Booth

    Contact Supplier

    Phyton is a World Leader in Plant Cell Fermentation Technology and Commercial Manufacturing.

    Virtual Booth

    Contact Supplier

    Farmak works in the development, production and marketing of APIs, Intermediates & Specialties// FDA inspected.

    Virtual Booth

    Contact Supplier

    pharmacompass-2-m-2025-11-03

    Virtual Booth

    An Enquiry

    Menu

    Leucovorin Calcium

    ACTIVE PHARMA INGREDIENTS

    DEVELOPMENTS

    FINISHED DOSAGE FORMULATIONS

    GLOBAL SALES INFORMATION

    MARKET PLACE

    PharmaCompass
    $ API Ref.Price (USD/KG) : 2,262Xls

    Filters

    clear-filterReset all filters
    2D Structure
    Also known as: Calcium leucovorin, Folidan, Rescuvolin, Calcii folinas, Leucovorin calcium preservative free, Lederfolat
    Molecular Formula
    C20H21CaN7O7
    Molecular Weight
    511.5  g/mol
    InChI Key
    KVUAALJSMIVURS-ZEDZUCNESA-L
    FDA UNII
    RPR1R4C0P4
    The active metabolite of Folic acid, Pteroyl-D-glutamic acid is used principally as its calcium salt as an antidote to folic acid antagonists which block the conversion of folic acid to folinic acid. Folic acid, a water-soluble B-complex vitamin, is found in foods such as liver, kidneys, yeast, and leafy, green vegetables. Folic acid is used to diagnose folate deficiency and to treat topical sprue and megaloblastic and macrocytic anemias, hematologic complications resulting from a deficiency in folic acid. A member of the vitamin B family that stimulates the hematopoietic system. It is present in the liver and kidney and is found in mushrooms, spinach, yeast, green leaves, and grasses (poaceae). Folic acid is used in the treatment and prevention of folate deficiencies and megaloblastic anemia.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    calcium (2S)-2-[[4-[(2-amino-5-formyl-4-oxo-3,6,7,8-tetrahydropteridin-6-yl)methylamino]benzoyl]amino]pentanedioate
    2.1.2 InChI
    InChI=1S/C20H23N7O7.Ca/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30;/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32);/q;+2/p-2/t12?,13-;/m0./s1
    2.1.3 InChI Key
    KVUAALJSMIVURS-ZEDZUCNESA-L
    2.2 Other Identifiers
    2.2.1 UNII
    RPR1R4C0P4
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Citrovorum Factor

    2. Calcium Folinate

    3. Calcium Leucovorin

    2.3.2 Depositor-Supplied Synonyms

    1. Calcium Leucovorin

    2. Folidan

    3. Rescuvolin

    4. Calcii Folinas

    5. Leucovorin Calcium Preservative Free

    6. Lederfolat

    7. Folinate Calcium

    8. Anhydrous Calcium Folinate

    9. Rpr1r4c0p4

    10. Folaren

    11. Nsc-3590

    12. Leucovorin Calcium [usp]

    13. Calcium N-(p-((((6rs)-2-amino-5-formyl-5,6,7,8-tetrahydro-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-l-glutamate (1:1)

    14. Lederfolin

    15. Rescufolin

    16. Folacal

    17. Foliben

    18. Leucosar

    19. Tonofolin

    20. Calc Folinate

    21. Leucovorin Calcium (usp)

    22. Citrovorum Factor

    23. Nsc3590

    24. Calcifolin

    25. Adinepar

    26. Calfolex

    27. Calinat

    28. Cehafolin

    29. Citofolin

    30. Dalisol

    31. Disintox

    32. Divical

    33. Folaxin

    34. Folidar

    35. Folinac

    36. Folinoral

    37. Folinvit

    38. Foliplus

    39. Citrec

    40. Ecofol

    41. Emovis

    42. Folix

    43. Uzel

    44. Flynoken A

    45. Foli-cell

    46. Factor, Citrovorum

    47. Cromatonbic Folinico

    48. Refchem:55463

    49. 5-formyl Tetrahydrofolate

    50. 216-082-8

    51. 846-741-0

    52. N-(4-(((2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl)amnio)benzoyl)-l-glutamic Acid, Calcium Salt (1:1)

    53. N-(p-(((2-amino-5-formyl-5,6,7,8-tetrahydro-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)glutamic Acid

    54. Folinic Acid Calcium Salt Pentahydrate

    55. Folinic Acid Calcium Salt

    56. Wellcovorin

    57. Folinate-sf Calcium

    58. Calcium Citrovorum Factor

    59. Calcium Folinate [inn]

    60. Folinic Acid-sf, Calcium Salt

    61. Folinic Acid (calcium)

    62. (+)-l-folinic Acid, Calcium Salt

    63. Calciumfolinate

    64. Leucovorin Calcium Salt

    65. L-glutamic Acid, N-[4-[[(2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-, Calcium Salt (1:1)

    66. Lederfoline

    67. 80433-71-2

    68. Calcium (4-(((2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl)methyl)amino)benzoyl)-l-glutamate

    69. L-glutamic Acid, N-(4-(((2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-, Calcium Salt (1:1)

    70. Calcium L-folinate

    71. Calcii Folinas [inn-latin]

    72. Calcium;(2s)-2-[[4-[(2-amino-5-formyl-4-oxo-3,6,7,8-tetrahydropteridin-6-yl)methylamino]benzoyl]amino]pentanedioate

    73. Folinic Acid Calcium Salt Hydrate

    74. Calcium 5-formyltetrahydrofolate

    75. Folinato Calcico [inn-spanish]

    76. Folinate De Calcium [inn-french]

    77. Nsc 3590

    78. Einecs 216-082-8

    79. Unii-rpr1r4c0p4

    80. 5-formyl-5,6,7,8-tetrahydrofolic Acid Calcium Salt Hydrate

    81. Prestwick_224

    82. Calcium Folinate Rs

    83. Calcium Folinate Crs

    84. Schembl18573

    85. Spectrum1500364

    86. Calcium Folinate [jan]

    87. Orb1310893

    88. Calcium Folinate [vandf]

    89. Chembl1201138

    90. Schembl29360881

    91. Chebi:31340

    92. Hms500l04

    93. Calcium Folinate [mart.]

    94. Dtxsid20872448

    95. Calcium Folinate [who-dd]

    96. Folfox Component Leucovorin Calcium

    97. Glxc-06576

    98. Hms1570c18

    99. Hms1920j05

    100. Hms2091p21

    101. Hms2097c18

    102. Hms3714c18

    103. Leucovorin Calcium [vandf]

    104. Folinic Acid (calcium) (standard)

    105. Leucovorin Calcium [usp-rs]

    106. Ccg-38930

    107. Ebc-15053

    108. Hy-13664r

    109. Akos015894859

    110. Akos032949578

    111. Calcium Folinate [ep Impurity]

    112. Ac-7456

    113. Ccg-269782

    114. Cs-1363

    115. Fc61510

    116. Leucovorin Calcium [orange Book]

    117. Calcium Folinate (leucovorin Calcium) Rs

    118. As-13746

    119. Folinate Calcium 100 Microg/ml In Water

    120. Glutamic Acid, N-(p-(((2-amino-5-formyl-5,6,7,8-tetrahydro-3-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-, Calcium Salt (1:1), L-

    121. Hy-13664

    122. Leucovorin Calcium [usp Monograph]

    123. Folinic Acid (as Calcium Folinate)

    124. C2235

    125. Ns00127423

    126. En300-6735051

    127. 5-formyl-5,6,7,8-tetrahydrofolic Acid Calcium Salt

    128. Q27077063

    129. Z2683233771

    130. Calcium (2s)-2-[(4-{[(2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl)methyl]amino}phenyl)formamido]pentanedioate

    2.4 Create Date
    2019-01-15
    3 Chemical and Physical Properties
    Molecular Weight 511.5 g/mol
    Molecular Formula C20H21CaN7O7
    Hydrogen Bond Donor Count5
    Hydrogen Bond Acceptor Count10
    Rotatable Bond Count7
    Exact Mass Da
    Monoisotopic Mass Da
    Topological Polar Surface Area221
    Heavy Atom Count35
    Formal Charge0
    Complexity900
    Isotope Atom Count0
    Defined Atom Stereocenter Count1
    Undefined Atom Stereocenter Count1
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Antidotes

    Agents counteracting or neutralizing the action of POISONS.

    Vitamin B Complex

    A group of water-soluble vitamins, some of which are COENZYMES.

    4.2 FDA Pharmacological Classification
    4.2.1 Pharmacological Classes
    Folic Acid [CS]; Folate Analog [EPC]
    4.3 ATC Code

    A12AA20

    S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (2021) DOI:10.1021/acsenvironau.1c00008. List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355

    4.4 Metabolism/Metabolites

    Hepatic and intestinal mucosal, the main metabolite being the active 5-methyltetrahydrofolate. Leucovorin is readily converted to another reduced folate, 5,10-methylenetetrahydrofolate, which acts to stabilize the binding of fluorodeoxyridylic acid to thymidylate synthase and thereby enhances the inhibition of this enzyme. Half Life: 6.2 hours

    • Privacy policy
    • Terms and conditions
    • Disclaimers
    • LinkedIn
    • Product listings are provided for informational purposes only. We do not supply or sell any products. Any products that may be covered by patent(s) are supplied solely for uses permitted under Section 107A of the Indian Patents Act and not for commercial sale.